A near-infrared fluorescent probe for the detection of mitochondrial viscosity and its application in the imaging of Alzheimer's disease mice brain.

Viscosity is an important part of the cell microenvironment. Abnormal viscosity in the microenvironment is related to many diseases such as tumors, fatty liver and Alzheimer's disease. Accumulated β-amyloid (Aβ) fibrils and plaques are key pathological features of Alzheimer's disease, which can lead to severe neurotoxicity and cognitive and behavioral disorders.

A turn on fluorescent probe for nitroreductase activity and its application in real-time imaging of tumor hypoxia.

Nitroreductase (NTR) is an endogenous reductase overexpressed in hypoxic tumors, with its levels closely correlated to the degree of hypoxia. This correlation has significant clinical implications for the analysis of tumor hypoxia, as it allows for the indirect detection of nitroreductases. Due to their simplicity, noninvasive nature, and excellent spatiotemporal resolution, various fluorescence methods have been developed for the analysis of nitroreductase and tumor hypoxia.