Publications by authors named "Yuqin Wang"

Background: Long-term, potentially lifelong therapy is needed to treat noninfectious uveitis (NIU) in children. Previous research has focused primarily on treatment approaches, but few studies have investigated the effect of children's chronic illness on other family members. The aim of this study is to explore the experiences of burden and needs in caregivers of children with NIU, and to provide a reference for formulating targeted intervention strategies.

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In the western Henan agricultural area, Duhu (Dupo♂ × Hu sheep♀) hybrid lambs are the primary breed of local meat sheep, predominantly raised in large-scale indoor feeding systems, although many farmers still rely on grazing. However, limited research exists on the meat quality of Duhu lambs under both grazing and indoor feeding systems. This study examined how grazing and indoor feeding affect the nutritional quality, flavor, amino acid profile, and fatty acid composition of 7-month-old Duhu lamb meat.

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Acetic acid bacteria (AAB) play a pivotal role in the food fermentation industry, especially in vinegar production, due to their ability to partially oxidize alcohols to acetic acid. However, economic bioproduction using AAB is challenged by harsh environments during acetic acid fermentation, among which initial ethanol pressure, subsequent acetic acid pressure, and consistently high temperatures are common experiences. Understanding the stress-responsive mechanisms is essential to developing robust AAB strains.

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Hyaluronic acid (HA) nanogels have attracted widespread attention, aiming to improve cancer treatment paradigms and overcome the limitations of free-form drugs. However highly hydrophilic nature of HA nanogels limits their potential application where amphiphilic interactions are required for the delivery of hydrophobic drugs. In this study, we developed amphiphilic structure oxaliplatin (OXA) loaded oligo-hyaluronic acid (oHA)-PEG-Octane nanogel using stable disulfide bonds with ultrasonic re-emulsion method.

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Under the current context of intensive farming, small-horned animals are more suitable for large-scale breeding. The CASP14 gene, closely associated with skin and keratin formation, may influence horn size due to its link with skin development. This study comprehensively analyzed the tissue-specific expression of CASP14 using RNA-Seq data, identified functional sites through whole-genome sequencing (WGS), and investigated allele-specific expression (ASE) validated by KASP assays.

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Article Synopsis
  • The study focused on the expression of miRNA-375 in the hypothalamic-pituitary-gonadal axis of female Hu sheep, involving cloning its precursor sequence and comparing it to data in various species.
  • It used real-time PCR to measure the levels of miR-375 in various tissues, finding that its expression was highest in the pineal gland compared to other reproductive and brain tissues.
  • The research identified that miR-375 is connected to multiple biological processes and pathways, particularly the Hippo and Wnt pathways, suggesting it plays a key role in regulating sheep reproduction.
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Background: To evaluate contrast sensitivity function (CSF) in convalescent Vogt-Koyanagi-Harada (VKH) disease and investigate the relationship between CSF and chorioretinal thickness in VKH patients with and without sunset glow fundus (SGF).

Methods: This is a cross-sectional study. Seventy-six eyes of VKH patients and 56 eyes of normal controls were evaluated.

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  • Primary liver cancer, particularly hepatocellular carcinoma (HCC), is common globally but has a poor prognosis despite available treatments, highlighting the need for better population identification.
  • This study aimed to evaluate the effectiveness of lenvatinib combined with camrelizumab for HBV-related HCC patients at BCLC stages B/C, exploring the impact of various BMI categories.
  • Results indicated that overweight and obese patients experienced significantly longer progression-free and overall survival compared to non-overweight patients, although fatigue was more common in the overweight/obese group.
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Aluminum-air battery has the advantages of high energy density, low cost and environmental protection, and is considered as an ideal next-generation energy storage conversion system. However, the slow oxygen reduction reaction (ORR) in air cathode leads to its unsatisfactory performance. Here, we report an electrode made of N and Ni co-doped MnO nanotubes.

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Background: Arabinoxylan is commonly used as a hydrocolloid in frozen dough to improve the texture and the sensory qualities of the products. The effects of vinegar residue arabinoxylan (VRAX) on the secondary structures and microstructures of gluten proteins during freeze-thaw storage were studied, and the underlying mechanism governing these effects was clarified.

Results: The results revealed that VRAX improved the textural properties of gluten proteins, but had a negative impact on their viscoelasticity.

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Microneedle technologies have emerged as a promising transdermal drug delivery platform for postoperative tumor therapy. Despite their potential, enhancing intracellular drug delivery to tumor cells and boosting the therapeutic efficiency of microneedles pose significant challenges. Herein, we develop a nanomedicine-loaded microneedle to enhance the induction of ferroptosis and immunogenic cell death for postoperative tumor therapy.

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The economic and reasonable design of highly stable and corrosion-resistant electrodes is fundamental to achieving the industrial-scale hydrogen productions via water electrolysis, but electrodes' premature failures are often caused by corrosion and stress damage. Therefore, these challenges are successfully solved by utilizing conductive and crack-resistant polyaniline "stabilizer" with a mild chemical plating process to construct the catalytic electrode on a titanium substrate (15 %PANI-NiB@Ti) in the present work. The 15 %PANI-NiB@Ti catalytic electrodes have been in continuous operation for 350 h at the current density of 200 mA cm with the high efficiency of 98.

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The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing, affecting up to 30% of the population, with approximately 20% of cases occurring in non-obese individuals. The recent shift to the term metabolic dysfunction-associated steatosis liver disease (MASLD) highlights the disease's heterogeneity. However, there are no well-established animal models replicating non-obese NAFLD (NO-NAFLD).

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Article Synopsis
  • Transition metal-catalyzed C-H annulation reactions have been commonly used to synthesize N-protected cinnolines, but previously, cinnolin-4(1)-ones remained unattainable.
  • The study introduces a new method for creating cinnolin-4(1)-ones using Rh(III) or Ru(II) catalysts combined with a sequence of reactions involving cyclic hydrazides and vinylene carbonate.
  • The research also highlights the significance of π-conjugation in the directing groups and provides detailed mechanistic insights through the characterization of a seven-membered enolic Rh species using mass spectroscopy.
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  • Glomus tumors (GT) are special growths that come from a type of tissue in the body.
  • Most of these tumors appear in soft parts of the body like arms and legs, but they can show up anywhere.
  • This text talks about a rare case of a glomus tumor found in the prostate, which is unusual.
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TRIM44, a tripartite motif (TRIM) family member, is pivotal in linking the ubiquitin-proteasome system (UPS) to autophagy in multiple myeloma (MM). However, its prognostic impact and therapeutic potential remain underexplored. Here, we report that TRIM44 overexpression is associated with poor prognosis in a Multiple Myeloma Research Foundation (MMRF) cohort of 858 patients, persisting across primary and recurrent MM cases.

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Background: Cardiac hypertrophy and its associated remodeling are among the leading causes of heart failure. Lysine crotonylation is a recently discovered posttranslational modification whose role in cardiac hypertrophy remains largely unknown. NAE1 (NEDD8 [neural precursor cell expressed developmentally downregulated protein 8]-activating enzyme E1 regulatory subunit) is mainly involved in the neddylation modification of protein targets.

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  • * Advanced techniques like HS-SPME-GC-MS, HPLC, and high-throughput sequencing were used to analyze how these factors influenced flavor and microbial communities.
  • * The results indicated that ZAV made in autumn had the best flavor and revealed that factors like room temperature and humidity significantly influenced the fermentation process, aiding in improving vinegar quality.
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RNA methylation has emerged as a dynamic regulatory mechanism that impacts gene expression and protein synthesis. Among the known RNA methylation modifications, N6-methyladenosine (mA), 5-methylcytosine (mC), 3-methylcytosine (mC), and N7-methylguanosine (mG) have been studied extensively. In particular, mA is the most abundant RNA modification and has attracted significant attention due to its potential effect on multiple biological processes.

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  • - TRIM44 is a deubiquitinase that connects the stress response to autophagy, which is important for understanding cancer and neurological diseases.
  • - The study shows that TRIM44 enhances autophagy under oxidative stress, helping cancer cells survive treatments like arsenic trioxide by affecting key proteins involved in this process.
  • - TRIM44's role in promoting SQSTM1 oligomerization and its phosphorylation boosts the oxidative stress response, indicating its potential impact on diseases related to aging and neurodegeneration.
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Urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) is regarded as a biomarker for β-amyloid protein deposition in Alzheimer disease (AD). The value of AD7c-NTP in predicting post-stroke cognitive recovery was worth exploring. In total, 224 patients with first-ever stroke were enrolled in this retrospective study.

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  • Acute retinal necrosis (ARN) is a serious eye condition caused by herpesvirus infections and can lead to significant vision loss if not diagnosed and treated quickly.
  • Researchers developed a deep learning model called DeepDrARN that uses ultra-widefield color fundus photography to effectively differentiate ARN from other forms of uveitis, utilizing a dataset of over 11,500 images.
  • DeepDrARN showed impressive performance, achieving high accuracy in identifying uveitis types and outperformed average ophthalmologists, suggesting it could be a valuable tool for timely diagnosis.
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Synopsis of recent research by authors named "Yuqin Wang"

  • - YuQin Wang's recent research encompasses a diverse range of fields, including cancer therapy, energy conversion, and food science, highlighting a multidisciplinary focus on improving health outcomes and sustainable technologies
  • - Key findings include the evaluation of body mass index as a factor in the prognosis of hepatocellular carcinoma immunotherapy, the development of novel catalysts for aluminum-air batteries, and the enhancement of gluten protein properties through arabinoxylan treatments
  • - Wang's work also explores innovative methodologies such as microneedle technology for cancer treatment, the creation of antioxidant-enhanced curcumin nanoparticles, and establishing a new animal model for understanding nonalcoholic fatty liver disease in non-obese patients