Impacts of hydraulic retention time on organic removal in treating liquor wastewater via algal-bacterial granular sludge.

This study optimized hydraulic retention time (HRT) to improve p-cresol and chemical oxygen demand (COD) removal and promote algal-bacterial granular sludge (ABGS) formation in Chinese fermented liquor wastewater treatment. At an HRT of 4 h, no granules formed in the sequential batch reactor, and after 30 days, the removal efficiencies were low for both COD (58.5 %) and p-cresol (21.

Metabolism profiles of tannins in Phyllanthus emblica L. and its immunotherapeutic potential against hepatocellular carcinoma by re-educating tumor microenvironment.

Purpose: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Tumor-associated macrophages (TAMs) are key components of the immunosuppressive tumor microenvironment and represent significant obstacles to effective immunotherapy. Phyllanthus emblica L.

Ermiao San attenuating Rheumatoid Arthritis via PI3K/AKT/mTOR signaling activate HIF-1α induced glycolysis.

Ethnopharmacological Relevance: As a classic formula, Ermiao San (EMS) characterized by its less medicinal flavor and strong potency had been proven to be effective and safe in the treatment of rheumatoid arthritis (RA) during clinical experience and our previous research.

Aim Of The Study: The therapeutic characteristics of multi-component and multi-target of traditional Chinese medicine prompted us to further investigated the effective compounds of EMS, and evaluated its potential mechanisms in treating RA.

Materials And Methods: Ultra-high-performance liquid chromatography high-resolution mass spectrometry (UPLC-HRMS) was used to analyze the primary absorption components of EMS in rat serum, with secondary mass spectrometry used to assist in identifying the structures of the compounds.

Genome-Wide Identification and Functional Analysis of () in Three Species.

Intercellular communication mediated by CLAVATA3/EMBRYO SURROUNDING REGION-RELATED (CLE) peptides and their receptors is crucial for plant development and environmental adaptation. In this study, 45 and 89 were identified in and × , respectively, and, together with the 52 in , the chromosome localization, gene and protein characteristics, collinearity and gene duplication events, cis-acting regulatory elements in promoters and evolutionary relationships of in these three poplar species were analyzed. The of three poplar species were divided into four subfamilies.

NFAT2 Induces Tumor Cell Proliferation and Metastasis by Acting as a Transcriptional Co-activator of the TGF-β1/SMAD Signaling Pathway and Inducing the Epithelial-Mesenchymal Transition in Liver Cancer.

Background: The role of NFAT2 in liver cancer is conflicting, with evidence suggesting both oncogenic and tumor-suppressive effects. A clear understanding of its expression, function, regulation, and mechanism of action in liver cancer remains critical.

Objectives: To examine the expression levels, biological functions, regulatory mechanisms, and downstream pathways of NFAT2 in liver cancer and its metastasis.

Precise CH Adsorption Affinity Modulation by Nitrogen Functionalization in Isostructural Coordination Networks.

Meticulous regulation of pore chemistry is essential for elucidating the intricate mechanism of the adsorption efficacy of porous materials. However, it is a great challenge to address the functionalization of pore chemistry while preserving pore size and geometry. In this study, the robust NPU-1 series network is selected as a platform to address this challenge.

Physiological and transcriptional reprogramming for salinity tolerance of endangered mangrove associate Hernandia nymphaeifolia.

Background: Hernandia nymphaeifolia is a typical mangrove associate with high ecological, ornamental, and medicinal values, but in China, it has become endangered in recent years, and an urgent protection is needed. Salinity is a key factor for growth and survival of mangrove seedlings, and thus a comprehensive understanding of salt tolerance in mangroves is important for their conservation and afforestation. However, little is known regarding salt-responsive mechanisms in H.

Differential roles of IL-17B and IL-17RB in colorectal cancer: Correlation with immune infiltration and prognosis.

Background: The aim of the research is to investigate correlation of immune infiltration between IL-17B and IL-17RB in colorectal cancer (CRC), then provide an experimental basis for clinical diagnostic marker screening of CRC.

Methods: Gene expression levels were assessed via TIMER and GEPIA databases, protein expression through the Human Protein Atlas (HPA), clinicopathological correlations and prognosis via UALCAN and KM-Plotter, respectively. Mutation analysis was conducted using cBioPortal, immune cell infiltration via TIMER, and hub genes were identified through protein-protein interaction (PPI) networks.

Molecular Insights into the EOR Mechanism of Water, CO, and CO-WAG Flooding in Heterogeneous Nanochannels: A Molecular Dynamic Simulation.

In tight oil exploitation, the water flooding, CO flooding, and CO water gas alternate (CO-WAG) flooding are three commonly adopted methods to enhance the oil recovery (EOR), and the heterogeneous of reservoir has crucial influence on the oil sweep volume and oil displacement efficiency. In this work, molecular dynamic simulation was employed to investigate the displacement behavior in these three flooding methods in the heterogeneous tight reservoir. First, a single nanochannel was used to investigate the different displacement performances in these three flooding methods.

Composite Engineering Facilitates High-Performance CuSe-GeTe Thermoelectrics.

CuSe has emerged as a promising thermoelectric material due to its low lattice thermal conductivity, high Seebeck coefficient, and high peak figure of merit () at elevated temperatures. However, its performance is limited by a high intrinsic carrier concentration and low carrier mobility. In this work, we investigate CuSe-based composites to overcome these challenges by introducing GeTe as compound phase to optimize carrier concentration, enhance mobility, and promote phonon scattering.

Fur-regulated urease contributes to the environmental adaptation of .

Urease converts urea into ammonia and carbon dioxide, providing a nitrogen and carbon source for microbial growth and serving as an important mechanism for human bacterial pathogens to survive in acidic conditions, which can be regulated by many factors. As a global regulator, the ferric uptake regulator (Fur) regulates a series of genes and pathways involved in many different cellular processes and the virulence of the enteric bacterium (). However, whether Fur regulates the urease activity in was still unknown.

Grain Weight and Taste Quality in Rice Are Regulated by Starch Synthesis and Grain Filling Under Nitrogen-Phosphorus Interactions.

To reveal the regulatory effects of nitrogen and phosphorus interactions on grain-filling- and starch-synthesis-related enzymes, and grain weight of superior grains (SGs) and inferior grains (IGs) and taste quality, the rice cultivar Shennong 265 was grown under field conditions with three nitrogen levels (210, 178.5, and 147 kg N ha; N3, N2, and N1) and two phosphorus levels (105 and 73.5 kg P ha; P2 and P1).

Predictive value of the perivascular fat attenuation index for MACE in young people suspected of CAD.

Objective: The perivascular fat attenuation index (FAI) evaluated by coronary computed tomographic angiography (CCTA) has been reported to have strong prognostic value, but few studies have focused on young people. This study aimed to assess the predictive value of the perivascular FAI in young people suspected of having coronary atherosclerotic disease (CAD).

Method: A retrospective analysis was performed on adults aged ≤ 45 years who underwent CCTA due to suspected CAD between 2015 and 2016 and who were followed up for at least 5 years following their visit (n = 503).

Study on the potential diagnostic value of metabolomics changes in different biological fluids for aspiration pneumonia.

Background: Aspiration pneumonia (AP) is a type of lung inflammation caused by the aspiration of food, oropharyngeal secretions, or gastric contents. This condition is particularly common in older adults and individuals with impaired swallowing or consciousness. While the diagnosis of AP relies on clinical history, swallowing assessments, and imaging, these methods have significant limitations, often leading to underdiagnosis or misdiagnosis.

Construction of an Interpretable Model of the Risk of Post-Traumatic Brain Infarction Based on Machine Learning Algorithms: A Retrospective Study.

Background: Post-traumatic cerebral infarction (PTCI) is a severe complication resulting from traumatic brain injury (TBI), which can lead to permanent neurological damage or death. The investigation of the factors associated with PTCI and the establishment of predictive models are crucial for clinical practice.

Methods: We made a retrospective analysis of clinical data from 1484 TBI patients admitted to the Neurosurgery Department of a provincial hospital from January 2018 to December 2023.

Rightward brain structural asymmetry in young children with autism.

To understand the neural mechanism of autism spectrum disorder (ASD) and developmental delay/intellectual disability (DD/ID) that can be associated with ASD, it is important to investigate individuals at an early stage with brain, behavioural and also genetic measures, but such research is still lacking. Here, using the cross-sectional sMRI data of 1030 children under 8 years old, we employed developmental normative models to investigate the atypical development of gray matter volume (GMV) asymmetry in individuals with ASD without DD/ID, ASD with DD/ID and individuals with only DD/ID, and their associations with behavioral and clinical measures and transcription profiles. By extracting the individual deviations of patients from the typical controls with normative models, we found a commonly abnormal pattern of GMV asymmetry across all ASD children: more rightward laterality in the inferior parietal lobe and precentral gyrus, and higher individual variability in the temporal pole.

Diagnostic efficacy of dual-energy CT virtual non-calcium technique in the diagnosis of bone marrow edema of sacroiliac joints in ankylosing spondylitis.

Objective: In-depth investigation of the diagnostic performance of dual-energy CT (DECT) virtual non-calcium (VNCa) technique for sacroiliac joint bone marrow edema (BME) in patients with ankylosing spondylitis(AS).

Methods: A total of 42 patients with AS)who underwent sacroiliac joint MRI and DECT scans on the same day at our Rheumatology and Immunology Department between August 2022 and June 2023 were selected. Using MRI as the reference standard, the presence of BME on the iliac and sacral surfaces was evaluated, resulting in the categorization of patients into BME-positive and BME-negative groups.

Mutation impact on mRNA versus protein expression across human cancers.

Background: Cancer mutations are often assumed to alter proteins, thus promoting tumorigenesis. However, how mutations affect protein expression-in addition to gene expression-has rarely been systematically investigated. This is significant as mRNA and protein levels frequently show only moderate correlation, driven by factors such as translation efficiency and protein degradation.

Stability analysis of an expansive soil slope under heavy rainfall conditions with different anchor reinforcements.

This study investigates the vulnerability of expansive soil slopes to destabilization and damage, particularly under intense rainfall, due to their heightened sensitivity to moisture. Focusing on a project in Yunnan Province, numerical simulation software is employed to address slope stability challenges. Meanwhile, the soil mechanical parameters of this study were acquired through experimentation.

METTL3-mediated m6A modifications of NLRP3 accelerate alveolar bone resorption through enhancing macrophage pyroptosis.

Periodontitis (PD) is twice as prevalent in diabetics compared to nondiabetics, and diabetes-associated PD is characterized by increased inflammation and aggravated tissue damage. Pyroptosis has recently been implicated in diabetes-associated PD; however, the underlying mechanisms remain largely unknown, resulting in a lack of effective treatments. In this study, we investigated the role of methyltransferase-like 3 (METTL3) in macrophage pyroptosis and found that it inhibits the osteogenic differentiation of osteoblasts via pyroptotic macrophages in a diabetes-associated periodontitis mouse model.

Effect of Gonadotropin-Releasing Hormone Agonist Pre-Treatment on Outcomes of Fresh and Frozen Embryo Transfers in Women With Adenomyosis: A Retrospective Cohort Study With Literature Review.

Objectives: To investigate the effect of gonadotropin-releasing hormone agonist (GnRHa) pre-treatment on the clinical outcomes of fresh and frozen embryo transfers (ETs and FETs, respectively) in infertile patients with adenomyosis.

Design: Retrospective cohort study with literature review.

Setting: Peking University First Hospital.

Efficacy and Safety of Stromal Vascular Fraction in the Treatment of Tear Trough Deformity: A Systematic Review and Meta-Analysis.

Background: Stromal vascular fraction (SVF) grafting is an effective method to correct tear trough deformity. Nevertheless, the quantitative data of satisfactory rate and complications of SVF compared with normal autologous fat graft (AFG) remain unemployed. The aim of this meta-analysis was to synthesize the current quantitative data on satisfactory rate and complications of tear trough deformity correction with SVF and normal AFG.

Prognostic value and clinical significance of IL-33 expression in patients with uterine corpus endometrial carcinoma.

Uterine corpus endometrial carcinoma (UCEC) is one of the most common malignant tumours of the female genital tract. In the occurrence, progression and prognosis of UCEC, chronic inflammation plays an important role, making it pivotal to identify inflammatory response-related endometrial diseases. The cytokine interleukin-33 (IL-33) plays significant roles in immune responses, and has been associated with inappropriate allergic reactions, autoimmune diseases, and cancer pathology.

Superior Capacitive Energy Storage Enabled by Molecularly Interpenetrating Interfaces in Layered Polymers.

Polymer dielectrics are essential for advanced electronics and electrical power systems, yet they suffer from low energy density (U) due to their low dielectric constant (K) and the inverse relationship between K and breakdown stength (E). Here a scalable approach utilizing the designed molecularly interpenetrating interfaces is presented to achieve all-organic dielectric polymers with high U and charge-dischage efficiency (η). Distinctive intermolecular interactions and microstructural changes, as demonstrated experimentally and theoretically, are introduced by the molecularly interpenetrating interfaces, resulting in simultaneous improvements in dielectric responses and mechanical strength while inhibiting electrical conduction - outcomes unattainable in conventional layered polymers.