Realizing the high loading amount of active Cu on AlO to boost its CO catalytic oxidation.

Catalytic oxidation of carbon monoxide (CO) by Cu/AlO has garnered increasing interest in recent years due to its promising application prospects. Numerous investigations conducted on the Cu/AlO system, but its catalytic performance for CO oxidation is still not as promising as that of precious metal catalysts. Increasing the loading amount of the active Cu on AlO surface is a feasible method for improving its activity.

Structural characterization of a novel pentasaccharide repeating unit from Burkholderia pseudomallei strain BPC006 and its role in diagnosis and immunogenicity.

Burkholderia pseudomallei causes melioidosis - an infectious disease with high mortality. Its varied clinical manifestations and resistance to many antibiotics make it a potential biothreat agent and calls for a robust diagnostic assay and effective vaccines. Bacterial cell surface polysaccharides are considered a valuable target for diagnostics and as protective antigen candidates.

MicroRNA-146a inhibits autophagy to maintain the intracellular survival of Burkholderia pseudomallei by targeting LIPA.

Burkholderia pseudomallei is the etiological agent of melioidosis, which is an emerging infectious disease endemic to many tropical regions. Autophagy is an intrinsic cellular process that degrades cytoplasmic components and plays an important role in protecting the host against pathogens. Like many intracellular pathogens, B.

Tauroursodeoxycholic acid prevents Burkholderia pseudomallei-induced endoplasmic reticulum stress and is protective during melioidosis in mice.

Background: Burkholderia pseudomallei, a facultative intracellular bacterium, is the aetiological agent of melioidosis that is responsible for up to 40% sepsis-related mortality in epidemic areas. However, no effective vaccine is available currently, and the drug resistance is also a major problem in the treatment of melioidosis. Therefore, finding new clinical treatment strategies in melioidosis is extremely urgent.

Transcriptome Analysis Reveals Unfolded Protein Response Was Induced During the Early Stage of Infection in A549 Cells.

is a zoonotic pathogen that usually affects patients' lungs and causes serious melioidosis. The interaction of with its hosts is complex, and cellular response to infection in humans still remains to be elucidated. In this study, transcriptomic profiling of -infected human lung epithelial A549 cells was performed to characterize the cellular response dynamics during the early infection (EI) stage.

interferes with host lipid metabolism via -mediated suppression to block autophagy-dependent inhibition of infection.

: which causes melioidosis with high mortality in humans, has become a global public health concern. Recently, infection-driven lipid droplet accumulation has been related to the progression of host-pathogen interactions, and its contribution to the pathogenesis of infectious disease has been investigated. Here, we demonstrated that infection actively induced a time-dependent increase in the number and size of lipid droplets in human lung epithelial cells and macrophages.

PEI-crosslinked lipase on the surface of magnetic microspheres and its characteristics.

Here, PEI@PMMA microspheres were prepared by grafting polyethyleneimine (PEI) on poly(methyl methacrylate) (PMMA) magnetic microspheres and successfully used to immobilize lipase. The results showed that PEI@PMMA microspheres had strongly adsorbed lipase (49.1 mg/g microsphere) via electrostatic attraction.

Microporous Metal-Organic Framework with a Completely Reversed Adsorption Relationship for C Hydrocarbons at Room Temperature.

As a new type of porous material, metal-organic frameworks (MOFs) have been widely studied in gas adsorption and separation, especially in C hydrocarbons. Considering the stronger interaction between the unsaturated molecules and the metal sites, and the smaller molecular size of unsaturated molecules, the usual relationship of affinities and adsorption capacities among C hydrocarbons in most common MOFs is CH > CH > CH. Herein, a unique microporous metal-organic framework, (activated ), with a completely reversed adsorption relationship for C hydrocarbons (CH > CH > CH) has been successfully synthesized, which breaks the traditional concept of the adsorption relationship of MOFs for C hydrocarbons.

Two luminescent coordination polymers as highly selective and sensitive chemosensors for Cr-anions in aqueous medium.

Two luminescent coordination polymers (CPs), {[Cd2L2(H2O)4]·H2O}n (1) and {[Zn2L2(H2O)4]·H2O}n (2) (H2L = 5-(1H-1,2,4-triazol-1-yl)isophthalic acid) are reported herein. The CPs reveal readily dispersible two-dimensional (2D) layer structures with considerable stability in aqueous media within a wide pH range (pH = 2-12). Sensing experiments indicate that they can serve as highly selective and sensitive fluorescent probes toward CrVI-anions (CrO42- and Cr2O72-).

Efficient separation of CH from CH/CO mixtures in an acid-base resistant metal-organic framework.

A novel metal-organic framework, ZJU-196, with extraordinary acid-base resistant stability has been successfully synthesized, exhibiting highly efficient separation of acetylene from C2H2/CO2 mixtures under ambient conditions.