Publications by authors named "Yuqing Dan"
Article Synopsis
- CDK9 plays a key role in cancer transcription and is a potential target for anti-cancer treatments, especially for blood cancers.
- Inhibition of CDK9 reduces α-tubulin protein levels and promotes its degradation due to decreased acetylation, which is vital for microtubule stability.
- The study reveals that CDK9 inhibitors downregulate the acetyltransferase ATAT1, compromising microtubule stability and highlighting a new therapeutic mechanism for CDK9 inhibitors in cancer treatment.
IRF8 is a key regulator of innate immunity receptor signaling and plays diverse functions in the development of hematopoietic cells. The effects of IRF8 on hematopoietic stem cells (HSCs) are still unknown. Here, it is demonstrated that IRF8 deficiency results in a decreased number of long-term HSCs (LT-HSCs) in mice.
View Article and Find Full Text PDFBackground: Several studies have been conducted to investigate the association between the presence of perineural invasion (PNI) and overall survival (OS) of gastric cancer (GC) patients who underwent curative resection, but no consensus has been reached. This study is aimed at determining the prognostic significance of PNI in gastric cancer. .
View Article and Find Full Text PDFThe predictors of weaning time of renal replacement therapy (RRT) remain controversial for special patients suffering from acute kidney injury (AKI). The present work aims to perform a meta-analysis to evaluate proper predictors of RRT weaning in AKI patients. We systematically searched EMBASE, PubMed, and Cochrane Central Register of Controlled trials for literatures between 1984 and June 2019.
View Article and Find Full Text PDFBackground: Suprapancreatic lymphadenectomy is the essence of D2 radical gastric cancer surgery. The present study aimed to describe clockwise modularized laparoscopic lymphadenectomy in the suprapancreatic area.
Methods: The data from gastric cancer patients who underwent surgical treatment from September 2016 to December 2018 were collected.
Objective: The aim of the study was to identify the analgesic efficacy and safety of transcutaneous electronic nerve stimulation in postoperative pain after pulmonary surgery.
Design: Electronic databases (PubMed, Embase, Web of Science, and CENTRAL) were systematically searched from their inception to June 2019. The continuous variables were pooled as the weighted mean difference with correlated 95% confidence interval.