Publications by authors named "Yuqiang Lu"
Article Synopsis
- A study was conducted in 16 towns in China to assess the impact of screening for nasopharyngeal carcinoma (NPC) on mortality rates, comparing a screening group to a control group without intervention.
- Residents aged 30-69 participated in serum tests for Epstein-Barr virus (EBV) antibodies, and follow-ups were conducted up to December 2019.
- Results showed a significant 30% reduction in NPC-specific mortality in the screening group, particularly in participants aged 50 and older, indicating that NPC screening can improve survival outcomes.
Article Synopsis
- * The case study describes a 41-year-old man whose initial symptoms included severe hiccups and vomiting, later developing fever, headache, and muscle weakness, which led to the discovery of extensive transverse myelitis via MRI.
- * Although initially thought to have infectious meningomyelitis, the patient's distinct cerebrospinal fluid findings ultimately confirmed an NMOSD diagnosis, emphasizing the importance of the AQP4 antibody test for accurate and timely treatment.
Epstein-Barr virus (EBV) is one of the risk factors of nasopharyngeal carcinoma (NPC), and understanding the modifiable risk factors of EBV activation is crucial in the prevention of NPC. In this study, we aimed to investigate the association between solid fuel use and EBV seropositivity in a high-risk area of NPC. Our study was based on the baseline findings from an ongoing population-based prospective cohort in Sihui county in Southern China.
View Article and Find Full Text PDFArticle Synopsis
- The study examined the link between herbal soup and tea consumption and the risk of developing nasopharyngeal carcinoma (NPC) in southern China.
- Over a follow-up period of about 7.5 years involving 10,179 participants, it was found that higher consumption of herbal soup significantly reduced NPC risk, while herbal tea showed no notable effect.
- Additionally, herbal soup was linked to lower levels of Epstein-Barr virus (EBV) antibodies among participants, suggesting that it may help inhibit EBV reactivation, which is associated with NPC.
Background: Although stratifying individuals with respect to nasopharyngeal carcinoma (NPC) risk with Epstein-Barr virus-based markers is possible, the performance of diagnostic methods for detecting lesions among screen-positive individuals is poorly understood.
Methods: The authors prospectively evaluated 882 participants aged 30 to 70 years who were enrolled between October 2014 and November 2018 in an ongoing, population-based NPC screening program and had an elevated NPC risk. Participants were offered endoscopy and magnetic resonance imaging (MRI), and lesions were identified either by biopsy at a follow-up endoscopy or further contact and linkage to the local cancer registry through December 31, 2019.
Article Synopsis
- The study aimed to validate an Epstein-Barr virus (EBV)-based risk score for nasopharyngeal carcinoma (NPC) in a high-risk population in southern China, where a screening trial has been in place since 2008 involving over 51,000 adults.
- The EBV score demonstrated high discriminatory ability with an area under the receiver-operator-characteristics curve (AUC) of 0.95, achieving 87.4% sensitivity at 90% specificity while showing that adding other risk factors like sex and family history did not enhance predictive power.
- The highest absolute risk of NPC was found in men aged 55 to 59 years with the most elevated risk profile, indicating
Dysfunction of long noncoding RNA (lncRNA) is associated with tumorigenesis of various malignancies, including glioma. Previously, lncRNA ARRDC1 antisense RNA 1(ARRDC1-AS1) has been reported to be dysregulated in several tumors. However, the roles of ARRDC1-AS1 in glioma have not been investigated.
View Article and Find Full Text PDFIntroduction: This study investigated the influence of lockdown during the 2019 coronavirus disease (COVID-19) pandemic on the quality of life of patients with Parkinson's disease (PD).
Methods: We conducted a questionnaire survey involving 113 patients with PD from Xihu District, Hangzhou, Zhejiang. During the epidemic prevention and control period (February 1 to March 31, 2020), patients enrolled were asked to fill out questionnaires, including the "COVID-19 Questionnaire for PD Patients during the Period of Epidemic Prevention and Control" and "39-item Parkinson's Disease Questionnaire (PDQ-39).
Background: The association between smoking and nasopharyngeal carcinoma (NPC) is still uncertain. The aim of this study was to validate smoking effect on NPC and explore if smoking can induce NPC by persistently reactivating EBV in long-term based on a prospective cohort design.
Methods: A NPC screening cohort with 10 181 eligible residents in Sihui city, southern China was conducted from 2008 to 2015.
Background: The association of circulating inflammation markers with nasopharyngeal carcinoma (NPC) is still largely unclear. This study aimed to comprehensively explore the relationship between circulating cytokine levels and the subsequent risk of NPC with a two-stage epidemiologic study in southern China.
Methods: The serum levels of 33 inflammatory cytokines were first measured in a hospital-based case-control study (150 NPC patients and 150 controls) using multiplex assay platforms.
Autophagy alterations have been observed in a variety of neurological disorders, however, very few studies have focused on autophagy alterations in epilepsy. The ketogenic diet (KD) likely ameliorates neuronal loss in several seizure models. However, whether this neuroprotective function occurs via starvation-induced autophagy and its prevalence in chronic kindled seizures remains unknown.
View Article and Find Full Text PDFBackground: Southern China is an endemic area for primary liver cancer (PLC), but it is unclear if rates have changed in recent decades. We evaluated PLC incidence and estimated the effects of age, period of diagnosis, and birth cohort in Sihui City, Guangdong Province, China.
Methods: Age-standardized rates (ASRs) of PLC were examined for both males and females from 1987 to 2011.
The ketogenic diet (KD) controls seizure and improves cognition in patients with drug refractory epilepsy. However, few experimental models have shown this neuroprotective effect on cognition. In this study, we investigated the cognitive protective effects of KD in pentylenetetrazol (PTZ)-kindled rats.
View Article and Find Full Text PDFAccelerating simultaneous algebraic reconstruction technique with motion compensation using CUDA-enabled GPU.
Int J Comput Assist Radiol Surg
March 2011
Purpose: To accelerate the simultaneous algebraic reconstruction technique (SART) with motion compensation for speedy and quality computed tomography reconstruction by exploiting CUDA-enabled GPU.
Methods: Two core techniques are proposed to fit SART into the CUDA architecture: (1) a ray-driven projection along with hardware trilinear interpolation, and (2) a voxel-driven back-projection that can avoid redundant computation by combining CUDA shared memory. We utilize the independence of each ray and voxel on both techniques to design CUDA kernel to represent a ray in the projection and a voxel in the back-projection respectively.