COVID-19 impacts on characterization of N-nitrosamines and their precursors during transport in sewer systems.

During the COVID-19 outbreak, N-nitrosodimethylamine (NDMA) and N-nitrosomorpholine (NMOR) and their specific precursors (N,N-dimethylformamide [DMF] for NDMA and morpholine [MOR] for NMOR) were widely detected in sewerage systems of an urban area, in which chlorine-containing disinfectants were discharged with effluent of hospitals, etc. However, little is known about the effect of chlorine influx on formation and distribution of NDMA and NMOR in sewer systems in a sudden major public health event. We investigated the spatiotemporal patterns of NDMA, NMOR, DMF and MOR in influents of sewage treatment plants (STPs), as well as its upstream sewer sites during the COVID-19 pandemic.

 gen. et sp. nov. and distribution of an intron position class within .

, the largest order in , has a broad host range and inhabits host plants as epiphytes, endophytes, parasites and saprophytes. is a monophyletic family in , composed of species of deviated ecological background and morphological traits. In this study, we described a new fungal taxon under , based on root endophytic fungi recovered from the desert plant in Gansu Province, China.

The association between greenspace exposure and sperm quality: A retrospective cohort study focusing on sperm kinematics and the influence of buffer settings.

Background: While previous studies have suggested a potential link between greenspace and semen quality, the effect of greenspace exposure on sperm kinematics, as well as the impact of greenspace estimation scales, remains underexplored.

Objectives: This study aimed to examine the association between greenspace exposure and sperm kinematics, and to determine whether this relationship varies across different greenspace estimation scales.

Methods: We conducted a retrospective longitudinal study of 5025 semen measurements from 1674 sperm donors recruited by the Sichuan Provincial Human Sperm Bank (SHSB) between June 2019 and December 2021.

Characterization of potential bioactive molecules in Fissistigma polyanthum using UPLC-ESI-QTOF-MS-based metabolomics integrated with chemometrics approaches.

Fissistigma polyanthum is a renowned medicinal plant traditionally used by over 10 ethnic groups in China to treat various ailments, including inflammation. However, research on its chemical composition and bioactivity remains limited. This study investigated the chemical profiles and biological activities across different parts of F.

-altered mesenchymal tumor involving the parietal pleura: case report and literature review.

-altered mesenchymal tumors represent a rare category of soft tissue tumors that have recently been incorporated into the classification of head and neck soft tissue tumors in the fifth edition of the World Health Organization (WHO) classification. However, their precise nature remains undefined, and they have yet to be assigned an ICD code. These tumors are predominantly located in the head and neck region and display distinctive pathological morphology and molecular characteristics.

Identification of a novel hypermethylation marker, ZSCAN18, and construction of a diagnostic model in cervical cancer.

Purpose: Cervical cancer (CC), a common female malignancy, has been linked to alterations in DNA methylation. This study employed an integrated "dry-wet lab" strategy combining bioinformatics, machine learning, and experimental validation to identify novel methylation biomarkers for CC.

Methods: Methylome and transcriptome data from the TCGA and GEO cohorts (n=349 discovery, n=414 validation) were analyzed to identify differentially methylated CpGs.

Metabolic phenotypes and fatty acid profiles associated with histopathology of primary aldosteronism.

Primary aldosteronism (PA) caused by aldosterone hypersecretion is treated by adrenalectomy or medications. Histopathologic examination of resected adrenals reveals diverse histopathologic features. This study aimed to investigate the potential association of peripheral and adrenal tissue metabolic profiles with the histopathologic features of PA.

Comprehensive analysis of the circRNA expression profile and circRNA-miRNA-mRNA network in pelvic organ prolapse.

Pelvic organ prolapse (POP) is a common gynecological disease caused by pathological defects, lesions, or mechanical weakening of the support structures of the pelvic floor. However, its pathogenesis is unclear. Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules, which are thought to play an important role on skeletal muscle development by regulating gene expression.

Proteome differences of dental stem cells between permanent and deciduous teeth by data-independent acquisition proteomics.

Dental pulp stem cells hold significant prospects for tooth regeneration and repair. However, a comprehensive understanding of the molecular differences between dental pulp stem cells (DPSC, from permanent teeth) and stem cells from human exfoliated deciduous teeth (SHED, from deciduous teeth) remains elusive, which is crucial for optimizing their therapeutic potential. To address this gap, we employed a novel data-independent acquisition (DIA) proteomics approach to compare the protein expression profiles of DPSC and SHED.

Double Cross-linked Methacrylated Carboxymethyl Pea Starch Cryogels with Highly Compressive Elasticity and Hemostatic Function.

As an abundant renewable natural material, starch has attracted unprecedented interest in the biomedical field. Carboxylated starch particles have been investigated for topical hemostasis, but the powder may not provide physical protection or support for wounds. Here, we prepared macroporous cryogel sponges of methacrylated carboxymethyl starch (CM-ST-MA) containing a covalent and a calcium ionic double network.

Colloidal Design and Preparation of an Internal Electric Modulated Z-Scheme BiOI-CdS Heteronanostructure with Oxygen-Rich Vacancies.

Photoelectrochemical (PEC) water splitting offers an ideal strategy for the development of clean and renewable energy. However, its practical implementation is often inhibited by the high recombination rate of photogenerated charge carriers and the instability of photoanodes. Introducing defect engineering (such as oxygen vacancies) and constructing internal electric field-modulated Z-scheme heteronanostructures (HNs) can be considered as effective approaches to overcome these obstacles.

The effects of unified pooling arrangement on health inequity in China: a DID-RIF approach.

Background: To address the health inequity caused by decentralized management, China has introduced a provincial pooling system for urban employees' basic medical insurance. This paper proposes a research framework to evaluate similar policies in different contexts. This paper adopts a mixed-methods approach to more comprehensively and precisely capture the causal effects of the policy.

The association of activity patterns on female reproductive diseases: a prospective cohort study of UK biobank.

Objective: Little is known about the role of timing of physical activity in female reproductive disorders. These disorders include polycystic ovary syndrome (PCOS), heavy menstrual bleeding (HMB), endometriosis, infertility, and pregnancy-related disorders. This study aims to investigate the associations of activity patterns with female reproductive diseases.

Stress of polyethylene and polylactic acid microplastics on pakchoi（Brassica rapa subsp. chinensis） and soil bacteria: Biochar mitigation.

It remains essential to investigate the differences in phytotoxic effects between conventional and biodegradable microplastics (MPs). Furthermore, the mechanisms by which biochar mitigates the toxic effects of MPs on crops and soil remain poorly understood. The results of this research indicated that, compared to control treatment (CK), the application of 2 % polyethylene (PE) alone led to a significant reduction in the fresh weight of pakchoi by 36.

Cyclodextrin-based delivery systems for chemical and genetic drugs: Current status and future.

Cyclodextrins (CDs) are cyclic polysaccharides characterized by their unique hollow structure, making them highly effective carriers for pharmaceutical agents. CD-based delivery systems are extensively utilized to enhance drug stability, increase solubility, improve oral bioavailability, and facilitate controlled release and targeted delivery. This review initially provides a concise overview of nano drug delivery systems, followed by a detailed introduction of the structural features and benefits of CDs.

The R203M and D377Y mutations of the nucleocapsid protein promote SARS-CoV-2 infectivity by impairing RIG-I-mediated antiviral signaling.

The viral protein mutations can modify virus-host interactions during virus evolution, and thus alter the extent of infection or pathogenicity. Studies indicate that nucleocapsid (N) protein of SARS-CoV-2 participates in viral genome assembly, intracellular signal regulation and immune interference. However, its biological function in viral evolution is not well understood.

Supported Mindfulness-Based Self-Help Intervention as an Adjunctive Treatment for Rapid Symptom Change in Emotional Disorders: A Practice-Oriented Multicenter Randomized Controlled Trial.

Introduction: Rapid symptom relief is crucial for individuals with emotional disorders. The current study aimed to determine whether facilitator-supported mindfulness-based self-help (MBSH) intervention as an adjunctive treatment could provide rapid improvement for individuals with emotional disorders.

Methods: A practice-oriented randomized controlled trial was conducted on a sample of 302 patients with emotional disorders from four centers.

The effect of preoperative topical magnesium sulfate spraying in the oropharyngeal region on postoperative sore throat following gynecological laparoscopic surgery: a randomized clinical trial.

Background: Postoperative sore throat is a common complication following general anesthesia. This study aimed to investigate the impact of preoperative topical magnesium sulfate spraying in the oropharyngeal region on postoperative sore throat following gynecological laparoscopic surgery.

Methods: The study included 58 patients scheduled for gynecologic laparoscopic surgery at Xuzhou Medical University Affiliated Hospital.

Understanding and addressing the global impact: A systematic review and cross-sectional bibliometric analysis of Langya henipavirus and pre-existing severe henipaviruses.

In 2022, Langya henipavirus was identified in patients with fever in eastern China. This study provides an overview of the scientific landscape, highlights research focus areas, and outlines potential future investigations. The relevant scientific literature was systematically searched and reviewed via advanced bibliometric techniques.

Mixed exposure to PFOA and PFOS induces oocyte apoptosis and subfertility in mice by activating the Hippo signaling pathway.

Per- and polyfluoroalkyl substances (PFAS) are synthetic perfluorinated compounds known for their persistence in the environment and reproduction toxicity. PFAS, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), have been identified in the follicular fluid of infertile women. However, the specific of PFOA and PFOS mixture on oocyte quality and female fertility remain unclear.

Whole-Genome Sequencing and Genome Annotation of Pathogenic Causing Stem and Foliage Scab Disease in Sweet Potato.

A pathogen strain responsible for sweet potato stem and foliage scab disease was isolated from sweet potato stems. Through a phylogenetic analysis based on the rDNA internal transcribed spacer (ITS) region, combined with morphological methods, the isolated strain was identified as To comprehensively analyze the pathogenicity of the isolated strain from a genetic perspective, the whole-genome sequencing of HD-1 was performed using both the PacBio and Illumina platforms. The genome of HD-1 is about 26.

Epidemiological investigation and drug resistance analysis of avian pathogenic (APEC) of Wenchang chickens in Hainan, China.

Type O8 is the most prevalent serotype of APEC isolated from Wenchang chicken embryos (Hainan, China).The isolates were more than 90% resistant to erythromycin, amoxicillin, ampicillin, and tetracycline.19.

SGSNet: a lightweight deep learning model for strawberry growth stage detection.

Introduction: Detecting strawberry growth stages is crucial for optimizing production management. Precise monitoring enables farmers to adjust management strategies based on the specific growth needs of strawberries, thereby improving yield and quality. However, dense planting patterns and complex environments within greenhouses present challenges for accurately detecting growth stages.

Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers.

First-line immune checkpoint inhibitor (ICI) combinations show responses in subsets of hepatocellular carcinoma (HCC) patients. Nearly half of HCCs are Wnt-active with mutations in (encoding for β-catenin), , or , and demonstrate limited benefit to ICI due to an immune excluded tumor microenvironment. We show significant tumor responses in multiple β-catenin-mutated immunocompetent HCC models to a novel siRNA encapsulated in lipid nanoparticle targeting (LNP-CTNNB1).

Characterization of Cardiac Troponin Fragment Composition Reveals Potential for Differentiating Etiologies of Myocardial Injury.

Background: Increased cardiac troponin (cTn) concentrations occur in acute myocardial injury and chronic diseases. Characterization of cTn composition in the circulation may assist in differentiating etiologies of myocardial injury. Our goal was to study cTn composition and kinetics in patients following type 1 myocardial infraction (T1MI), cardiac procedures, and chronic heart diseases to establish the relationship between cTn composition and clinical diagnosis.