Publications by authors named "Yuqing Zhuang"
Article Synopsis
- Euphorbia L. is a traditional herb that contains compounds like Euphorbia factor L2 (EFL2), which has shown potential in reducing inflammation in conditions such as acute lung injury and arthritis.
- This study investigated the therapeutic effects of EFL2 on gouty arthritis by examining its impact on the NLRP3 inflammasome, using both in vitro and in vivo models.
- Results indicated that EFL2 inhibited the expression of NLRP3 and reduced inflammatory responses by binding to glucocorticoid receptors, suggesting its potential in developing new anti-inflammatory treatments.
Lathyrane-based diterpenoid is one of the critical bioactive elements of Euphorbia lathyris L., a widely used traditional Chinese medicine for the treatment of inflammation and infection. In this study, we introduced and evaluated seven synthetic or natural lathyrane-based diterpenoids with the same core structure but notable structural variations at specific positions, for their anti-inflammatory and gout-alleviating properties.
View Article and Find Full Text PDFThe aromatization mechanisms of ligustilide (1), a versatile monomeric phthalide, were investigated. DFT calculations combined with control experiments prove that the aromatization could result from direct oxidation by triplet oxygen in mild conditions with no catalyst, which is generally thought to be difficult. Moreover, it is predicted that the aromatization could rapidly clear away the harmful-to-organism singlet oxygen, which may be relevant to the general antioxidation activity of phthalides, providing a new point of view to understand the bioactivity from chemical reaction.
View Article and Find Full Text PDF