Publications by authors named "Yuqin Zeng"

Background: Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous condition with different risk factors, including family history. This study aimed to explore association between a family history of chronic airway disease and features and outcomes of COPD.

Methods: Participants were obtained from the RealDTC study between December 2016 and December 2022.

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Background: The influenza vaccination rate of chronic obstructive pulmonary disease (COPD) patients in China was very low. In this study, we aimed to evaluate the effect of clinician-led intensive health education on influenza vaccination in outpatients with COPD and the effect of influenza vaccination on the risk of acute exacerbations in the real world.

Methods: Participants were from the Real World Research of Diagnosis and Treatment of COPD study, a real-world prospective cohort study.

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Background: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 revised the combined chronic obstructive pulmonary disease (COPD) assessment, merging groups C and D into group E, and revised the initial inhalation therapy recommendation. We aimed to evaluate the treatment responses among different inhalation therapies in GOLD group E patients stratified by the COPD assessment test (CAT) scores and forced expiratory volume in one-second percentage of predicted (FEV1%pred).

Methods: In this retrospective cohort study, we included patients with COPD registered in the Real World Research of Diagnosis and Treatment of COPD (RealDTC) study between January 2017 and June 2023.

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Background: Bone marrow mesenchymal stem cells (BMSCs)-derived exosomes are rich in a variety of active substances, including microRNA (miR) and have shown powerful therapeutic effects to ameliorate cell injury and diseases. However, the role of BMSCs-derived exosomes on chronic obstructive pulmonary disease (COPD) has been poorly studied. In addition, pulmonary microvascular endothelial cells (PMVECs) apoptosis contributes to the onset of COPD.

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Bacterial meningitis is a severe and life-threatening infection of the central nervous system (CNS), primarily caused by and . This condition carries a high risk of mortality and severe neurological sequelae, such as cognitive impairment and epilepsy. Pain, a central feature of meningitis, results from the activation of nociceptor sensory neurons by inflammatory mediators or bacterial toxins.

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Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a significant global public health issue with high mortality rates and challenges posed by drug-resistant strains, emphasizing the continued need for new therapeutic targets and effective treatment strategies. Transcriptomics is a highly effective tool for the development of novel anti-tuberculosis drugs. However, most studies focus only on changes in gene expression levels at specific time points.

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Article Synopsis
  • The study explored how past exacerbation history affects future exacerbations and mortality in COPD patients categorized by the GOLD A and B classifications.
  • Data was collected from 8318 COPD patients in China between 2017 and 2022, tracking their health outcomes until December 2023 or death, focusing on exacerbation events and mortality rates.
  • Results showed that patients in the GOLD E group had the highest risk of future exacerbations and mortality, while those in GOLD A1 experienced significantly increased risks compared to GOLD A0; specific inhaled corticosteroids were found to be beneficial in reducing exacerbation risks in certain groups.
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  • The study aimed to evaluate how well the Clinical COPD Questionnaire (CCQ) and its subdomains can predict hospitalized exacerbations in COPD patients over a 3-year period.
  • Results indicated that the total CCQ score and its functional and symptom subdomains were significantly linked to these exacerbations, while the mental subdomain did not show a significant association.
  • Notably, the functional domain demonstrated a predictive capacity equal to that of the total CCQ and was superior to the symptom and mental subdomains, enhancing the effectiveness of other predictive models when included.
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  • The study aimed to determine the safety and effectiveness of early comprehensive pulmonary rehabilitation for patients hospitalized with acute exacerbations of chronic obstructive pulmonary disease (COPD).
  • Involving 108 patients, the research measured outcomes like walking distance, quality of life, breathlessness, and muscle strength, finding significant improvements in walking distance and inspiratory muscle strength for those receiving rehabilitation compared to usual care.
  • The results suggest that early pulmonary rehabilitation is both safe and beneficial, offering noticeable improvements in patient outcomes and being recommended to start during the early stages of hospitalization.
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Tuberculosis (TB) is a chronic disease caused by Mycobacterium tuberculosis (M.tb) and responsible for millions of deaths worldwide each year. It has a complex pathogenesis that primarily affects the lungs but can also impact systemic organs.

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Mycobacterium tuberculosis (Mtb) is an intracellular pathogen capable of adapting and surviving within macrophages, utilizing host nutrients for its growth and replication. Cholesterol is the main carbon source during the infection process of Mtb. Cholesterol metabolism in macrophages is tightly associated with cell functions such as phagocytosis of pathogens, antigen presentation, inflammatory responses, and tissue repair.

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Considering the widespread use of COVID-19 vaccines as a preventive measure against the spread of the virus, it's necessary to direct attention to the adverse effects associated with vaccines in a limited group of populations. Multiple evanescent white dot syndrome (MEWDS) following COVID-19 vaccination is a rare adverse reaction associated with COVID-19 vaccines. In this systematic review, we collected 19 articles with 27 patients up to November 1, 2023, summarizing the basic information, clinical manifestations, examinations, treatments, and recoveries of the 27 patients.

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Article Synopsis
  • Cigarette smoking significantly contributes to COPD and can lead to the death of pulmonary microvascular endothelial cells (PMVECs), with LRG1 playing a pivotal role in this process.
  • In a study involving both human subjects and a mouse model of emphysema, increased levels of LRG1 and KLK10 were found in the lungs of COPD patients and in animals exposed to cigarette smoke.
  • The research concluded that LRG1 promotes apoptosis in PMVECs by up-regulating KLK10, which in turn decreases the survival proteins Bcl-2 and Bax, highlighting a potential pathway for targeted therapies in COPD.
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Background: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. There is no nomogram model available for mortality prediction of stable COPD. We intended to develop and validate a nomogram model to predict mortality risk in stable COPD patients for personalised prognostic assessment.

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The central nervous system (CNS) harbors its own special immune system composed of microglia in the parenchyma, CNS-associated macrophages (CAMs), dendritic cells, monocytes, and the barrier systems within the brain. Recently, advances in the immune cells in the CNS provided new insights to understand the development of tuberculous meningitis (TBM), which is the predominant form of () infection in the CNS and accompanied with high mortality and disability. The development of the CNS requires the protection of immune cells, including macrophages and microglia, during embryogenesis to ensure the accurate development of the CNS and immune response following pathogenic invasion.

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  • Cough is a prevalent symptom in COPD patients, affecting their clinical characteristics and treatment outcomes depending on the inhaled therapies they receive.
  • The study analyzed 906 patients, determining that 64.1% reported frequent cough, which was linked to being a current smoker and worse CAT scores.
  • Results showed that while 62% of frequent cough patients improved after treatment, those on LABA/LAMA or ICS/LABA/LAMA therapy had better outcomes, experiencing fewer exacerbations and achieving clinically significant improvements.
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  • The study investigates the link between education levels and the clinical characteristics and outcomes of chronic obstructive pulmonary disease (COPD) in China, noting that many COPD patients have low education.
  • Analysis of data from over 4,000 COPD patients shows that those with low education faced worse symptoms, more frequent exacerbations, and a higher mortality rate.
  • The findings highlight the importance for healthcare providers to pay special attention to low-education COPD patients due to their increased health risks and poorer outcomes.
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Background: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 report revised the combined assessment, merged the C and D groups into the E group, and revised the initial inhalation therapy recommendation.

Objectives: This study aimed to analyze the future exacerbation and mortality of different inhalation therapies among patients with chronic obstructive pulmonary disease (COPD) in various groups based on the GOLD 2017 and GOLD 2023 reports.

Design: This is a multicenter and retrospective study.

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Background: The revised Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 group ABE classification has undergone major modifications, which can simplify clinical assessment and optimize treatment recommendations for Chronic Obstructive Pulmonary Disease (COPD). However, the predictive value of the new grouping classification for prognosis is worth further exploration. We aimed to compare the prediction of hospitalization and mortality between this new GOLD group 2023 ABE classification and the earlier 2017 ABCD classification in a Chinese COPD cohort.

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Background: We analyzed the clinical characteristics and outcomes in non-frequent exacerbation patients with chronic obstructive pulmonary disease (COPD).

Methods: In this retrospective cohort study, we enrolled patients with stable COPD from 12 hospitals. Non-frequent exacerbation was defined as less than two times of exacerbations in the past year.

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This study aimed to analyze the clinical characteristics and treatment response of patients with chronic obstructive pulmonary disease (COPD) with low body mass index (BMI). In this cross-sectional study, we enrolled patients with stable COPD from the database setup by the Second Xiangya Hospital of Central South University. We classified the patients into three groups based on BMI: low-BMI (<18.

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This study sought to compare treatment persistence, adherence, and risk of exacerbation among patients with COPD treated with single-inhaler triple therapy (SITT) and multiple-inhaler triple therapy (MITT) in the Chinese population. This was a multicenter, prospective observational study. Patients with COPD from ten hospitals in Hunan and Guangxi provinces in China were recruited from 1 January 2020 to 31 November 2021 for the study and were followed up for one year.

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Purpose: Study the impact of impaired sleep quality on symptom change and future exacerbation of chronic obstructive pulmonary disease (COPD) patients.

Methods: This was a prospective study. Patients with COPD were recruited into the study and followed up for one year.

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Background: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) document suggests that patients with chronic obstructive pulmonary disease (COPD) should be divided into a less symptomatic group. Moreover, single-inhaled drugs are recommended as initial inhalation therapy for them. However, many less symptomatic patients are provided double or triple-inhaled drugs as initial therapy in the real world.

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Article Synopsis
  • This study analyzed the clinical characteristics, exacerbation risk, and mortality among chronic obstructive pulmonary disease (COPD) patients classified as more symptomatic, based on the GOLD 2017 guidelines.
  • The retrospective cohort included 1,729 stable COPD patients, followed for 18 months, with findings showing that more symptomatic patients experienced greater age, higher COPD assessment scores, and increased hospitalization rates.
  • Key risk factors identified for mortality included age over 65 and high COPD assessment test scores, while current smoking and previous exacerbations were linked to higher likelihood of future exacerbations.
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