Publications by authors named "Yunzhu Yao"
Article Synopsis
- The study investigates the role of oxidative stress and IFNγ-driven immune responses in the development of vitiligo, focusing on how mast cells produce IFNγ and its effects on the disease progression.* -
- Researchers analyzed skin samples from vitiligo patients and used a mouse model to explore how stress signals (like hydrogen peroxide) affect the recruitment of mast cells and CD8+ T cells to affected skin areas.* -
- Results showed that IFNγ-producing mast cells increased alongside CD8+ T cells in early vitiligo, suggesting that skin stress leads to changes in immune cell dynamics, which may contribute to the pathogenesis of vitiligo.*
Background: Few studies have addressed the impact of the psoriasis-related proinflammatory cytokines on the proliferation and melanogenesis of melanocytes (MCs) in lesional psoriatic skin.
Objective: We investigated the effects of TNFα, IL17A, and IL8 on the proliferation and melanin synthesis of MCs.
Methods: Skin specimens were biopsied from patients with psoriasis vulgaris at the active stage, or from the tail skin of Dct-LacZ mice with imiquimod (IMQ)-induced psoriasiform dermatitis.