Neuronal metabolism in learning and memory: The anticipatory activity perspective.

Current research on the molecular mechanisms of learning and memory is based on the "stimulus-response" paradigm, in which the neural circuits connecting environmental events with behavioral responses are strengthened. By contrast, cognitive and systems neuroscience emphasize the intrinsic activity of the brain that integrates information, establishes anticipatory actions, executes adaptive actions, and assesses the outcome via regulatory feedback mechanisms. We believe that the difference in the perspectives of systems and molecular studies is a major roadblock to further progress toward understanding the mechanisms of learning and memory.

Analytic and Holistic Thinkers: Differences in the Dynamics of Heart Rate Complexity When Solving a Cognitive Task in Field-Dependent and Field-Independent Conditions.

Analytic and holistic thinking styles are known to be associated with individual differences in various aspects of behavior and brain activity. In this study, we tested a hypothesis that differences in thinking styles may also be manifested at the level of neuro-visceral coordination. Heart rate variability (HRV) was compared between analytic and holistic thinkers at rest, during a simple motor choice reaction time task and when solving cognitive choice reaction time tasks in conditions with varying instructions contrasting the role of the field when evaluating objects.

Complexity of heart rate variability during moral judgement of actions and omissions.

Recent research strongly supports the idea that cardiac activity is involved in the organisation of behaviour, including social behaviour and social cognition. The aim of this work was to explore the complexity of heart rate variability, as measured by permutation entropy, while individuals were making moral judgements about harmful actions and omissions. Participants (N = 58, 50% women, age 21-52 years old) were presented with a set of moral dilemmas describing situations when sacrificing one person resulted in saving five other people.

Reaction to norm transgressions and Islamization threat in culturally tight and loose contexts: a cross-cultural comparison of Germany versus Russia.

Prior research shows that North Americans and Western Europeans react to threats with defensive strategies based on behavioral approach vs. inhibition systems (BAS/BIS)-i.e.

Regression II. Development through regression.

As shown in our previous paper ('Regression I. Experimental approaches to regression', JAP, 65, 2, 345-65), the common mechanism of regression can be described as reversible dedifferentiation, which is understood as a relative increase of the proportion of low-differentiated (older) systems in actualized experience. Experimental data show that regression following disease (chronic tension headache) is followed by adaptation and an increase in system differentiation in that experience domain which contains systems responsible for that adaptation.

Regression I. Experimental approaches to regression.

The concept of regression is considered with an emphasis on the differences between the positions of Freud and Jung regarding its significance. The paper discusses the results of experimental analyses of individual experience dynamics (from gene expression changes and impulse neuronal activity in animals to prosocial behaviour in healthy humans at different ages, and humans in chronic pain) in those situations where regression occurs: stress, disease, learning, highly emotional states and alcohol intoxication. Common mechanisms of regression in all these situations are proposed.

A drama movie activates brains of holistic and analytical thinkers differentially.

People socialized in different cultures differ in their thinking styles. Eastern-culture people view objects more holistically by taking context into account, whereas Western-culture people view objects more analytically by focusing on them at the expense of context. Here we studied whether participants, who have different thinking styles but live within the same culture, exhibit differential brain activity when viewing a drama movie.

Neuronal Bases of Systemic Organization of Behavior.

Despite the years of studies in the field of systems neuroscience, functions of neural circuits and behavior-related systems are still not entirely clear. The systems description of brain activity has recently been associated with cognitive concepts, e.g.

Activity during Learning and the Nonlinear Differentiation of Experience.

Walter Freeman's work emphasises the role of individual activity and intentionality as opposed to the traditional stimulus-reaction view and the machine metaphor. The results of our computer modeling studies suggest the nonlinear dynamics of experience emerging from perception-action cycles. We consider the perception-action cycle as a behavioral continuum of anticipated outcomes of actions.

Sociocultural Influences on Moral Judgments: East-West, Male-Female, and Young-Old.

Gender, age, and culturally specific beliefs are often considered relevant to observed variation in social interactions. At present, however, the scientific literature is mixed with respect to the significance of these factors in guiding moral judgments. In this study, we explore the role of each of these factors in moral judgment by presenting the results of a web-based study of Eastern (i.

Mental Reactivation and Pleasantness Judgment of Experience Related to Vision, Hearing, Skin Sensations, Taste and Olfaction.

Language acquisition is based on our knowledge about the world and forms through multiple sensory-motor interactions with the environment. We link the properties of individual experience formed at different stages of ontogeny with the phased development of sensory modalities and with the acquisition of words describing the appropriate forms of sensitivity. To test whether early-formed experience related to skin sensations, olfaction and taste differs from later-formed experience related to vision and hearing, we asked Russian-speaking participants to categorize or to assess the pleasantness of experience mentally reactivated by sense-related adjectives found in common dictionaries.

Expression of c-Fos in the rat retrosplenial cortex during instrumental re-learning of appetitive bar-pressing depends on the number of stages of previous training.

Learning is known to be accompanied by induction of c-Fos expression in cortical neurons. However, not all neurons are involved in this process. What the c-Fos expression pattern depends on is still unknown.

Nonlinear relationship between emotional valence and brain activity: evidence of separate negative and positive valence dimensions.

Emotion plays a significant role in goal-directed behavior, yet its neural basis is yet poorly understood. In several psychological models the cardinal dimensions that characterize the emotion space are considered to be valence and arousal. Here 3T functional magnetic resonance imaging (fMRI) was used to reveal brain areas that show valence- and arousal-dependent blood oxygen level dependent (BOLD) signal responses.

Effect of emotional context in auditory-cortex processing.

We examined how emotional context influences processing of emotionally neutral acoustic stimuli in the human auditory cortex. Nine subjects performed a simple discrimination task. In the positive-emotional trials correct performance was awarded with money, whereas in the negative-emotional trials, correct performance resulted in avoidance of the loss of money.

Emotion and consciousness: ends of a continuum.

We suggest a united concept of consciousness and emotion, based on the systemic cognitive neuroscience perspective regarding organisms as active and goal-directed. We criticize the idea that consciousness and emotion are psychological phenomena having quite different neurophysiological mechanisms. We argue that both characterize a unified systemic organization of behavior, but at different levels.