Boosting Electrocatalytic Oxygen Evolution: Superhydrophilic/Superaerophobic Hierarchical Nanoneedle/Microflower Arrays of CeCoO with Oxygen Vacancies.

The oxygen evolution reaction has become the bottleneck of electrochemical water splitting for its sluggish kinetics. Developing high-efficiency and low-cost non-noble-metal oxide electrocatalysts is crucial but challenging for industrial application. Herein, superhydrophilic/superaerophobic hierarchical nanoneedle/microflower arrays of Ce-substituted CoO (CeCoO) in situ grown on the nickel foam are successfully constructed.

Recognition and Selectivity Analysis Monitoring of Multicomponent Steroid Estrogen Mixtures in Complex Systems Using a Group-Targeting Environmental Sensor.

The same class of steroid estrogen mixtures, coexisting in the environment of 17β-estradiol, estrone (E1), and ethinyl estradiol (EE2), have strong ability to disrupt the human endocrine system and are seriously prejudicial to the health of the organism and environmental safety. Herein, a highly sensitive and group-targeting environmental monitoring sensor was fabricated for a comprehensive analysis of multicomponent steroid estrogens (multi-SEs) in complex systems. This breakthrough was based on the highly sensitive photoelectrochemical response composite material CdSe NPs-TiO nanotube and highly group-specific aptamers.

COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay.

Coatomer complexes function in the sorting and trafficking of proteins between subcellular organelles. Pathogenic variants in coatomer subunits or associated factors have been reported in multi-systemic disorders, i.e.

Physical Function and Clinical Outcomes in Hemodialysis Patients: China Dialysis Outcomes and Practice Patterns Study.

Background: Hemodialysis (HD) patients usually have impaired physical function compared with the general population. Self-reported physical function is a simple method to implement in daily dialysis care. This study aimed to examine the association of self-reported physical function with clinical outcomes of HD patients.

Heat-induced down-regulation of photosystem II protects photosystem I in honeysuckle (Lonicera japonica).

Honeysuckle (Lonicera japonica Thunb.) is a traditional medicinal plant in China which is often threatened by high temperature at midday during summer. Heat-induced effects on the photosynthetic apparatus in honeysuckle are associated with a depression of the photosystem II (PSII) photochemical efficiency.

PIWI-interacting RNAs are aberrantly expressed and may serve as novel biomarkers for diagnosis of lung adenocarcinoma.

Background: Lung adenocarcinoma (LUAD) is the main subtype of primary lung cancer and is a leading cause of cancer-related death worldwide. PIWI-interacting RNAs (piRNAs) are a type of small non-coding RNAs that may play crucial roles in cancer progression and serve as biomarkers for tumor detection. This study aimed to explore the expression profiles and diagnostic values of piRNAs in LUAD.

Two cases of sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD) syndrome in Chinese Han children caused by novel compound heterozygous variants of the TRNT1 gene.

Sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD) syndrome is a serious autosomal recessive genetic disease. So far, <40 cases have been reported worldwide, and only one case has been reported in China. The main clinical features of SIFD are sideroblastic or microcytic anemia, immune deficiency, and recurrent episodes of inflammation.

Continuous estimation of airway resistance in non-invasive ventilation.

Background: This study aimed to evaluate the accuracy of expiratory time constant (RC) to continuously calculate the airway resistance (R).

Material And Methods: A Respironics V60 ventilator was connected to a lung simulator for modeling different profiles of respiratory mechanics.

Results: During assisted ventilation, the respiratory system compliance (C) calculation was always overestimated in most lung models.

Structure-Activity Relationship and Molecular Docking of a Kunitz-Like Trypsin Inhibitor, Kunitzin-AH, from the Skin Secretion of .

Kunitz-like trypsin inhibitors are one of the most noteworthy research objects owing to their significance in pharmacological studies, including anticarcinogenic activity, obesity regulation and anticoagulation. In the current study, a novel Kunitz-like trypsin inhibitor, Kunitzin-AH, was isolated from the skin secretion of . The novel peptide displayed a modest trypsin inhibitory activity with the inhibitor constant () value of 1.

Simultaneous denitrification and desulfurization-S recovery of wastewater in trickling filters by bioaugmentation intervention based on avoiding collapse critical points.

In order to better achieve efficiently simultaneous desulfurization and denitrification/S recovery of wastewater, the intervention of sulfur oxidizing bacteria (SOB) and denitrifying bacteria (DNB) was employed to avoid the collapse critical points (the dramatically decrease of S/N removal efficiency) under the fluctuated load. With the assistance of DNB and SOB, collapse critical point of trickling filter (TF) was delayed from the P (105-114 d) to P stage (129-138 d). The treatment efficiency of nitrogen and sulfur was the highest with the S/N ratio of 3:1.

Downregulation of the PD-1/PD-Ls pathway in peripheral cells correlates with asbestosis severity.

Background: Asbestosis and silicosis are characterized by diffuse or nodular interstitial lung fibrosis resulting from exposure to asbestos or silica dust, respectively. This study was designed to detect programmed cell death protein (PD-1)/programmed death ligands (PD-Ls) expression in patients with asbestosis and silicosis and to explore the possible clinical significance of PD-1/PD-Ls expression in patients with the two diseases.

Methods: Thirty patients with asbestosis, 23 patients with silicosis and 25 healthy controls were consecutively recruited and provided informed consent to participate in the study.

Finite-time control of delay switched systems via input anti-bump switching.

This article devotes to the finite-time (FT) input anti-bump switching control (SC) issue for a kind of delay switched systems (DSSs). Our objective is to carry the FT control while bringing down possible large jumps in the control input. First, a formulation of the alleviation for the control signal jumps is given.

A Novel Mouse Model for SNP in Steroid Receptor Co-Activator-1 Reveals Role in Bone Density and Breast Cancer Metastasis.

The steroid receptor coactivator-1 (SRC-1) is a nuclear receptor co-activator, known to play key roles in both estrogen response in bone and in breast cancer metastases. We previously demonstrated that the P1272S single nucleotide polymorphism (SNP; P1272S; rs1804645) in SRC-1 decreases the activity of estrogen receptor in the presence of selective estrogen receptor modulators (SERMs) and that it is associated with a decrease in bone mineral density (BMD) after tamoxifen therapy, suggesting it may disrupt the agonist action of tamoxifen. Given such dual roles of SRC-1 in the bone microenvironment and in tumor cell-intrinsic phenotypes, we hypothesized that SRC-1 and a naturally occurring genetic variant, P1272S, may promote breast cancer bone metastases.

[Prospects and developments in the technologies of high frequency oscillatory ventilation].

The high frequency oscillatory ventilation (HFOV) is characterized with low tidal volume and low mean airway pressure, and can well support the breathing of the patients with respiratory diseases. Since the HFOV was proposed, it has been widely concerned by medical and scientific researchers. About the HFOV, this paper discussed its current research status and prospected its future development in technologies.

Development of novel quality control material based on CRISPR/Cas9 editing and xenografts for MLH1 protein deficiency testing.

Background: Mismatch repair deficiency (dMMR) status induced by MLH1 protein deficiency plays a pivotal role in therapeutic decision-making for cancer patients. Appropriate quality control (QC) materials are necessary for monitoring the accuracy of MLH1 protein deficiency assays used in clinical laboratories.

Methods: CRISPR/Cas9 technology was used to edit the MLH1 gene of GM12878Cas9 cells to establish MLH1 protein-deficient cell lines.

The importance of sialic acid, pH and ion concentration on the interaction of uromodulin and complement factor H.

Uromodulin (UMOD) can bind complement factor H (cFH) and inhibit the activation of complement alternative pathway (AP) by enhancing the cofactor activity of cFH on degeneration of C3b. UMOD, an N-glycans-rich glycoprotein, is expressed in thick ascending limb of Henle's loop where the epithelia need to adapt to gradient change of pH and ion concentration. ELISA-based cofactor activity of cFH and erythrocytes haemolytic assay was used to measure the impact of native and de-glycosylated UMOD on the functions of cFH.

Chronic lung inflammation and pulmonary fibrosis after multiple intranasal instillation of PM in mice.

Fine particulate matter (PM ) is an important component of air pollution and can induce lung inflammation and oxidative stress. We hypothesized that PM could play a role in the induction of pulmonary fibrosis. We examined whether multiple intranasal instillation of PM can induce pulmonary fibrosis in the mouse, and also investigated the underlying pro-fibrotic signaling pathways.

Kidney involvement in coronavirus-associated diseases (Review).

Since 2003, coronaviruses have caused multiple global pandemic diseases, including severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and coronavirus disease 2019 (COVID-19). Clinical and autopsy findings suggest that the occurrence of kidney injury during infection may negatively affect the clinical outcomes of infected patients. The authoritative model predicts that outbreaks of other novel coronavirus pneumonias will continue to threaten human health in the future.

Quantitative definitions of pain, CA19-9, and tumor size as high-risk features of resectable pancreatic cancer: a single-center retrospective cohort study.

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of malignant tumors with the worst prognosis. Surgery and adjuvant chemotherapy are the main treatments for resectable pancreatic cancer. For borderline resectable PDAC, neoadjuvant chemotherapy has been advised.

Development of a laser scanning projection system with a dual-diameter fitting method and particle swarm optimization.

Laser scanning projection can project outlines of assembled components onto a work surface accurately, which can improve assembly efficiency, and is widely applied in industry manufacturing. In order to achieve accurate calibration and projection, a mathematical model of the calibration process is developed, and the dual-diameter fitting method is proposed to extract the central positions of retroreflective targets. Then, a particle swarm optimization (PSO) algorithm is introduced to solve the coordinate transformation matrix between the world frame and the projector frame, and the optimal parameters of the PSO algorithm are obtained to improve the convergence probability of the transformation matrix solutions.

Characterization and comparison of differentially expressed genes involved in Chlamydia psittaci persistent infection in vitro and in vivo.

Chlamydia psittaci is an obligate intracellular zoonotic pathogen that can enter a persistence state in host cells. While the exact pathogenesis is not well understood, this persistence state may play an important role in chronic Chlamydia disease. Here, we assess the effects of chlamydial persistence state in vitro and in vivo by transmission electron microscopy (TEM) and cDNA microarray assays.

Effects of cadmium stress at different concentrations on the reproductive behaviors of beet armyworm Spodoptera exigua (Hübner).

Insects are exposed to cadmium stress since cadmium pollution has increasingly become a serious global environmental issue. However, until now few studies have paid attention to the effect of heavy metals on insect reproductive behaviors. In our study, the courtship behaviors, mating behaviors and fecundity of beet armyworm Spodoptera exigua (Lepidoptera: Noctuidae) exposed to different concentrations of cadmium in artificial diets at larval stage were studied.

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas.

A dysfunctional immune response in coronavirus disease 2019 (COVID-19) patients is a recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent immune cells is not complete. We applied single-cell RNA sequencing to 284 samples from 196 COVID-19 patients and controls and created a comprehensive immune landscape with 1.46 million cells.

Deciphering the Link Between Mental Health and Green Space in Shenzhen, China: The Mediating Impact of Residents' Satisfaction.

Rapid urbanization and increasing urban density in China threaten residents' mental health. As a vital component of built environments, green space plays a key role in individuals' psychological well-being; however, the mediating effect of residents' satisfaction with the green space environment on the relationship between urban greening and residents' mental health in Chinese contexts has yet to be thoroughly explored. To fill this knowledge gap, this paper attempts to reveal the internal logic and mechanism underlying the linkages between green space, residents' mental health, and their satisfaction with green space in Shenzhen, China.