Non-episodic angioedema with eosinophilia as a differential diagnosis of eosinophilia in young females.

Background: Episodic angioedema with eosinophilia, also known as Gleich's syndrome, is a differential diagnosis in patients with recurrent angioedema with higher blood eosinophils. Meanwhile, less has been elucidated regarding non-episodic angioedema with eosinophilia (NEAE). This study aimed to examine the prevalence, clinical characteristics, and disease course of NEAE.

Progranulin derivative attenuates lung neutrophilic infiltration from diesel exhaust particle exposure.

Background: Air pollutants, such as diesel exhaust particles (DEPs), induce respiratory disease exacerbation with neutrophilic infiltration. Progranulin (PGRN), an epithelial cell and macrophage-derived secretory protein, is associated with neutrophilic inflammation. PGRN is digested into various derivatives at inflammatory sites and is involved in several inflammatory processes.

Novel metabolites from the Mariana Trench-derived fungus sp. SY2250.

Four previously undescribed compounds talaromyester A () and purpuresters C-E (), together with known purpurester A () and purpuride G (), were isolated from the metabolites produced by the Mariana Trench sediment-derived fungus sp. SY2250. Compounds , two pairs of racemates, were separated on a chiral HPLC column.

Antimicrobial metabolites from the marine-derived fungus Aspergillus sp. ZZ1861.

Fungi from the genus Aspergillus are important resources for the discovery of bioactive agents. This investigation characterized the isolation, structural elucidation, and antimicrobial evaluation of 46 metabolites produced by the marine-derived fungus Aspergillus sp. ZZ1861 in rice solid and potato dextrose broth liquid media.

Isolation and Structure Elucidation of New Metabolites from the Mariana-Trench-Associated Fungus sp. SY2601.

Fungi are important resource for the discovery of novel bioactive natural products. This study investigated the metabolites produced by Mariana-Trench-associated fungus sp. SY2601 in EY liquid and rice solid media, resulting in the isolation and structure determination of 28 metabolites, including five new compounds, asperindopiperazines A-C (-), 5-methoxy-8,9-dihydroxy-8,9-deoxyaspyrone (), and 12-aspertetranone D ().

Exacerbation of pulmonary infection by comorbid allergic asthma is associated with diminished mycobacterium-specific Th17 responses.

Accumulating evidence suggests that two chronic respiratory diseases, nontuberculous mycobacterium (NTM)-pulmonary disease (PD) and allergic asthma, are frequently present together and that they likely influence the disease development and progression of each other. However, their precise interactions regarding the pathogenesis of comorbid diseases versus that of individual diseases are not well understood. In this study, comorbid diseases ( (Mav) pulmonary infection (PI) (Mav-PI) and ovalbumin-induced allergic asthma) were established in mice in different orders and at different time periods.