Cost-Effective DNA Storage System with DNA Movable Type.

In the face of exponential data growth, DNA-based storage offers a promising solution for preserving big data. However, most existing DNA storage methods, akin to traditional block printing, require costly chemical synthesis for each individual data file, adopting a sequential, one-time-use synthesis approach. To overcome these limitations, a novel, cost-effective "DNA-movable-type storage" system, inspired by movable type printing, is introduced.

Co-grown novel S-scheme tubular P-UCN/S-TCN homojunction mediates photocatalysis-PMS activation synergistic system for efficient degradation of antibiotic.

The low photogenerated carrier separation and transport ability of the photocatalyst are the main factors inhibiting the photocatalytic activity. The construction of composite photocatalysts can effectively improve the efficiency of photogenerated carriers. However, the problem of reduced photocatalyst stability and catalytic activity due to easy separation of unstable composite interfaces has not been well solved for a long time.

Machine Learning-Based Detection of Bladder Cancer by Urine cfDNA Fragmentation Hotspots that Capture Cancer-Associated Molecular Features.

Background: cfDNA fragmentomics-based liquid biopsy is a potential option for noninvasive bladder cancer (BLCA) detection that remains an unmet clinical need.

Methods: We assessed the diagnostic performance of cfDNA hotspot-driven machine-learning models in a cohort of 55 BLCA patients, 51 subjects with benign conditions, and 11 healthy volunteers. We further performed functional bioinformatics analysis for biological understanding and interpretation of the tool's diagnostic capability.

Synthesis of New Isoxazolidine Derivatives Utilizing the Functionality of -Carbonylpyrazol-Linked Isoxazolidines.

Using Ni(II) as the catalyst, electron-deficient 3,5-dimethylacryloylpyrazole olefin was reacted with ,-diarylnitrones alone for 10 min to prepare novel five-member heterocyclic products, 4-3,5-dimethylacryloylpyrazole isoxazolidines with 100% regioselectivity and up to 99% yield. And then, taking these cycloadducts as substrates, six kinds of derivatization reactions, like ring-opening, nucleophilic substitution, addition-elimination and reduction, were studied. Experimental results showed that all kinds of transformations could obtain the target products at a high conversion rate under mild conditions, a finding which provided the basic methods for organic synthesis methodology research based on an isoxazolidine skeleton.

SDC-DeepLabv3+: Lightweight and Precise Localization Algorithm for Safflower-Harvesting Robots.

Harvesting robots had difficulty extracting filament phenotypes for small, numerous filaments, heavy cross-obscuration, and similar phenotypic characteristics with organs. Robots experience difficulty in localizing under near-colored backgrounds and fuzzy contour features. It cannot accurately harvest filaments for robots.

Evaluation of a Positron Emission Tomography Tracer Targeting Colony-Stimulating Factor 1 Receptor for Detecting Pulmonary Inflammation.

Colony-stimulating factor 1 receptor (CSF1R) is a type III receptor tyrosine kinase that is crucial for immune cell activation, survival, proliferation, and differentiation. Its expression significantly increases in macrophages during inflammation, playing a crucial role in regulating inflammation resolution and termination. Consequently, CSF1R has emerged as a critical target for both therapeutic intervention and imaging of inflammatory diseases.

Haplotype-based phylogenetic analysis and population genomics uncover the origin and domestication of sweetpotato.

The hexaploid sweetpotato (Ipomoea batatas) is one of the most important root crops worldwide. However, its genetic origin remains controversial, and its domestication history remains unknown. In this study, we used a range of genetic evidence and a newly developed haplotype-based phylogenetic analysis to identify two probable progenitors of sweetpotato.

Effects of profenofos on the growth, reproduction, behavior, and gene transcription of Daphnia magna.

Profenofos (PFF) is an organophosphorus pesticide frequently detected in surface waters, soil habitats, and even biota. Some studies have demonstrated the potential risks of PFF to aquatic organisms. However, most of these studies were focused on its acute rather than chronic impacts, and the subjects are usually large vertebrates.

Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design.

The positron emission tomography (PET) molecular imaging technology has gained universal value as a critical tool for assessing biological and biochemical processes in living subjects. The favorable chemical, physical, and nuclear characteristics of fluorine-18 (97% β decay, 109.8 min half-life, 635 keV positron energy) make it an attractive nuclide for labeling and molecular imaging.

Exploring and exploiting genetics and genomics for sweetpotato improvement: Status and perspectives.

Sweetpotato (Ipomoea batatas (L.) Lam.) is one of the most important root crops cultivated worldwide.

Relative Contribution of Metal Content and Soil Particle Mass to Health Risk of Chromium-Contaminated Soil.

Three soil samples from a chromium (Cr)-contaminated field were classified into five particle fractions (i.e., 0-50 μm, 50-100 μm, 100-250 μm, 250-500 μm, and 500-1000 μm) and were further characterized to study their physicochemical properties and Cr bioaccessibility.

The curative effect of Reduning injection combined with Xuanfeibaidu formula on COVID-19: A protocol for systematic review and meta-analysis.

Background: Since December 2019, COVID-19, caused by the new coronavirus (SARS-CoV-2), posed a serious threat to human health. On March 11, 2020, the World Health Organization announced that COVID-2019 has become a global pandemic. In China, Reduning injection (REDI) and Xuanfeibaidu formula (XFF) is widely used in treating COVID-19.

Triculata A, a novel compound from (D. Don) J. F. Macbr. with biological properties.

A novel compound, triculata A (), and seven known compounds were obtained from the (D. Don) J. F.

Correction: APTES assisted surface heparinization of polylactide porous membranes for improved hemocompatibility.

[This corrects the article DOI: 10.1039/C6RA04525A.].

Copper-Mediated Aromatic 1,1-Difluoroethylation with (1,1-Difluoroethyl)trimethylsilane (TMSCF2 CH3 ).

A new method for the formation of 1,1-difluoroethyl copper species ("CuCF2 CH3 ") with 1,1-difluoroethylsilane (TMSCF2 CH3 ) has been developed. The "CuCF2 CH3 " species can be applied to the efficient 1,1-difluoroethylation of diaryliodonium salts under mild conditions, affording (1,1-difluoroethyl)arenes in good to excellent yields. This convenient procedure tolerates a wide range of functional groups and thus serves as a practical synthetic tool for the introduction of CF2 CH3 group(s) into complex molecules.