Research on Signal Noise Reduction and Leakage Localization in Urban Water Supply Pipelines Based on Northern Goshawk Optimization.

In order to enhance the accuracy and adaptability of urban water supply pipeline leak localization, based on the Northern Goshawk Optimization, a novel joint denoising method is proposed in this paper to reduce noise in negative pressure wave signals caused by leaks. Firstly, the Northern Goshawk Optimization optimizes the decomposition levels and penalty factors of Variational Mode Decomposition, and obtains their optimal combination. Subsequently, the optimized parameters are used to decompose the pressure signals into modal components, and the effective components and noise components are distinguished according to the correlation coefficients.

Safety and efficacy of allogenic human amniotic epithelial cells transplantation via ovarian artery in patients with premature ovarian failure: a single-arm, phase 1 clinical trial.

Background: Premature ovarian failure (POF) is a prevalent and severe condition that impairs female health but there is currently no effective treatment available to restore ovarian function. Human amniotic epithelial cells (hAECs) exhibit ovarian protection in pre-clinical models. Thus, we conducted a single-arm, phase 1 clinical trial to assess the safety and efficacy of allogenic hAECs in treating POF.

Elevated maternal serum bile acids level, hypertensive disorders of pregnancy and adverse fetal outcomes: a cohort study of 117,789 pregnant women in China.

Background: Elevated maternal serum total bile acids (sTBA) level during pregnancy was associated with adverse fetal outcomes. Women with elevated sTBA could complicate with hepatic dysfunction or vascular disorders (hypertensive disorders of pregnancy, HDP), which aggravated adverse fetal outcomes. However, the relationships among sTBA level, hepatic dysfunction, HDP and adverse fetal outcomes were still illusive.

Genome-Wide Identification and Expression Analysis of Genes in Reveals Their Potential Roles in Abiotic Stress Tolerance.

The bile acid sodium symporter (BASS) family plays an important role in transporting substances and coordinating plants' salt tolerance. However, the function of in has not yet been elucidated. In this study, eight genes distributed on five chromosomes were identified that belonged to four subfamilies.

Relationship between pelvic floor muscle function and insulin resistance among non-diabetic females: a 3d ultrasound evaluation.

Background: To use the three-dimensional (3D) ultrasound for assessment of pelvic floor muscle function in non-diabetic females with insulin resistance (IR), and to evaluate its functional relationship with insulin levels.

Methods: From October 2022 to November 2023, 216 non-diabetic females with insulin-resistant (IR group) and 118 normal females (control group) were sequentially recruited from our hospital for our study. The 3D ultrasound was used to assess the levator hiatus in resting state for all females regarding diameter lines, perimeters and areas; as well as the Valsalva manoeuvre (VM).

Genome-Wide Identification of Genes in and Their Expression Analysis under Abiotic Stresses.

() genes belong to the gene family and have been shown to play a role in diverse processes, such as flowering time and yield regulation, as well as responses to abiotic stresses. genes have not yet been identified in . A total of 25 genes were identified in this study, and these genes were distributed across eight chromosomes.

A Hybrid Model for Fetal Growth Restriction Assessment by Automatic Placental Radiomics on T2-Weighted MRI and Multifeature Fusion.

Background: MRI-based placental analyses have been used to improve fetal growth restriction (FGR) assessment by complementing ultrasound-based measurements. However, these are still limited by time-consuming manual annotation in MRI data and the lack of mother-based information.

Purpose: To develop and validate a hybrid model for accurate FGR assessment by automatic placental radiomics on T2-weighted imaging (T2WI) and multifeature fusion.

The Gene Family and Their Potential Roles in Responses to Abiotic Stress in .

() genes play key roles in plant root and pollen tube growth, phytohormone responses, and abiotic stress responses. genes in have not yet been explored. Here, genes were found to be distributed across eight chromosomes in and were classified into three subfamilies.

Photodynamic therapy with hematoporphyrin derivative for recurrent plantar cutaneous squamous cell carcinoma: A case report.

Cutaneous squamous cell carcinoma (cSCC) is a prevalent malignant tumor typically treated through surgical removal. However, when the lesion is situated in specific areas like the hands, feet, or lips, particularly if it's sizable, surgical interventions can adversely impact appearance and function. In such cases, non-surgical treatments are preferable to preserve both aesthetics and functionality.

Nitrate Transporter 2 () Family Genes, Identification, and Their Potential Functions in Abiotic Stress Tolerance.

Nitrate transporter 2 (NRT2) proteins play vital roles in both nitrate (NO) uptake and translocation as well as abiotic stress responses in plants. However, little is known about the gene family in . In this study, 14 were identified in the genome.

Genome-Wide Identification and Expression Analysis under Abiotic Stress of Genes in .

The AT-hook motif nuclear localized () gene family is a highly conserved transcription factor critical for the growth, development, and stress tolerance of plants. However, the function of the gene family in () remains unclear. In this study, 42 family members were identified from the genome and mapped to nine chromosomes.

Can uterine artery pulsatility index predict fetal chromosomal abnormality in early pregnancy loss? A retrospective cohort study.

Background: Early pregnancy loss (EPL) or spontaneous loss of an intrauterine pregnancy within the first trimester occurs commonly worldwide. It is useful to predict the possibility of fetal chromosomal abnormalities using other cheap and easily available markers.

Objective: This study aimed to evaluate whether the uterine artery pulsatility index (UtA-PI) can predict fetal chromosomal abnormality in early pregnancy loss (EPL).

Genome-Wide Identification and Expression Analysis of Genes in Reveal Their Potential Roles in Abiotic Stress.

The () gene family plays a pivotal role in plant growth, induction of phytohormones, and the abiotic stress response. However, the gene family in has yet to be investigated. In this study, we identified 62 genes in the genome, which were classified into six subfamilies and distributed across 10 chromosomes.

Roles of hypoxic environment and M2 macrophage-derived extracellular vesicles on the progression of non-small cell lung cancer.

Background: Hypoxia contributes to the development of invasive and metastatic cancer cells, and is detrimental to cancer treatment. This study aimed to explore the molecular mechanisms by which hypoxic microenvironments affect hypoxic non-small cell lung cancer (NSCLC) development and the effects of M2 macrophage-derived extracellular vesicles (EVs) on NSCLC cells.

Methods: A549 cells were cultured in an anoxic incubator for 48 h to construct hypoxic A549 cells, and then normal and hypoxic A549 cells were harvested for RNA sequencing.

MCAS-GP: Deep Learning-Empowered Middle Cerebral Artery Segmentation and Gate Proposition.

With the fast development of AI technologies, deep learning is widely applied for biomedical data analytics and digital healthcare. However, there remain gaps between AI-aided diagnosis and real-world healthcare demands. For example, hemodynamic parameters of the middle cerebral artery (MCA) have significant clinical value for diagnosing adverse perinatal results.

Cost-effectiveness of Arg16Gly in pharmacogenomic-guided treatment for pediatric asthma.

Objectives: To assess the cost-effectiveness of Arg16Gly pharmacogenomic testing compared with no Arg16Gly testing to guide the use of long-acting β receptor agonist (LABA) in asthma patients aged 1 to 5 years in China.

Methods: This economic evaluation developed a Markov model with four health states (no exacerbation, mild exacerbation, moderate-to-severe exacerbation, and death). Transition probabilities were estimated from the rate of exacerbations, the case-fatality rate of patients hospitalized for exacerbations, and natural mortality.

Combination of a STING Agonist and Photothermal Therapy Using Chitosan Hydrogels for Cancer Immunotherapy.

Cyclic dinucleotides (CDNs) are a promising class of immune agonists that trigger the stimulator of interferon genes (STING) to activate both innate and acquired immunity. However, the efficacy of CDNs is limited by drug delivery barriers. Therefore, we developed a combined immunotherapy strategy based on injectable reactive oxygen species (ROS)-responsive hydrogels, which sustainably release 5,6-dimethylxanthenone-4-acetic acid (DMXAA) as known as a STING agonist and indocyanine green (ICG) by utilizing a high level of ROS in the tumor microenvironment (TME).

Comprehensive Analysis of BrHMPs Reveals Potential Roles in Abiotic Stress Tolerance and Pollen-Stigma Interaction in .

Heavy metal-associated proteins (HMPs) participate in heavy metal detoxification. Although HMPs have been identified in several plants, no studies to date have identified the HMPs in (). Here, we identified 85 potential HMPs in by bioinformatic methods.

Stigma receptors control intraspecies and interspecies barriers in Brassicaceae.

Flowering plants have evolved numerous intraspecific and interspecific prezygotic reproductive barriers to prevent production of unfavourable offspring. Within a species, self-incompatibility (SI) is a widely utilized mechanism that rejects self-pollen to avoid inbreeding depression. Interspecific barriers restrain breeding between species and often follow the SI × self-compatible (SC) rule, that is, interspecific pollen is unilaterally incompatible (UI) on SI pistils but unilaterally compatible (UC) on SC pistils.

Combination of Maternal Serum ESM-1 and PLGF with Uterine Artery Doppler PI for Predicting Preeclampsia.

Objective: This study aimed to determine whether the combination of pregnancy-associated endothelial cell-specific molecule 1 (ESM-1), the placental growth factor (PLGF) in the first- and second-trimester maternal serum, and the uterine artery Doppler pulsatility index (PI) in the second trimester can predict preeclampsia (PE).

Methods: The serum levels of ESM-1 and PLGF in 33 severe preeclampsia (SPE) patients, 18 mild preeclampsia patients (MPE), and 60 age-matched normal controls (CON) were measured. The Doppler ultrasonography was performed, and the artery pulsatility index (PI) was calculated for the same subjects.

Laminarin ameliorates alcohol-induced liver damage and its molecular mechanism in mice.

Alcoholic liver disease (ALD) has become a health issue globally. Laminarin, a low molecular weight marine-derived β-glucan, has been identified with multiple biological activities. In this study, the ameliorative effect on ALD of laminarin isolated from brown algae was investigated.

Targeting mTOR Signaling by Dietary Polyphenols in Obesity Prevention.

Dietary polyphenols can be utilized to treat obesity and chronic disorders linked to it. Dietary polyphenols can inhibit pre-adipocyte proliferation, adipocyte differentiation, and triglyceride accumulation; meanwhile, polyphenols can also stimulate lipolysis and fatty acid β-oxidation, but the molecular mechanisms of anti-obesity are still unclear. The mechanistic target of rapamycin (mTOR) is a protein kinase that regulates cell growth, survival, metabolism, and immunity.

Transition of ovarian granulosa cell tumor from a solid mass to a cystic mass in two months on MR imaging in an adult woman: A case report.

Ovarian granulosa cell tumor (OGCT) is a relatively rare ovarian tumor originating from ovarian sex cord-stromal cells. It is generally believed that the tumor is mainly a solid mass in the early stage, and with the volume increasing, the tumor would undergo multiple cystic changes. But few such cases have been reported.