Publications by authors named "Yunzhong Wu"

Graphene has attracted much interest in many scientific fields because of its high specific surface area, Young's modulus, fracture strength, carrier mobility and thermal conductivity. In particular, the graphene oxide (GO) prepared by chemical exfoliation of graphite has achieved low-cost and large-scale production and is one of the most promising for Cu matrix composites. Here, we prepared a high strength, high electrical conductivity and high thermal conductivity reduced graphene oxide (RGO)/Cu composite by directly heating the GO/copper formate.

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Objective: To investigate the efficacy and related factors of pegylated-interferon alpha-2a (PEG-IFN-2a) treatment in patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) who achieved partial viral response with nucleoside analogue (NA) therapy.

Methods: Patients with HBeAg-positive CHB and partial viral response to NA treatment were administered a PEG-IFN-2a therapy regimen of 180 g subcutaneous injection once weekly for a personlized duration of time. The existing NA therapy was continued in combination with the new PEG-IFN-2a treatment for 12 weeks.

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Objective: A retrospective study was conducted to investigate the clinical features and prognostic factors of 73 cases of severe hepatitis.

Methods: To summarize clinical features of 73 cases of severe hepatitis, grouping by etiology and pathogenesis. A retrospective analysis was performed to evaluate the relationship between biochemical characteristics (liver function, renal function, electrolytes, PTA, etc) and complications (hepatic encephalopathy, upper gastrointestinal bleeding, hepatorenal syndrome, ascites, abdominal infections, etc) and prognosis.

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Article Synopsis
  • The study analyzed the reasons behind acute hepatitis cases in hospitalized patients at Beijing Ditan Hospital from 2002 to 2011, focusing on patient demographics and changes in hepatitis types over the years.
  • A total of 6,235 patients were admitted, with a significant majority experiencing viral hepatitis, while other causes like drug-induced liver injury were minimal.
  • Over the decade, the incidence of acute hepatitis cases fell sharply, particularly acute hepatitis A, while acute hepatitis B and E increased in prevalence among patients.
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Objective: To study the clinical features, outcomes and treatments of viral hepatitis combined with aplastic anemia.

Methods: 25 cases diagnosed as viral hepatits combined with aplastic anemia in Beijing Ditan Hsopital between April 2004 and September 2009 were retrospectively analyzed. In this group of patients aplastic anemia was finally diagnosed by bone marrow aspiration.

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Article Synopsis
  • The study aimed to explore the factors affecting viral response and HBeAg seroconversion in patients with chronic hepatitis B undergoing interferon treatment.
  • Patients received weekly PEG-IFN alfa-2a for 48 weeks, followed by a 24-week observation period, during which liver function and HBV DNA levels were measured.
  • Results showed that higher ALT levels before treatment were linked to better viral response and HBeAg seroconversion, while the baseline HBV DNA level did not significantly impact these outcomes.
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Objective: To investigate the factors related to the outcome of patients with chronic severe hepatitis B and effectiveness of antivirus therapy.

Methods: The effects of the factors including age, prothrombin activity (PTA), serum HBeAg, Anti-HBe, HBV-DNA load, with or without complication, antivirus therapy and so on, on outcome of 330 patients with chronic severe hepatitis B were analyzed in this retrospective study.

Results: The mortality of patients with chronic severe hepatitis B was significantly higher among patients at higher age, with lower PTA, and with more complications.

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Objective: To evaluate the relationship between mortality and HBVDNA and HBeAg expression of severe hepatitis B patients.

Methods: The mortality rates of different types of severe hepatitis patients in our hospital during the last five years were analysed. HBV DNA was detected using the fluorescence quantitative PCR method and the HBeAg expression of severe hepatitis B was studied using a microparticle method.

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Objective: To assess the association of polymorphisms of human leucocyte antigen (HLA) -DRB1 and -DQA1 region allele with outcomes of hepatitis B virus (HBV) infection in Han population of north China.

Methods: A total of 207 chronic hepatitis B (HB) patients, 212 chronic asymptomatic HBV carriers (HBV carrier), and 148 self-limited HBV infection were recruited to examine the association between gene polymorphisms and outcomes of HBV infection. Polymerase chain reaction-sequence specific primers (PCR-SSP) technique was used to genotype HLA-DRB1 and HLA-DQA1 loci.

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