Aberrant regional neural fluctuations and functional connectivity in insomnia comorbid depression revealed by resting-state functional magnetic resonance imaging.

Insomnia is a common mental illness seriously affecting people lives, that might progress to major depression. However, the neural mechanism of patients with CID comorbid MDD remain unclear. Combining fractional amplitude of low-frequency fluctuation (fALFF) and seed-based functional connectivity (FC), this study investigated abnormality in local and long-range neural activity of patients with CID comorbid MDD.

LLGL2 targets the Hedgehog signaling pathway to influence malignant progression of endometrial cancer.

Background: Endometrial cancer (EC) is a malignant tumor of the endometrial epithelium, with endometrial adenocarcinoma being the most common type. It has a good overall prognosis, but recurrence and metastasis are often associated with poorer outcomes. LLGL2 is closely linked to tumorigenesis; however, its in endometrial carcinoma is unknown.

The brain in chronic insomnia and anxiety disorder: a combined structural and functional fMRI study.

Background: Chronic insomnia disorder (CID) is usually associated with Generalized Anxiety Disorder (GAD), which may change brain structure and function. However, the possible brain markers, imaging characteristics, and pathophysiology are unknown.

Objective: To look at the probable brain markers, imaging characteristics, and pathogenesis of CID in combination with GAD.

Liraglutide Improves PCOS Symptoms in Rats by Targeting FDX1.

Background: Polycystic ovary syndrome (PCOS) is a gynecological endocrine disorder characterized by ovulatory disorders, hyperandrogenemia, and polycystic changes in the ovaries. FDX1 is a ferredoxin-reducing protein on human mitochondria that plays an important role in steroid anabolism. Liraglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has recently emerged as a potential therapeutic agent for PCOS.

Foam fractionation and electrochemical oxidation for the treatment of per- and polyfluoroalkyl substances (PFAS) in environmental water samples.

Treatment of waters contaminated by per- and polyfluoroalkyl substances (PFAS) in large volumes remains a challenge to date. Treatment trains comprising separation and destruction technologies are promising to manage PFAS contamination. Foam fractionation (FF) and electrochemical oxidation (EO) are two cost-effective technologies for PFAS separation and destruction, respectively.

Cerebellum and hippocampus abnormalities in patients with insomnia comorbid depression: a study on cerebral blood perfusion and functional connectivity.

Chronic insomnia disorder and major depressive disorder are highly-occurred mental diseases with extensive social harm. The comorbidity of these two diseases is commonly seen in clinical practice, but the mechanism remains unclear. To observe the characteristics of cerebral blood perfusion and functional connectivity in patients, so as to explore the potential pathogenesis and biological imaging markers, thereby improving the understanding of their comorbidity mechanism.

Aberrant structural and functional alterations in postpartum depression: a combined voxel-based morphometry and resting-state functional connectivity study.

Objectives: Postpartum depression (PPD) is a severe postpartum psychiatric disorder with unclear pathogenesis. Previous neuroimaging studies have reported structural or functional alterations in areas associated with emotion regulation, cognitive disorder, and parenting behaviors of PPD. The primary goal of this investigation was to explore the presence of brain structural alterations and relevant functional changes in PPD patients.

Segment aorta and localize landmarks simultaneously on noncontrast CT using a multitask learning framework for patients without severe vascular disease.

Background: Non-contrast chest CT is widely used for lung cancer screening, and its images carry potential information of the thoracic aorta. The morphological assessment of the thoracic aorta may have potential value in the presymptomatic detection of thoracic aortic-related diseases and the risk prediction of future adverse events. However, due to low vasculature contrast in such images, visual assessment of aortic morphology is challenging and highly depends on physicians' experience.

An Environmentally Sustainable Software-Defined Networking Data Dissemination Method for Mixed Traffic Flows in RSU Clouds with Energy Restriction.

The connected multi road side unit (RSU) environment can be envisioned as the RSU cloud. In this paper, the Software-Defined Networking (SDN) framework is utilized to dynamically reconfigure the RSU clouds for the mixed traffic flows with energy restrictions, which are composed of five categories of vehicles with distinctive communication demands. An environmentally sustainable SDN data dissemination method for safer and greener transportation solutions is thus proposed, aiming to achieve the lowest overall SDN cloud delay with the least working hosts and minimum energy consumption, which is a mixed integer linear programming problem (MILP).

Removing per- and polyfluoroalkyl substances (PFAS) in water by foam fractionation.

Treatment of large volumes of waters contaminated by per- and polyfluoroalkyl substances (PFAS) remains a challenge. This work presented a systematic study on PFAS removal by foam fractionation (FF). Experiments were conducted on both laboratory-spiked and environmental water samples containing PFASs.

Infrared Sensation-Based Salient Targets Enhancement Methods in Low-Visibility Scenes.

Thermal imaging is an important technology in low-visibility environments, and due to the blurred edges and low contrast of infrared images, enhancement processing is of vital importance. However, to some extent, the existing enhancement algorithms based on pixel-level information ignore the salient feature of targets, the temperature which effectively separates the targets by their color. Therefore, based on the temperature and pixel features of infrared images, first, a threshold denoising model based on wavelet transformation with bilateral filtering (WTBF) was proposed.

Effect of long working hours and insomnia on depressive symptoms among employees of Chinese internet companies.

Background: In China, long working hours and insomnia are relatively common among internet company employees. Considering that both can affect mental health, we examined their independent and interaction effects on these employees' depressive symptoms (DS).

Methods: We analyzed data from the 2016 occupational health questionnaire survey conducted in 35 large-, medium-, and small-scale internet companies.

Use of three-dimensional-printed custom-made prosthesis to treat unicondylar femoral defect secondary to pathological fracture caused by giant cell tumor.

Objective: To evaluate the short-term effectiveness of using a three-dimensional (3D)-printed custom-made prosthesis to repair unicondylar femoral defects.

Methods: We retrospectively reviewed 26 patients with a primary pathological fracture of the distal femur caused by a giant cell tumor. All patients had unicondylar defects involving the articular surface.

Improving the biotransformation of phytosterols to 9α-hydroxy-4-androstene-3,17-dione by deleting embC associated with the assembly of cell envelope in Mycobacterium neoaurum.

The conversion of low value-added phytosterols into 9α-hydroxy-4-androstene-3,17-dione (9-OHAD) by mycobacteria is an important step in the steroid pharmaceutical industry. However, the highly dense cell envelope with extremely low permeability largely affects the overall transformation efficiency. Here, we preliminarily located the key gene embC required for the synthesis of lipoarabinomannan from lipomannan in Mycobacterium neoaurum.

An Online Classification Method for Fault Diagnosis of Railway Turnouts.

Railway turnout system is a key infrastructure to railway safety and efficiency. However, it is prone to failure in the field. Therefore, many railway departments have adopted a monitoring system to monitor the operation status of turnouts.

Influence of Prolonged Visual Display Terminal Use and Exercise on Physical and Mental Conditions of Internet Staff in Hangzhou, China.

To examine the effects of prolonged visual display terminal (VDT) working hours and exercise frequency on VDT-related symptoms, we recruited 944 Chinese internet staff for the study. A self-administered questionnaire survey was used to obtain the hours of daily VDT work, exercise frequency, and the physical and mental health of the participants. The daily VDT working time of participants was 8.

miR-143 inhibits proliferation and metastasis of nasopharyngeal carcinoma cells via targeting FMNL1 based on clinical and radiologic findings.

Mounting evidence has reported that microRNA-143 (miR-143) is involved in the development of multiple cancers. To investigate the underlying mechanisms of miR-143 regulating proliferation and metastasis in nasopharyngeal carcinoma (NPC) cells, we evaluated the levels of miR-143 and formin-like protein 1 (FMNL1) in NPC tissues. The results of qRT-PCR and Western blot analysis showed that the expression of miR-143 was decreased, while FMNL1 was increased in NPC tissues.

Differentiation of nestin‑negative human hair follicle outer root sheath cells into neurons in vitro.

A specialized quiescent population of hair follicle stem cells, residing in the hair follicle outer root sheath cells (ORSCs), has previously demonstrated pluripotency for differentiation into neural stem cells (NSCs). A previous study indicated that nestin‑positive hair follicle ORSCs are able to differentiate into neurons. However, little has been reported on the isolation of nestin‑negative human ORSCs and whether they can successfully differentiate into neurons in vitro.

Using the Job Burden-Capital Model of Occupational Stress to Predict Depression and Well-Being among Electronic Manufacturing Service Employees in China.

Background: This study aimed to identify the association between occupational stress and depression-well-being by proposing a comprehensive and flexible job burden-capital model with its corresponding hypotheses.

Methods: For this research, 1618 valid samples were gathered from the electronic manufacturing service industry in Hunan Province, China; self-rated questionnaires were administered to participants for data collection after obtaining their written consent. The proposed model was fitted and tested through structural equation model analysis.

[Optimization of primary hepatocytes model and study on the cytotoxicity of styrene and styrene oxide].

Objective: To establish a model in vitro for primary cultured mouse hepatocytes with high viability and function, and evaluate the acute toxicity of the primary hepatocytes exposed to the chemicals such as styrene and styrene oxide (SO).

Methods: Based on the classical method, the two-step collagenase digestion method was optimized by reverse and intermittent perfusion, restriction of digestion time as well as purification of percoll liquid. Hepatocytes were isolated from BALB/C mouse by an improved isolated method and then cultured in monolayer and sandwich configuration.

[Design and experimental study of an epiphyseal slide-traction plate].

Objective: To develop an epiphyseal slide-traction plate in child, which can supply the fracture a sufficient internal fixation, and will not restrain the growth of epiphyses. Animal experiments were carried out with the plates to compare the slide-traction with traditional plate.

Methods: Develop a slide-traction plate for the configuration of the femur condylus of children.