Publications by authors named "Yuqun A Luo"
A roadmap to using randomization in clinical trials.
Vance W Berger Louis Joseph Bour Kerstine Carter Jonathan J Chipman Colin C Everett Yuqun Abigail Luo
BMC Med Res Methodol
August 2021
Article Synopsis
- Randomization is crucial in clinical trials as it reduces selection bias, ensures balanced treatment groups, and enhances the validity of statistical tests; the paper discusses various restricted randomization methods for improving these processes.
- The authors evaluate multiple restricted randomization procedures, analyzing their statistical properties such as balance and error rates, and comparing their effectiveness through simulations and real-life examples.
- The findings highlight that different procedures have varying strengths, especially when assumptions are violated, and emphasize the importance of covariate-adjusted analysis and careful selection of randomization methods, especially with small sample sizes.
Aim: Hereditary spastic paraplegia (HSP) are a genetically and clinically heterogeneous group of disorders. At present, 19 autosomal dominant loci for HSP have been mapped. We ascertained an American family of European descent segregating an autosomal dominant HSP associated with peripheral neuropathy.
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