Publications by authors named "Yuri A Abramov"
Article Synopsis
- The nascent polypeptide-associated complex (NAC) is a crucial ribosome-associated protein involved in protein folding and sorting, and it is conserved across eukaryotic organisms.
- Researchers have identified germline-specific NACαβ paralogs (gNACs), which have unique protein structures in their α and β subunits, particularly longer regions that may be phosphorylated.
- The study suggests that these gNACs play a role in the coordination of protein regulation within germline cells, and there appears to be an interaction between gNACs and the commonly expressed NAC subunits that impacts organismal development.
Eukaryotic chromosomes are spatially segregated into topologically associating domains (TADs). Some TADs are attached to the nuclear lamina (NL) through lamina-associated domains (LADs). Here, we identified LADs and TADs at two stages of Drosophila spermatogenesis - in bamΔ86 mutant testes which is the commonly used model of spermatogonia (SpG) and in larval testes mainly filled with spermatocytes (SpCs).
View Article and Find Full Text PDFEukaryotic genomes harbor hundreds of rRNA genes, many of which are transcriptionally silent. However, little is known about selective regulation of individual rDNA units. In Drosophila melanogaster, some rDNA repeats contain insertions of the R2 retrotransposon, which is capable to be transcribed only as part of pre-rRNA molecules.
View Article and Find Full Text PDFIn the Drosophila ovary, somatic escort cells (ECs) form a niche that promotes differentiation of germline stem cell (GSC) progeny. The piRNA (Piwi-interacting RNA) pathway, which represses transposable elements (TEs), is required in ECs to prevent the accumulation of undifferentiated germ cells (germline tumor phenotype). The soma-specific piRNA cluster flamenco (flam) produces a substantial part of somatic piRNAs.
View Article and Find Full Text PDFPiwi in a complex with Piwi-interacting RNAs (piRNAs) triggers transcriptional silencing of transposable elements (TEs) in Drosophila ovaries, thus ensuring genome stability. To do this, Piwi must scan the nascent transcripts of genes and TEs for complementarity to piRNAs. The mechanism of this scanning is currently unknown.
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- Polytene chromosomes in D. melanogaster exhibit underrepresentation of heterochromatic pericentric regions, specifically in relation to the X-linked Stellate repeats.
- The study reveals that when a Stellate cluster fragment is transposed into euchromatin, it gets replicated in polytene chromosomes, particularly those near newly formed eu-heterochromatic boundaries.
- Internal rearrangements of the distal Xh don't impact Stellate replication, but trans effects from heterochromatic regions can influence the replication of these rearranged sequences, suggesting a role for heterochromatic proteins in their underrepresentation.
The therapeutic benefits of the antidepressant nefazodone have been hampered by several cases of acute hepatotoxicity/liver failure. Although the mechanism of hepatotoxicity remains unknown, it is possible that reactive metabolites of nefazodone play a causative role. Studies were initiated to determine whether nefazodone undergoes bioactivation in human liver microsomes to electrophilic intermediates.
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