Publications by authors named "Yuri Cho"

Although a robust association between metabolic dysfunction-associated fatty liver disease (MASLD) and cardiovascular disease (CVD) has been established, the impact of MASLD on CVD risk in young adults has not been fully evaluated. This population-based study included adults aged 20-39 years who underwent health screening examinations from 2009 to 2012 based on Korean National Health Insurance Service database. MASLD was defined as a fatty liver index ≥ 30 without any other cause of steatosis, and presence of one or more cardiometabolic risk factors.

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Purpose: New nomenclature has incorporated metabolic traits and/or alcohol intake history to replace nonalcoholic fatty liver disease (NAFLD). Concerning the performance of different terminologies in Asian population, this study aimed to investigate the risk of developing hepatocellular carcinoma (HCC) in persons meeting the criteria for subclasses of fatty liver disease.

Materials And Methods: Between 2002 and 2021, 28,749 participants from the cancer registry linkage, who had no prior history of HCC, were prospectively included.

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Liver fibrosis, a critical predictor of the prognosis of metabolic dysfunction-associated steatotic liver disease (MASLD), is traditionally diagnosed via biopsy. Nevertheless, non-invasive alternatives, such as serum biomarkers, vibration-controlled transient elastography, and magnetic resonance elastography, have become prominent because of the limitations of biopsies. Serum biomarkers, such as fibrosis-4 index and NFS Score, are also used widely, offering reliable diagnostic performance for advanced fibrosis.

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  • The study explored the link between nonalcoholic fatty liver disease (NAFLD) and the risk of developing atrial fibrillation (AF), considering factors such as age and liver fibrosis.
  • Researchers analyzed data from over 3 million participants, categorizing them based on their NAFLD status and identifying new cases of AF over a median follow-up of 9.3 years.
  • The findings indicated that the risk of new-onset AF significantly increased with both the severity of NAFLD and the presence of advanced fibrosis, particularly among younger individuals aged 20-29.
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  • Ischemia-reperfusion injury (IRI) during myocardial infarction lacks effective treatments, but bilirubin's anti-inflammatory and antioxidant properties show potential for therapy.
  • The study used a rat model to assess bilirubin nanoparticles, identifying 3,616 protein groups and observing distinct protein expression changes with and without bilirubin treatment.
  • Significant findings included upregulation of Wnt and insulin signaling pathways and Golgi markers, indicating the need for more research on bilirubin nanoparticles for cardiac protection in humans.
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Exploiting crystallographic data repositories for large-scale quantum chemical computations requires the rapid and accurate extraction of the molecular structure, charge and spin from the crystallographic information file. Here, we develop a general approach to assign the ground state spin of transition metal complexes, in complement to our previous efforts on determining metal oxidation states and bond order within the software. Starting from a database of 31k transition metal complexes extracted from the Cambridge Structural Database with , we construct the TM-GSspin dataset, which contains 2063 mononuclear first row transition metal complexes and their computed ground state spins.

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  • - This study investigated the metabolic effects of different antiviral treatments for chronic hepatitis B (specifically focusing on tenofovir alafenamide [TAF]) using a 15-year cohort of patients in Korea, separated into two groups: those on a single antiviral and those who switched antivirals.
  • - After applying statistical methods, the findings revealed significant changes in cholesterol levels among groups, with TAF causing an increase in total cholesterol and a notable rise in atherosclerotic cardiovascular disease (ASCVD) risk compared to other treatments.
  • - In patients who switched from tenofovir disoproxil fumarate (TDF) to TAF, there was a significant increase in total cholesterol post-switch, highlighting the potential metabolic
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Background/aims: Bariatric intervention has been reported to be an effective way to improve metabolic dysfunction-associated steatotic liver disease (MASLD) in obese individuals. The current systemic review aimed to assess the changes in MRI-determined hepatic proton density fat fraction (MRI-PDFF) and nonalcoholic fatty liver disease activity score (NAS) after bariatric surgery or intragastric balloon/gastric banding in MASLD patients with obesity.

Methods: We searched various databases including PubMed, OVID Medline, EMBASE, and Cochrane Library.

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  • Childhood obesity is linked to a rising prevalence of nonalcoholic fatty liver disease (NAFLD) in kids and teens, yet systematic studies on this issue are scarce.
  • A comprehensive search of multiple databases yielded 62 relevant studies for analysis, revealing that NAFLD affects 13% of the general pediatric population and 47% of obese kids.
  • The study found significant gender differences in prevalence, with higher rates in males than females for both general and obese populations, highlighting the urgent need for more epidemiological research on NAFLD in pediatrics.
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  • A study was conducted to explore the relationship between serum gamma-glutamyl transferase (GGT) levels and mortality rates in patients with type 2 diabetes, utilizing a large Korean health-screening database.
  • Out of nearly 10 million participants observed over an average of 8.1 years, higher GGT levels were linked to increased all-cause mortality and specific causes of death, such as cardiovascular diseases, cancer, and liver disease.
  • The findings suggest that measuring serum GGT levels could be beneficial for evaluating mortality risk in individuals with type 2 diabetes.
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  • Nivolumab, an immune checkpoint inhibitor, was tested alongside external beam radiation therapy (EBRT) for treating hepatocellular carcinoma (HCC) with macrovascular invasion, aiming to evaluate its efficacy and safety.* -
  • In a phase II trial involving 50 patients, the median progression-free survival (PFS) was 5.6 months, and overall survival was 15.2 months, with an objective response rate of 36% and a disease control rate of 74% observed.* -
  • While 80% of patients experienced treatment-related side effects, mostly mild (like pruritus and rash), the combination therapy demonstrated promising results, indicating that it can be a viable option for managing this type
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Liver transplantation is a highly complex and challenging field of clinical practice. Although it was originally developed in western countries, it has been further advanced in Asian countries through the use of living donor liver transplantation. This method of transplantation is the only available option in many countries in the Asia-Pacific region due to the lack of deceased organ donation.

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Background: Basophils are rare but important effector cells in many allergic disorders. Contrary to their early progenitors, the terminal developmental processes of basophils in which they gain their unique functional properties are unknown.

Objective: We sought to identify a novel late-stage basophil precursor and a transcription factor regulating the terminal maturation of basophils.

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Introduction: Long-term complications of chronic hepatitis B (CHB) viral infection, such as cirrhosis, hepatocellular carcinoma (HCC), and liver failure, cause a large disease burden. This study aimed to describe the epidemiology, clinical outcomes, and treatment patterns of CHB infection and co-infection with hepatitis D virus (HDV) in South Korea.

Methods: The retrospective, observational study used existing data from the Health Insurance Review and Assessment Service (HIRA) database.

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Transarterial chemoembolization (TACE) was introduced in 1977 with the administration of chemotherapeutic agent to gelatin sponge particles through the hepatic artery in patients with hepatocellular carcinoma (HCC) and was established as conventional TACE using Lipiodol in the 1980s. In the 2000s, drug-eluting beads were developed and applied clinically. Currently, TACE is a commonly used non-surgical treatment modality for patients with HCC who are unsuitable for curative treatment.

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Transarterial chemoembolization (TACE) was introduced in 1977 with the administration of chemotherapeutic agent to gelatin sponge particles through the hepatic artery in patients with hepatocellular carcinoma (HCC) and was established as conventional TACE using Lipiodol in the 1980s. In the 2000s, drug-eluting beads were developed and applied clinically. Currently, TACE is a commonly used non-surgical treatment modality for patients with HCC who are unsuitable for curative treatment.

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Transarterial chemoembolization (TACE) was introduced in 1977 with the administration of chemotherapeutic agent to gelatin sponge particles through the hepatic artery in patients with hepatocellular carcinoma (HCC) and was established as conventional TACE using Lipiodol in the 1980s. In the 2000s, drug-eluting beads were developed and applied clinically. Currently, TACE is a commonly used non-surgical treatment modality for patients with HCC who are unsuitable for curative treatment.

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Peritoneal seeding of hepatocellular carcinoma (HCC) is incurable and has poor prognosis. A 68-year-old man underwent surgical resection for a 3.5 cm single nodular HCC at the tip of segment 3 and transarterial chemoembolization for a 1.

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Introduction: Although an association between metabolic dysfunction-associated fatty liver disease (MAFLD) and cardiovascular disease or overall mortality has been reported, it is unclear whether there is an association between MAFLD and cancer incidence or mortality. We aimed to investigate the differential risk of all- and site-specific cancer incidence and mortality according to MAFLD subgroups categorized by additional etiologies of liver disease.

Methods: Using the Korean National Health Insurance Service database, we stratified the participants into three groups: (1) single-etiology MAFLD (S-MAFLD) or MAFLD of pure metabolic origin; (2) mixed-etiology MAFLD (M-MAFLD) or MAFLD with additional etiological factor(s) (i.

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Background: Alcohol and diabetes are known risk factors for hepatocellular carcinoma (HCC); however, it is unclear whether the association between alcohol consumption and HCC risk differs by fasting serum glucose level and diabetes. We investigated the dose-response relationship between alcohol consumption and the risk of HCC according to glycemic status.

Methods And Findings: This population-based observational cohort study included patients who underwent general health checkups in 2009 using the Korean National Health Insurance Service Database.

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Background And Purpose: The association between fatty liver and fracture risk has not been firmly established. In this study, we investigated the relationship between the fatty liver index (FLI) and the incidence of fractures among individuals ≥50 years of age, using a nationwide population-based cohort.

Methods: Data from the Korean National Health Insurance System between January 2009 and December 2019 were analyzed using the Cox proportional hazards model.

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Background/aims: Transarterial radioembolization (TARE) has shown promising results in treating advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). However, whether TARE can provide superior or comparable outcomes to tyrosine kinase inhibitor (TKI) in patients with HCC and PVTT remains unclear. We compared the outcomes of TARE and TKI therapy in treatment-naïve patients with locally advanced HCC and segmental or lobar PVTT.

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Synopsis of recent research by authors named "Yuri Cho"

  • - Yuri Cho's recent research primarily focuses on the prevalence and impact of nonalcoholic fatty liver disease (NAFLD) in various populations, particularly pediatrics and patients with obesity. His systematic reviews and meta-analyses highlight the increasing rates of NAFLD among adolescents as childhood obesity rises.
  • - His studies explore the relationship between NAFLD and cardiovascular conditions, such as atrial fibrillation, revealing potential age stratifications in risk assessment and the effects of hepatic fibrosis on these relationships.
  • - Cho also investigates the metabolic effects of antiviral treatments in chronic hepatitis B patients and assesses the effectiveness of bariatric interventions for improving metabolic dysfunction-related liver conditions, emphasizing the need for comprehensive strategies in managing liver health.

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