miR-455-3p enhances chondrocytes apoptosis and inflammation by targeting COL2A1 in the osteoarthritis model.

Emerging evidence has shown that microRNAs are important regulators in osteoarthritis (OA). Here, we investigated the function role of miR-455-3p in the pathogenesis of OA and the underlying molecular mechanisms. We first established the OA model using IL-1β treated human chondrocyte cell line CHON-001.