mA-Methylated NUTM2B-AS1 Promotes Hepatocellular Carcinoma Stemness Feature via Epigenetically Activating Transcription.

Purpose: Hepatocellular carcinoma (HCC) is one of the most lethal malignancies in the world. Oncofetal proteins are the optimal diagnostic biomarkers and therapeutic targets for HCC. As the most abundant modification in RNA, N-methyladenosine (mA) has been reported to be involved in HCC initiation and progression.

METTL3 and METTL14-mediated N-methyladenosine modification of SREBF2-AS1 facilitates hepatocellular carcinoma progression and sorafenib resistance through DNA demethylation of SREBF2.

As the most prevalent epitranscriptomic modification, N-methyladenosine (mA) shows important roles in a variety of diseases through regulating the processing, stability and translation of target RNAs. However, the potential contributions of mA to RNA functions are unclear. Here, we identified a functional and prognosis-related mA-modified RNA SREBF2-AS1 in hepatocellular carcinoma (HCC).

mA modification of AC026356.1 facilitates hepatocellular carcinoma progression by regulating the IGF2BP1-IL11 axis.

N-methyladenosine (mA) is the most common RNA modification in eukaryotic RNAs. Although the important roles of mA in RNA fate have been revealed, the potential contribution of mA to RNA function in various diseases, including hepatocellular carcinoma (HCC), is still unclear. In this study, we identified a novel mA-modified RNA AC026356.

CircRBM33 regulates IL-6 to promote gastric cancer progression through targeting miR-149.

There is increasing evidence of the vital role played by circular RNAs (circRNAs) in the progression of gastric cancer (GC). A circRNA, hsa_circ_0001772, was generated from the RBM33 gene and named circRBM33. The aim of this study was to investigate the role of circRBM33 in GC.

Characterization and anti-tumor activities of sulfated polysaccharide SRBPS2a obtained from defatted rice bran.

A novel chemically sulfated polysaccharide SRBPS2a with potent anti-tumor activity was derived from defatted rice bran by chlorosulfonic acid-pyridine (CSA-Pyr) method. The average molecular weight of SRBPS2a was 3.5 x 10(5) Da and the degree of sulfation (DS) was 1.

Effect of different zinc sources and levels on inhibition of the apoptosis induced by glucocorticoid of thymocytes in vitro.

This experiment was conducted to investigate the effects of zinc sulfate and zinc methionine (Zn-Met) and their levels on apoptosis induced by glucocorticoid of thymocytes and the possible mechanism. Dexamethasone was used to make the apoptosis model of thymocytes; zinc sulfate and zinc methionine were supplemented to the medium at levels of 0, 50, 100, 500, and 1000 microM. The activity of cells, Cu,Zn superoxide dismutase (Cu,Zn-SOD), DNA ladder pattern, intracellular calcium concentration, and the percentage of apoptosis nuclei were determined.