The altered metabolic pathways of diffuse large B-cell lymphoma not otherwise specified.

Altered metabolic fingerprints of Diffuse large B-cell lymphoma, not otherwise specified (DLBCL NOS) may offer novel opportunities to identify new biomarkers and improve the understanding of its pathogenesis. This study aimed to investigate the modified metabolic pathways in extranodal, germinal center B-cell (GCB) and non-GCB DLBCL NOS from the head and neck. Formalin-fixed paraffin-embedded (FFPE) tissues from eleven DLBCL NOS classified according to Hans' algorithm using immunohistochemistry, and five normal lymphoid tissues (LT) were analyzed by high-performance liquid chromatography-mass spectrometry-based untargeted metabolomics.

Converting recycled membranes into photocatalytic membranes using greener TiO-GRAPHENE oxide nanomaterials.

Despite the widespread use of membrane separation processes for water treatment, operation costs and fouling still restrict their application. Costs can be overcome by recycled membranes whereas fouling can be mitigated by membrane modification. In this work, the performance of recycled reverse osmosis membranes modified by greener titanium dioxide (TiO) and graphene oxide (GO) in different modification routes were investigated and compared.

Integrated proteomics, phosphoproteomics and metabolomics analyses reveal similarities among giant cell granulomas of the jaws with different genetic mutations.

Background: Giant cell granuloma of the jaws are benign osteolytic lesions of the jaws. These lesions are genetically characterized by mutually exclusive somatic mutations at TRPV4, KRAS, and FGFR1, and a fourth molecular subgroup which is wild-type for the three mutations. Irrespective of the molecular background, giant cell granulomas show MAPK/ERK activation.

Age-Related Metabolic Pathways Changes in Dental Follicles: A Pilot Study.

Aging is not a matter of choice; it is our fate. The "time-dependent functional decline that affects most living organisms" is coupled with several alterations in cellular processes, such as cell senescence, epigenetic alterations, genomic instability, stem cell exhaustion, among others. Age-related morphological changes in dental follicles have been investigated for decades, mainly motivated by the fact that cysts and tumors may arise in association with unerupted and/or impacted teeth.

Influence of humic substances on the landfill leachate biodegradability with a focus on temporal seasonality.

The high resilience to biological treatments from the landfill leachate is generally associated with the presence of humic substances (HS). The brown color characteristic of this effluent is also related to these substances. Landfill leachate with low biodegradability can make biological treatments unfeasible, which can drive up the cost for the treatment of large leachate volumes.

Biodegradability, environmental risk assessment and ecological footprint in wastewater technologies for pharmaceutically active compounds removal.

Several studies have investigated the removal of pharmaceutically active compounds (PhACs) by wastewater treatment technologies due to the risk that these compounds pose to the environment. In this sense, advanced biological processes have been developed for micropollutants removal, such as membrane bioreactors and moving bed biofilm reactors. Thus, this review holistically evaluated the biodegradation of 18 environmentally hazardous PhACs.

Norfloxacin and gentamicin degradation catalyzed by manganese porphyrins under mild conditions: the importance of toxicity assessment.

The current work assessed the degradation degree and the degradation products derived from norfloxacin (NOR) and gentamicin (GEN) using iodosylbenzene and iodobenzene diacetate, in the presence of manganese porphyrin as catalysts. Better results for NOR degradation (> 80%) were obtained when more hydrophobic porphyrins were employed. β-brominated manganese porphyrins showed a lower GEN degradation (~ 25%) than the non-brominated ones (~ 35%), probably due to their steric hindrance.

Phenolic compounds in surface water: methodology and occurrence in Doce River, Brazil.

Phenolic compounds are widely spread in surface water, mainly in developing countries, where sewage and wastewater treatment are still reduced. Thus, this work quantified these pollutants in the Doce River analyzing the associated risk for the environment and human health. This river is in the state of Minas Gerais in Brazil and was recently impacted by the collapse of a mining dam that compromised the resilience of the entire watershed.

A survey on experiences in leachate treatment: Common practices, differences worldwide and future perspectives.

The necessity for landfill leachate treatment is a requisite to reduce the environmental impact related to municipal solid waste landfills and different aspects must be considered while deciding for an appropriate treatment process. For example, it was demonstrated that the landfill leachate stabilization in tropical regions is achieved right after its first year of operation, requiring technologies capable of treating leachates of a higher recalcitrant character if compared to those leachates from temperate regions and same landfill age. In view of its complexity and variability, stand-alone processes (either biological or physicochemical) are often ineffective in attaining the threshold values for its discharge in receiving bodies.

The environmental risks of pharmaceuticals beyond traditional toxic effects: Chemical differences that can repel or entrap aquatic organisms.

The aim of the present study was to assess the risks of four different pharmaceutical active compounds (PhACs; diazepam, metformin, omeprazole and simvastatin). Acute and chronic toxicities were studied using the bacterium Aliivibrio fischeri and the microalgae Pseudokirchneriella subcapitata; while the repellency and attractiveness were assessed by avoidance tests with juvenile Cypirinus carpio using a multi-compartmented exposure system. Omeprazole was found to be an acutely toxic drug (EC: 0.

Occurrence and risk assessment of pharmaceutically active compounds in water supply systems in Brazil.

The presence of pharmaceutically active compounds (PhACs) in water supply systems has been generating great concern about their effects on the environment and human health. Twenty-eight PhACs were monitored during one year in four Brazilian water sources, aiming to understand the factors that influence their occurrence and removal in conventional drinking water treatment plants (DWTPs) and to assess the environmental and human health risks. Trace levels of PhACs were detected in surface and drinking water in all assessed water sources.

Diazepam, metformin, omeprazole and simvastatin: a full discussion of individual and mixture acute toxicity.

High consumption of drugs, combined with their presence in the environment, raises concerns about its consequences. Even though researches are often engaged in analyzing substances separately, that is not the environmental reality. Therefore, the aim of this study was to investigate the acute toxicity of the pharmaceuticals simvastatin, metformin, omeprazole and diazepam, and all possible mixtures between them, to the organism Aliivibrio fischeri, verifying possible synergistic or antagonistic effects and assessing byproducts formation.

Graphene oxide in the remediation of norfloxacin from aqueous matrix: simultaneous adsorption and degradation process.

In the present study, the simultaneous adsorption degradation of norfloxacin (NOR) by graphene oxide from aqueous matrix was verified. Graphene oxide (GO, ~ 8 layers) was prepared using modified Hummers method through the oxidation/exfoliation of expanded graphite. Spectroscopic techniques confirmed the NOR adsorption onto GO surface and the partial antibiotic degradation promoted by hydroxyl radicals derived from GO.

Biosorption of methylene blue and eriochrome black T onto the brown macroalgae : equilibrium, kinetics, thermodynamics and optimization.

The present study had the objective to investigate the equilibrium, kinetics, thermodynamic viability and system optimization of methylene blue (MB) and eriochrome black T (ET) biosorption onto (). A comprehensive bioadsorbent characterization was carried out. The infrared spectra suggested a physical biosorption mechanism that was later proven by the enthalpy change and the isotherms models.