Publications by authors named "Yuqiong Deng"
Article Synopsis
- The research explored how Tubastatin-A, a glucocorticoid receptor inhibitor, and MitoQ, an antioxidant, can reduce macrophage cell death caused by dexamethasone (DEX).
- The study treated macrophage cells with DEX along with Tubastatin-A or MitoQ, measuring various mitochondrial function indicators, including reactive oxygen species levels and apoptosis.
- Results showed DEX increased harmful mitochondrial processes that led to cell death, while both Tubastatin-A and MitoQ effectively reduced these negative effects and improved macrophage survival, suggesting potential clinical benefits.
Microglia are resident macrophages within the central nervous system, serving as the first responders to neuroinflammation. Glucocorticoids (GCs) may cause damage to brain tissue, but the specific mechanism remains unclear. This study was divided into two parts: a glucocorticoid receptor (GR) mitochondrial translocation intervention experiment and a mitochondrial oxidative stress inhibition experiment.
View Article and Find Full Text PDFObjectives: This study aims to investigate the expression patterns of mitochondrially encoded cytochrome c oxidase 1 (MT-CO1) in different organs and tissues of mice aged six and 18 weeks.
Materials And Methods: Six-week-old female mice (n=10) were considered young lupus model mice, and 18-week-old mice (n=10) were considered old lupus model mice. Additionally, six-week-old (n=10) and 39-week-old (n=10) female Balb/c mice were used as the young and old controls, respectively.
The rate-determining step of the oxygen evolution reaction based on a semiconductor photoanode is the formation of the OO bond. Herein, polyethylene glycol (PEG)-modified BiVO photoanodes are reported, in which protons can be transferred quickly due to the high proton conductivity of PEG, resulting in the acceleration of the OO bond formation rate. These are fully demonstrated by different kinetic isotope effect values.
View Article and Find Full Text PDFObjectives: We sought to analyse the expression characteristics of cytochrome C oxidase subunit I in mitochondrial of MRL/lpr lupus mice.
Methods: The whole blood of MRL/lpr lupus mice was detected for whole mitochondrial genome sequencing performed by Illumina HiSeq PE150 instrument, compared with house mouse (NC_005089.1) and screened for the maximum difference gene, MT-CO1.