Publications by authors named "Yuqing Yang"

Herein, blue luminescent fluorescent poly(tannic acid) nanoparticles (FPTA NPs) were fabricated through chemical degradation of poly(tannic acid) large particles using HO, and the obtained FPTA NPs exhibited excellent water dispersibility, great fluorescence stability, and relatively high quantum yield. More importantly, based on the dynamic quenching and chelation enhanced quenching effect between FPTA NPs and bismuth ions (Bi), a fluorescence method for the rapid identification and detection of Bi was developed. With the increase of Bi, the fluorescence of FPTA NPs could be quenched gradually; the linear range was 0.

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The regulation of solution pH on the structural and optical properties of peptide self-assemblies remains a critical yet unresolved issue in peptide research. This study investigates the heptapeptide Ac-IHIHIQI-NH2 and its intrinsic fluorescence across a range of pH levels, demonstrating that variations in pH lead to significant changes in the morphology of the self-assembled structures. While the position of the fluorescence emission remains constant-due to the stability provided by the hydrogen bonding network of the peptide backbone-the intensity of the fluorescence exhibits a direct correlation with the degree of self-assembly.

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Background: Cognitive restructuring (CR) is an evidence-based psychological technique for depression. However, face-to-face CR is not easily accessible. Digital CR interventions often overlook the difficulties individuals experiencing depression encounter in identifying their negative automatic thoughts (NAT), leading to suboptimal outcomes.

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Antiferroelectric (AFE) ceramics are competitive energy storage candidates for advanced high-power devices. However, the poor recoverable energy density and efficiency are challenging and severely hinder their applications. Here, superior energy storage performance is obtained in Bi-, Sr-, and Ta-codoped AgNbO-based ceramics.

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  • The study explores how high-order interactions in non-small cell lung cancer (NSCLC) survival can reveal molecular mechanisms and potential treatments.
  • Previous research showed a significant three-way interaction involving smoking history and specific DNA methylation probes.
  • The current study identified a new four-way interaction that enhances survival prediction accuracy, contributing to understanding NSCLC progression.
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In the electrocatalytic CO reduction reaction (CORR), the strategic design of a catalytic well capable of regulating the overall confinement effects of catalytic sites holds significant promise for enhancing multiple-electron transfer and C─C coupling efficiency, particularly for the generation of C products. Here, a series of Cu-salphen-based covalent organic frameworks (COFs) featuring hydroxyl-induced catalytic well are synthesized, which demonstrate successful application in electrocatalytic CORR to yield multiple-electron transferred products. The meticulously engineered catalytic well, facilitated by multi-hydroxyl groups, manifests robust confinement effects, facilitating selective adsorption, enrichment, and activation of CO, intermediate stabilization, and reduction of energy barriers for electrocatalytic CORR.

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Isoliquiritigenin (ISL), a naturally occurring flavonoid derived from licorice root, exhibits antioxidant, anticancer, anti-inflammatory, and anti-allergic properties, and is frequently detected in both environmental and human samples. Previous studies from our lab have demonstrated that ISL exposure can lead to developmental deformities and aberrant immune responses. However, the molecular mechanisms underlying ISL toxicity in zebrafish embryos remain incompletely elucidated.

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We numerically investigate the optical bistability from a two-dimensional photonic crystal L6 nanocavity dimer array structure configured under the Su-Schrieffer-Heeger model. The localized electric field in the topological edge state is highly enhanced, which gives rise to strong nonlinear phenomena such as optical bistability. In comparison, a topologically trivial nanocavity is also designed and its field strength distribution and optical bistable response are also simulated.

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Gaultheria leucocarpa var. yunnanensis (Dianbaizhu) is a traditional Chinese herb for rheumatoid arthritis (RA). However, its macromolecular components have always been overlooked.

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Aqueous zinc metal batteries (AZMBs) have received widespread attention for large-scale sustainable energy storage due to their low toxicity, safety, cost-effectiveness. However, the technology and industrialization of AZMBs are greatly plagued by issues of Zn anode such as persistent dendrites and parasitic side reactions, resulting in rapid capacity degradation or battery failure. Electrochemically or chemically in-situ interfacial protection layers have very good self-adaption features for stability and reversibility of Zn anodes, which can also be well matched to current battery manufacturing.

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Aims: Heart failure with preserved ejection fraction (HFpEF) requires an efficient screening method. We developed a deep learning model (DLM) to screen HFpEF risk using electrocardiograms (ECGs).

Methods And Results: A cohort study was conducted utilising data from Cohorts A and B.

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Growth and yield (G&Y) of forest plantations can be significantly impacted by maladaptation resulting from climate change, and assisted migration has been proposed to mitigate these impacts by restoring populations to their historic climates. However, genecology models currently used for guiding assisted migration do not account for impacts of climate change on cumulative growth and assume that responses of forest population to climate do not change with age. Using provenance trial data for interior lodgepole pine ( subsp.

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The distinct molecular states - single molecule, assembly, and aggregate - of two ionic macromolecules, TPPE-APOSS and TPE-APOSS, are easily distinguishable through their tunable fluorescence emission wavelengths, which reflect variations in intermolecular distances. Both ionic macromolecules contain aggregation-induced emission (AIE) active moieties whose emission wavelengths are directly correlated to their mutual distances in solution: far away from each other as individual molecules, maintaining a tunable and relatively long distance in electrostatic interactions-controlled blackberry-type assemblies (microphase separation), or approaching van der Waals close distance in aggregates (macrophase separation). Furthermore, within the blackberry assemblies, the emission wavelength decreases monotonically with increasing assembly size, indicative of shorter intermolecular distances at nanoscale.

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The efficiency of valuable metabolite production by engineered microorganisms underscores the importance of stable and controllable gene expression. While plasmid-based methods offer flexibility, integrating genes into host chromosomes can establish stability without selection pressure. However, achieving site-directed multicopy integration presents challenges, including site selection and stability.

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Article Synopsis
  • Proteoglycans (PG) play an essential role in bone development by regulating collagen formation and mineralization, but existing PG-modified collagen scaffolds face challenges with infection resistance in clinical settings.
  • Researchers explored using proanthocyanidins (PA) to mimic PG functions and enhance the performance of scaffolds, while also providing antibacterial properties to combat infections during tissue regeneration.
  • The study found that while PA altered collagen fibril formation and mineralization when added at different stages, it ultimately improved scaffold features like hydrophilicity, degradation resistance, and biocompatibility, leading to enhanced bone regeneration outcomes in critical-size defect models.
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  • - Antibody-drug conjugates (ADCs) offer targeted cancer treatment, improving drug effectiveness while reducing side effects, but they can still cause toxicities from unintended targeting and payload release.
  • - Optimizing dosing regimens for ADCs requires a careful risk-benefit analysis, with exposure-response (E-R) analysis being essential for finding the right dose while managing safety and efficacy.
  • - The article reviews E-R analyses for all 12 FDA-approved ADCs in the U.S., highlighting shared safety and efficacy metrics and discussing dose optimization strategies crucial for developing cancer therapies.
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  • * A bilayer scaffold was created by combining a sulfonated PEEK framework with a hydrogel containing aspirin and nano-hydroxyapatite, which resulted in beneficial changes like better bioactivity and increased resistance.
  • * The bilayer scaffold demonstrated improved mechanical compatibility with bone and was shown to be biosafe, indicating its potential for effective clinical applications in bone regeneration.
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  • There's a big challenge in delivering chemotherapy drugs directly to tumors effectively.
  • Scientists are using tiny bubble-like structures called extracellular vesicles (EVs) to help deliver these drugs more safely.
  • A new type of EV, modified with a special peptide, can specifically target certain cancer cells, making it more effective and safer for normal cells compared to regular treatments.
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Background: The association between socioeconomic status and individual behaviors (SES/IB) and anxiety disorders has garnered increasing attention, yet the impact of SES/IB on anxiety disorders remains unclear. Therefore, we employed a Mendelian randomization (MR) design to evaluate the causal relationship between SES/IB and anxiety disorders.

Methods: We conducted a two-sample MR study to assess the causal effects of SES and IB (smoking behaviors, drinking behaviors, sleeping behaviors, habitual physical activity, leisure sedentary behaviors, and reproductive behaviors) on anxiety disorders.

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Translating natural language to visualization (NL2VIS) has shown great promise for visual data analysis, but it remains a challenging task that requires multiple low-level implementations, such as natural language processing and visualization design. Recent advancements in pre-trained large language models (LLMs) are opening new avenues for generating visualizations from natural language. However, the lack of a comprehensive and reliable benchmark hinders our understanding of LLMs' capabilities in visualization generation.

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The MuralDH dataset is an invaluable digital resource developed for the conservation and restoration of Dunhuang murals, which are critical components of global cultural heritage facing threats from degradation. This dataset comprises over 5000 high-resolution images tailored to 512 × 512 pixels, emphasizing the preservation of mural integrity and detail. It includes 1000 images with pixel-level damage annotations for segmentation research and 500 images specially processed for super-resolution studies, catering to a wide range of digital restoration needs.

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The visible light-induced decarboxylative cascade reaction of fluoroalkyl carboxylic acids has been achieved for the efficient synthesis of fluorinated compounds. However, most of the transformations rely on noble iridium metal complex. Herein, a visible light-induced metal-free decarboxylative cascade reaction of fluoroalkyl carboxylic acids has been realized.

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Macroion-counterion interaction is essential for regulating the solution behaviors of hydrophilic macroions, as simple models for polyelectrolytes. Here, we explore the interaction between uranyl peroxide molecular cluster LiK(OH)[UO(O)OH] (U) and multivalent counterions. Different from interaction with monovalent counterions that shows a simple one-step process, isothermal titration calorimetry, combined with light/X-ray scattering measurements and electron microscopy, confirm a two-step process for their interaction with multivalent counterions: an ion-pairing between U and the counterion with partial breakage of hydration shells followed by strong U-U attraction, leading to the formation of large nanosheets with severe breakage and reconstruction of hydration shells.

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We report a complex coacervate formed by a 2.5 nm-diameter, rigid uranyl peroxide molecular cluster (LiK(OH))[UO(O)OH], U) and SrCl salt in dilute aqueous solutions, including its location in the phase diagram, composition, rheological features, and critical conditions for phase transitions. In this coacervate, the Sr cations are a major building component, and the coacervate phase covers a substantial region of the phase diagram.

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Yersinia pseudotuberculosis (Yptb) is a pathogenic gram-negative bacterium that can colonize the intestines of different animals. Its infection leads to the activation of the host's innate immunity. Both host and bacterial-derived cyclic dinucleotides (CDNs) could activate the innate immune response of host cells.

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