Alveolar-arterial partial pressure difference as an early predictor for patients with acute paraquat poisoning.

Objective: Paraquat (PQ) is associated with high mortality rates in acute poisoning. This study aimed to determine the importance of the alveolar-arterial partial pressure difference (A-aDo) in the expected consequences of acute PQ poisoning.

Methods: Patients who were hospitalized for PQ poisoning in 2018 were enrolled in this retrospective study.

The novel camptothecin derivative, CPT211, induces cell cycle arrest and apoptosis in models of human breast cancer.

Objective: Breast cancer is the second leading cause of cancer deaths in women worldwide and represents a highly aggressive nature with limited therapeutic options; thus, investigating novel therapeutic agents for breast cancer is much needed. In this study, we investigated the anticancer effects of a novel camptothecin derivative, CPT211, against human breast cancer.

Methods: We used hormone receptor-positive MCF-7, triple-negative (TNBC) MDA-MB-231, and HER2-positive BT-474 human breast cancer cells to examine cytotoxicity of CPT211.

[Short-term efficacy and factors of specific immunotherapy on patients with allergic rhinitis].

Objective: To evaluate the short-term efficacy and investigate the factors of specific immunotherapy (SIT) efficacy of allergic rhinitis.

Method: Fifty-seven patients with allergic rhinitis to dermatophagoides pteronysinus were included to receive SIT. Pair t-test was used to compare the symptom scores, visual analogue scores (VAS) and medication scores in patients before SIT and into maintain treatment statement to evaluate the clinical efficacy.

[Research on the association of the laryngeal carcinoma and laryngopharyngeal reflux].

Objective: The objective of this study is to investigate the association between laryngeal carcinoma and laryngopharyngeal reflux.

Methods: This was a case-control study with 31 laryngeal cancer patients who had undergone 24-hour ambulatory double pH monitoring and 76 in the control group which were divided into negative group (36 patients) and positive group (40 patients) by the score of RSI (reflux symptom index) and RFI (reflux findings index) scale. The results of reflux and parameters of 24-hour ambulatory double pH monitoring among the three groups were statistically analysed.