Effects of prolonged NaHCO exposure on the serum immune function, antioxidant capacity, intestinal tight junctions, microbiota, mitochondria, and autophagy in crucian carp (Carassius auratus).

This study investigated the effects of long-term NaHCO stress on serum immunity, antioxidant capacity, intestinal tight junction, intestinal microbiota, mitochondrial function and autophagy in crucian carp. A total of 240 fish (31.19 ± 1.

Positive association between constipation and mild cognitive impairment in elders: A cross-sectional study.

This study aimed to examine the association between constipation and mild cognitive impairment (MCI); and further elucidate the possible mechanisms involved. A cross-sectional study was conducted among community-dwelling elders (N = 789) in Nanning, China. Trained research staffs collected detailed information through questionnaires and physical examinations.

α-lipoic acid ameliorates hepatotoxicity induced by chronic ammonia toxicity in crucian carp (Carassius auratus gibelio) by alleviating oxidative stress, inflammation and inhibiting ERS pathway.

High environment ammonia (HEA) poses a deadly threat to aquatic animals and indirectly impacts human healthy life, while nutritional regulation can alleviate chronic ammonia toxicity. α-lipoic acid exhibits antioxidative effects in both aqueous and lipid environments, mitigating cellular and tissue damage caused by oxidative stress by aiding in the neutralization of free radicals (reactive oxygen species). Hence, investigating its potential as an effective antioxidant and its protective mechanisms against chronic ammonia stress in crucian carp is highly valuable.

Control of phosphorus release from sediment by hydrous zirconium oxide combined with calcite, bentonite and zeolite.

This study investigated the effectiveness and mechanism for the control of internal phosphorus (P) liberation from sediment by hydrous zirconium oxide (HZrO) combined with calcite, bentonite and zeolite. The results suggested that coexisting calcite, calcium-modified bentonite (CaBT) and calcium-modified zeolite (CaZ) all had the ability to promote the adsorption of phosphate (PO) onto HZrO. The mechanisms of PO elimination by HZrO/calcite mixture involved the adsorption of PO on calcite, the precipitation of PO with Ca, and the inner-sphere complexation of PO with HZrO.

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.

Phase transitions of cellular proteins and lipids play a key role in governing the organisation and coordination of intracellular biology. The frequent juxtaposition of proteinaceous biomolecular condensates to cellular membranes raises the intriguing prospect that phase transitions in proteins and lipids could be co-regulated. Here we investigate this possibility in the ribonucleoprotein (RNP) granule-ANXA11-lysosome ensemble, where ANXA11 tethers RNP granule condensates to lysosomal membranes to enable their co-trafficking.

A formal [4 + 2] annulation of diamines and prop-2-ynyl sulfonium salts for the synthesis of tetrahydroquinoxalines.

A formal [4 + 2] annulation of diamines and prop-2-ynyl sulfonium salts was developed. This strategy enables efficient access to tetrahydroquinoxalines in excellent yields.

Lean Design of the Pediatric Intensive Care Unit Patient Room for Efficient and Safe Care Delivery.

Background: The pediatric intensive care unit (PICU) is an environment where seriously ill children receive complex care, delivered mostly by specialty-trained nurses (registered nurses [RNs]) who must perform multiple high-level tasks. With stressors on healthcare systems at an all-time high, design that optimizes RN workflow has taken on a renewed imperative.

Objectives: To employ a multimodal approach (1) to identify environmental factors in the PICU patient room that contribute to caregiver workflow inefficiencies, (2) to optimize safety by identifying high-touch surfaces that cause hospital-acquired infections, (3) to develop human-centered design recommendations.

A digital twin-driven human-robot collaborative assembly approach in the wake of COVID-19.

In the wake of COVID-19, the production demand of medical equipment is increasing rapidly. This type of products is mainly assembled by hand or fixed program with complex and flexible structure. However, the low efficiency and adaptability in current assembly mode are unable to meet the assembly requirements.

Effect of dissolved oxygen on nitrogen removal and the microbial community of the completely autotrophic nitrogen removal over nitrite process in a submerged aerated biological filter.

Dissolved oxygen (DO) is a crucial parameter of the completely autotrophic nitrogen removal over nitrite (CANON) process. This study determined the nitrogen removal performance and microbial community of the CANON process in a laboratory-scale submerged aerated biological filter (SABF) over a DO concentration range from 0 to 1.2 mg·L.

Start-up of the completely autotrophic nitrogen removal over nitrite process with a submerged aerated biological filter and the effect of inorganic carbon on nitrogen removal and microbial activity.

Good start-up and performance are essential for the completely autotrophic nitrogen removal over nitrite (CANON) process, and inorganic carbon (IC) is also important for this process. In this study, a lab-scale submerged aerated biological filter (SABF) was adopted for the CANON process. A 16S rRNA gene high-throughput sequencing analysis showed that the phyla Proteobacteria and Planctomycetes were the dominant microorganisms and that the genus Candidatus Brocadia functioned as the nitrogen remover.

Returns to scale in food preparation and the Deaton-Paxson puzzle.

We consider returns to scale in food preparation as a potential resolution of a puzzle raised by Deaton and Paxson (Journal of Political Economy, (5), 897-930, 1998). We clarify the conditions under which returns to scale in food preparation can resolve the puzzle. The key requirement is that foods are heterogeneous in time costs.

Trends in out-of-pocket health care expenditures in Canada, by household income, 1997 to 2009.

Background: Canadian households are spending an increasing share of their household income on health care not covered by public plans. This study investigates trends in out-of-pocket expenditures for health care services and products by household income quintile from 1997 to 2009.

Data And Methods: Biennial estimates from the Survey of Household Spending between 1997 and 2009 were used to examine changes in out-of-pocket health care expenditures, by household income quintile.