Exploration of ferroptosis-related biomarkers with prognostic capability in RIF based on WGCNA.

Purpose: To explore the association of ferroptosis with repeated implantation failure (RIF) and prognostic capability of ferroptosis-related genes.

Methods: Data in GSE106602 from the GEO database were used for gene co-expression network construction to confirm ferroptosis-related genes compared to gene sets that were downloaded from FerrDB. Then these genes were analyzed for functional enrichment and validated using endometrium samples from our center.

Exosomes derived from hypoxic mesenchymal stem cells restore ovarian function by enhancing angiogenesis.

Background: hucMSC-exosomes can be engineered to strengthen their therapeutic potential, and the present study aimed to explore whether hypoxic preconditioning can enhance the angiogenic potential of hucMSC-exosomes in an experimental model of POF.

Methods: Primary hucMSCs and ROMECs were isolated from fresh tissue samples and assessed through a series of experiments. Exosomes were isolated from hucMSCs under normoxic or hypoxic conditions (norm-Exos and hypo-Exos, respectively) and then characterized using classic experimental methods.

Optimization of SHP2 allosteric inhibitors with novel tail heterocycles and their potential as antitumor therapeutics.

SHP2, a non-receptor protein tyrosine phosphatase involved in cancers, plays a pivotal role in numerous cellular signaling cascades, including the MAPK and PD-L1/PD-1 pathways. Although several SHP2 allosteric inhibitors have already entered clinical trials, none have been approved to date. Therefore, the development of new SHP2 allosteric inhibitors with improved efficacy is urgently required.

Cellulose-Based Transparent Edible Antibacterial Oxygen-Barrier Coating for Long-Term Fruit Preservation.

Long-term preservation of fresh fruit and vegetables without a cold chain is a great challenge to food security because fruits and vegetables are highly vulnerable to poor storage conditions. Fruit spoilage is a complex biochemical process that involves many factors, including microbial reproduction, oxidation, metabolism, and HO evaporation. Only the synergy of the multiple spoilage inhibition methods can achieve long-term freshness preservation.

The triglyceride glucose: high-density lipoprotein cholesterol ratio is associated with coronary artery calcification evaluated via non-gated chest CT.

Background: Coronary artery calcification (CAC) is a common risk factor of cardiovascular disease. Although triglyceride glucose (TYG) index and high-density lipoprotein cholesterol (HDL-c) are both associated with CAC, no study has evaluated the correlation between the TYG/HDL-c ratio and CAC. In the present study, we investigated the relationships between CAC and the TYG index and the TYG/HDL-c ratio.

Mechanism study of ubiquitination in T cell development and autoimmune disease.

T cells play critical role in multiple immune processes including antigen response, tumor immunity, inflammation, self-tolerance maintenance and autoimmune diseases et. Fetal liver or bone marrow-derived thymus-seeding progenitors (TSPs) settle in thymus and undergo T cell-lineage commitment, proliferation, T cell receptor (TCR) rearrangement, and thymic selections driven by microenvironment composed of thymic epithelial cells (TEC), dendritic cells (DC), macrophage and B cells, thus generating T cells with diverse TCR repertoire immunocompetent but not self-reactive. Additionally, some self-reactive thymocytes give rise to Treg with the help of TEC and DC, serving for immune tolerance.

Peroxymonosulfate activation by walnut shell activated carbon supported nano zero-valent iron for the degradation of tetracycline: Performance, degradation pathway and mechanism.

In this study, activated carbon (WS-AC) was prepared from walnut shell. Nano-zero-valent iron (nZVI) was loaded on walnut shell activated carbon by liquid phase reduction method and used as catalyst (WS-AC/nZVI) to activate peroxymonosulfate (PMS) to efficiently degrade tetracycline (TC) in solution. The composite material with a mass ratio of WS-AC to nZVI of 1:1 has the highest catalytic performance for activating PMS to degrade TC.

Bio-clogging mitigation in constructed wetland using microbial fuel cells with novel hybrid air-photocathode.

Excessive accumulation of extracellular polymeric substances (EPS) in constructed wetland (CW) substrate can lead to bio-clogging and affect the long-term stable operation of CW. In this study, a microbial fuel cell (MFC) was coupled with air-photocathode to mitigate CW bio-clogging by enhancing the micro-electric field environment. Because TiO/biochar could catalyze and accelerate oxygen reduction reaction, further promoting the gain of electric energy, the electricity generation of the tandem CW-photocatalytic fuel cell (CW-PFC) reached 90.

Application of an integrated loach-plant-substrate-microbes non-aerated saturated vertical flow constructed wetlands: Mechanisms of pollutants removal and greenhouse gases reduction.

This study established an integrated loach-plant-substrate-microbes non-aerated saturated vertical flow constructed wetlands (VFCWs) to enhance pollutants removal efficiencies and reduce greenhouse gas emissions simultaneously. The results of the VFCWs experiment indicated that the removal efficiencies of chemical oxygen demand, total phosphorous, and total nitrogen in loach systems were significantly higher than those of non-loach systems, achieving 59.16%, 35.

Influence of modified biochar supported sulfidation of nano-zero-valent-iron (S-nZVI/BC) on nitrate removal and greenhouse gas emission in constructed wetland.

In this study, the biochar (BC) produced from sawdust, sludge, reed and walnut were used to support sulfidation of nano-zero-valent-iron (S-nZVI) to enhance nitrate (NO-N) removal and investigate the impact on greenhouse gas emissions. Batch experiment results showed the S-nZVI/BC, S-nZVI/BC, S-nZVI/BC, and S-nZVI/BC respectively improved NO-N removal efficiencies by 22%, 20%, 3% and 0.1%, and the selectivity toward N by 22%, 25%, 22% and 18%.

Exosomes from Human Omental Adipose-Derived Mesenchymal Stem Cells Secreted into Ascites Promote Peritoneal Metastasis of Epithelial Ovarian Cancer.

Epithelial ovarian cancer (EOC) patients frequently develop peritoneal metastasis, especially in the human omentum. However, the mechanism underlying this propensity remains unknown. A previous study found that human omental adipose-derived mesenchymal stem cells are potentially involved in ovarian cancer growth and metastasis, but the results were inconsistent and even contradictory.

Performance and mechanism of azo dyes degradation and greenhouse gases reduction in single-chamber electroactive constructed wetland system.

A single-chamber microbial fuel cell-microbial electrolytic cell with a novel constructed wetland system was proposed for synergistic degradation of congo red and reduction in emissions of greenhouse gases. The closed-circuit system showed higher chemical oxygen demand and congo red removal efficiencies by 98 % and 96 % on average, respectively, than traditional constructed wetland. It could also significantly reduce the emissions of CH and NO (about 52 % CO-equivalents) by increasing the electron transfer.

miR-126-3p containing exosomes derived from human umbilical cord mesenchymal stem cells promote angiogenesis and attenuate ovarian granulosa cell apoptosis in a preclinical rat model of premature ovarian failure.

Background: In our previous research, we found that overexpression of miR-126-3p in human umbilical cord MSCs (hucMSCs) promoted human umbilical vein endothelial cells angiogenic activities through exosome-mediated mechanisms. The present study aimed to investigate the role of miR-126-3p-modified hucMSCs derived exosomes (miR-126-3p-hucMSCs-exosomes) on the treatment of premature ovarian failure (POF).

Methods: Primary hucMSCs were isolated from human umbilical cords and identified by differentiation experiments and flow cytometry.

Adsorption of Hexavalent Chromium by Sodium Alginate Fiber Biochar Loaded with Lanthanum.

Lanthanun oxide (LaO) is a lanthanum chemical compound incorporates a sensible anionic complexing ability; however, it lacks stability at a low pH scale. Biochar fibers will give the benefit of their massive space and plethoric uses on the surface to support a metal chemical compound. Herein, wet spinning technology was used to load La onto sodium alginate fiber, and to convert La into LaO through carbonization.

Enhancement of Cr(VI) removal efficiency via adsorption/photocatalysis synergy using electrospun chitosan/g-CN/TiO nanofibers.

Chitosan/g-CN/TiO (CS/CNT) nanofibers were fabricated by electrospinning technique for Cr(VI) removal through the adsorption and photocatalytic processes. The effects of crucial factors in the adsorption process including contact time (0-1440 min), pH (1-7), initial concentration of Cr(VI) (20-800 mg/L) were investigated. The photocatalytic experiment was executed in a photochemical reactor with an 800 W xenon lamp to simulate visible light.

Prospective study of pregnancy outcome between perceived stress and stress-related hormones.

Aim: To evaluate the relationship between physiological and psychological stress on pregnancy outcome in women undergoing in vitro fertilization-embryo transfer (IVF-ET) treatment.

Methods: Women undergoing the first IVF cycle were enrolled to complete the Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS). Their blood samples were collected on the 3rd day of the menstrual cycle to measure 5-hydroxytryptamine, renin, norepinephrine, angiotensin II and cortisol.

Efficient capture of Cr(VI) by carbon hollow fibers with window-like structure.

Removal of toxic Cr(VI) from contaminated water is significant for environmental protection. High efficient adsorbents with outstanding adsorption performance are highly demanded. Herein, we reported that window-like structured carbon hollow fibers (WL-CHF) derived from Enteromorpha prolifera could capture toxic Cr(VI) from aqueous solutions with high adsorption capacity, fast adsorption rate, and excellent recyclable performance.

Flexible TiO/PVDF/g-CN Nanocomposite with Excellent Light Photocatalytic Performance.

As the world faces water shortage and pollution crises, the development of novel visible light photocatalysts to purify water resources is urgently needed. Over the past decades, most of the reported photocatalysts have been in powder or granular forms, creating separation and recycling difficulties. To overcome these challenges, a flexible and recyclable heterostructured TiO/polyvinylidene fluoride/graphitic carbon nitride (TiO/PVDF/g-CN) composite was developed by combining electrospinning, sintering and hydrothermal methods.

Isorhynchophylline enhances Nrf2 and inhibits MAPK pathway in cardiac hypertrophy.

Isorhynchophylline (IRN) is one of the major tetracyclic oxindole alkaloids found in Uncaria rhynchophylla. Studies have found that IRN has diverse biological activities including antioxidant, anti-apoptosis, and neuroprotection. However, little is known about the effect of IRN on the development of cardiac hypertrophy.

One Step In Situ Loading of CuS Nanoflowers on Anatase TiO/Polyvinylidene Fluoride Fibers and Their Enhanced Photocatalytic and Self-Cleaning Performance.

CuS nanoflowers were loaded on anatase TiO/polyvinylidene fluoride (PVDF) fibers by hydrothermal treated electrospun tetrabutyl orthotitanate (TBOT)/PVDF fibers at low temperature. The results indicated that the amount of copper source and sulfur source determined the crystallization and morphology of the resultant products. It was found that the composite of CuS narrowed the band gap energy of TiO and enhanced the separation efficiency of the photogenerated electron-hole pairs of TiO.

Tamarixetin protects against cardiac hypertrophy via inhibiting NFAT and AKT pathway.

Cardiac hypertrophy is a compensatory response in reaction to mechanical load that reduces wall stress by increasing wall thickness. Chronic hypertrophic remodeling involves cardiac dysfunction that will lead to heart failure and ultimately death. Studies have been carried out on cardiac hypertrophy for years, whereas the mechanisms have not been well defined.

Prognostic value of repeated serum kisspeptin measurements in early first trimester pregnancy: a preliminary study.

Research Question: What is the diagnostic value of maternal kisspeptin in patients with asymptomatic first-trimester pregnancies, and what is the prognostic significance of kisspeptin versus beta-HCG in early pregnancies.

Design: Case-control study in academic medical centres. Patients with no confounding co-morbidities who conceived by IVF and intracytoplasmic sperm injection were analysed.

Inhibition of cardiac hypertrophy by aromadendrin through down-regulating NFAT and MAPKs pathways.

Cardiac hypertrophy is a maladaptive response to pressure overload and it's an important risk factor for heart failure and other adverse cardiovascular events. Aromadendrin (ARO) has remarkable anti-lipid peroxidation efficacy and is a potential therapeutic medicine for the management of diabetes and cardiovascular diseases. In this study, we established the cardiac hypertrophy cell model in rat neonatal ventricular cardiomyocytes (RNVMs) with phenylephrine.