Targeted bile acid profiles reveal the liver injury amelioration of Da-Chai-Hu decoction against ANIT- and BDL-induced cholestasis.

Multiple types of liver diseases, particularly cholestatic liver diseases (CSLDs) and biliary diseases, can disturb bile acid (BA) secretion; however, BA accumulation is currently seen as an important incentive of various types of liver diseases' progression. Da-Chai-Hu decoction (DCHD) has long been used for treating cholestatic liver diseases; however, the exact mechanisms remain unclear. Currently, our study indicates that the liver damage and cholestasis status of the α-naphthylisothiocyanate (ANIT)-induced intrahepatic cholestasis and bile duct ligation (BDL)-induced extrahepatic cholestasis, following DCHD treatment, were improved; the changes of BA metabolism post-DCHD treatment were investigated by targeted metabolomics profiling by UPLC-MS/MS.

Quality evaluation of rhubarb based on qualitative analysis of the HPLC fingerprint and UFLC-Q-TOF-MS/MS combined with quantitative analysis of eight anthraquinone glycosides by QAMS.

Rhubarb is one of the most ancient and important herbal medicines, but its current quality evaluation (QE) methods have some limitations. In this study, a new method was developed for the comprehensive QE of rhubarb. First, fingerprints of 28 batches of three species of rhubarb samples were determined by HPLC, the reference fingerprint was established and the common peaks were assigned.

[Study on the prognosis of the T1a non-small cell lung cancer].

Background And Objective: The new edition of the TNM staging for lung and pleural tumours has been finished, which put weight on the extent of primary tumor as one of the important prognosises. But little study has performed on the primary tumor extent < or = 2 cm. The aim of this study is to explore the prognosis of patients with tumor extent < or = 2 cm in stage I of non-small cell lung cancer, which helps us to choose the best treatment for these patients.

[The prognostic value of detection of serum VEGF-C level and lymphangiogenesis in mediastinal lymph nodes in the patients with lung cancer.].

Background: There is still lack of special prognostic factor on lung cancer, this study will explore the prognostic value of serum VEGF-C level and lymphangiogenesis of primary cancer and mediastinal lymph nodes in the patients with lung cancer.

Methods: Thirty patients with NSCLC would accept operation (new group) and 30 cases followed up three years postoperative (history group) were chosen respectively. The serum VEGF-C level of new group was tested.

[Effects of pulmonary veins ligation style for the patients' stress and cardiac on lung cancer.].

Background: It is needed to explore the effects of operation on stress statue, myocardial damage and arrhythmia to lung cancer. This study would compare the effects of two ligation styles of pulmonary vein on lung cancer patients' stress and cardiac postoperative.

Methods: 54 cases were divided into two groups randomly: the pulmonary vein trunk-ligation group (trunk group, 27 cases) and the pulmonary vein branch-ligation group (branch group, 27 cases).

[Effects of MVP regimen on operation and cancer tisswes of Lung Cancer patients.].

Background: Preoperative chemotherapy increases the difficulty and risk of patients' operation. The aim of this study is to analyze the change of thoracic tissue, study the influence of chemotherapy to operation, discuss the special aspects of surgical management and observe the pathological change of focus after chemotherapy.

Methods: 100 patients were chosen and randomly divided into two groups(operation first group, 50 cases; chemotherapy first group, 50 cases) .

[Trachea-bronchoplasty in the surgical treatment of locally advanced non-small cell lung cancer].

Background: Some of the locally advanced non-small cell lung cancer (NSCLC) need different trachea-bronchoplasty operative styles in order to make the widest possible to resect the tumor and remain normal pulmonary function. The aim of this study is to explore the surgical problem during trachea-bronchoplasty operation.

Methods: There were 2206 patients with NSCLC underwent surgical treatment from January 2003 to June 2005 in this hospital.

[Treatment of 40 patients with primary tracheal carcinoma].

Objective: To study the efficacy of treatment in 40 patients with primary tracheal carcinoma.

Methods: From 1970 to 2001, 40 patients with primary tracheal carcinoma treated in our hospital were retrospectively reviewed. Twenty-eight were male and 12 were female with median age of 47 years.

[Surgical treatment of apical chest tumor in 27 patients].

Objective: To explore the "hemi-clamshell" approach to the resection of the apical chest tumors, and to evaluate its advantages of operative safety and completeness.

Methods: We conducted a retrospective review of the records of 27 patients undergoing resection of the primary apical chest tumors from January 1995 to January 2001. Tumor type included NSCLC, sarcoma, neurofibromatosis, esophageal carcinoma.

[Ultrasound surveillance of cervical lymph node metastasis in thoracic esophageal carcinoma].

Objective: To improve the accuracy of preoperative evaluation of cervical lymph node metastasis in thoracic esophageal squamous carcinoma.

Methods: Forty-two patients with thoracic esophageal squamous carcinoma underwent neck ultrasonography. Enlarged lymph nodes with their long axis greater than 10 mm and a short-to-long axis ratio greater than 0.

[The study of peri-operative chemotherapy in stage I-IIIa NSCLC].

Objective: A number of studies had evaluated the benefit of neoadjuvant chemotherapy combined surgery on stage IIIa-IIIb NSCLC, survival benefit was found in several papers. We attempt to evaluate the survival and prognosis of cisplatinum-based schedule as peri-operative CT for resectable stage I-IIIa NSCLC.

Methods: A prospective, randomized, multicenter study was conducted by Shanghai Lung Cancer Team (supported by Shanghai Branch of Discipline Foundation) since 1995-1997 for 211 cases of stage I-IIIa NSCLC with curative resection (99 stage I, 47 stage II, 65 stage III), age of or= 80, staged by 1997 AJC TNM Criteria.

Hematogenous dissemination of lung cancer cells during surgery: quantitative detection by flow cytometry and prognostic significance.

Shedding of neoplastic cells into the circulation is an essential event for the hematogenous metastasis of solid tumors. Recently, several studies reported that a high frequency of cancer cells could be detected in the bloodstream during surgery. The intraoperative detection of hematogenous dissemination of cancer cells was able to identify a subset of patients with malignant diseases at high risk for postoperative metastasis and to predict a poor prognosis.