Population pharmacokinetics of vancomycin in Thai patients.

Population pharmacokinetics of vancomycin in Thai adult patients was determined by non-linear mixed-effects approach using 319 vancomycin serum concentrations from 212 patients. The data were best fitted by a two-compartment model and it was used to examine the effect of patient characteristics on the vancomycin pharmacokinetics. In the final model, there was a linear relationship between vancomycin clearance, CL (L/h), and creatinine clearance calculated by Cockcroft-Gault equation, CL(Cr) (mL/min): CL = 0.

Population pharmacokinetics of digoxin in Thai pediatric patients.

Objective: To determine the digoxin population pharmacokinetic parameters and influence of various factors on pharmacokinetic parameters in Thai pediatric patients with heart disease.

Material And Method: The present study was an analytical cross-sectional study design and population pharmacokinetic modeling study. The data of 130 patients and 264 samples with an age range of 0.