Publications by authors named "Yuri Kasagi"
Article Synopsis
- Pseudohypoaldosteronism type II (PHAII) is a hereditary condition linked to mutations in genes like CUL3, leading to the decreased degradation of WNK proteins, which contributes to hypertension.
- A study using mice with a specific CUL3 mutation revealed a PHAII-like phenotype and significantly reduced levels of KLHL3, a protein crucial for linking WNKs to CUL3, while other KLHL family proteins remained unchanged.
- The findings suggest that the reduction of KLHL3 specifically results from the CUL3 mutation, enhancing our understanding of the disease's underlying mechanisms.
Article Synopsis
- The Keap1-Nrf2-ARE signaling pathway is crucial for protecting cells from oxidative stress by regulating the expression of cytoprotective enzymes.
- Researchers aimed to disrupt the interaction between Keap1 and Nrf2 to elevate Nrf2 expression and enhance the antioxidant response.
- By screening 1,633 drugs through a new fluorescence correlation spectroscopy system, they identified 12 candidates, with 2 notably increasing Nrf2 levels and upregulating related gene activity in liver cells.
Muscle wasting or sarcopenia contributes to morbidity and mortality in patients with cancer, renal failure, or heart failure, and in elderly individuals. Na-K-2Cl cotransporter 1 (NKCC1) is highly expressed in mammalian skeletal muscle, where it contributes to the generation of membrane ion currents and potential. However, the physiologic function of NKCC1 in myogenesis is unclear.
View Article and Find Full Text PDFImpaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice.
Biochem Biophys Res Commun
May 2017
Mutations in the with-no-lysine kinase 1 (WNK1), WNK4, Kelch-like 3 (KLHL3), and Cullin3 (CUL3) genes were identified as being responsible for hereditary hypertensive disease pseudohypoaldosteronism type II (PHAII). Normally, the KLHL3/CUL3 ubiquitin ligase complex degrades WNKs. In PHAII, the loss of interaction between KLHL3 and WNK4 increases levels of WNKs because of impaired ubiquitination, leading to abnormal over-activation of the WNK-OSR1/SPAK-NCC cascade in the kidney's distal convoluted tubules (DCT).
View Article and Find Full Text PDFBackground: Renal anemia of chronic kidney disease (CKD) is generally treated by erythropoiesis-stimulating agents (ESAs). However, there are individual differences in patients' responsiveness to ESA, which may affect the prognosis of CKD.
Methods: The effect of ESAs on hemoglobin was followed in 297 CKD patients with renal anemia.
A 48-year-old man with autosomal dominant polycystic kidney disease (ADPKD) was admitted to our hospital with a 5-day history of lower right back pain, high-grade fever, and arthralgia. He was diagnosed with right kidney cyst infection and bacteremia due to Helicobacter cinaedi (H. cinaedi) based on these symptoms, highly elevated CRP (32.
View Article and Find Full Text PDFBackground: Hyponatremia is associated with increased mortality in chronic kidney disease with and without end-stage renal disease (ESRD). Increasing evidence suggests that hyponatremia is not only a marker of severe underlying disease, but also a direct contributor to mortality. However, specific pathogenesis or diseases contributing to mortality in the hyponatremic population are unknown.
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