Synthesis of molecularly imprinted polymers based on nitrogen-doped carbon dots for specific detection of chlortetracycline by reversed phase microemulsion method.

Among the tetracycline antibiotics, chlortetracycline (CTC) is the most frequently used antibiotic except for tetracycline (TC) for enhancing the ability of the organism to fight bacterial infections. The poor metabolism and degradability of CTC can cause serious health effects. Most studies have focused on the detection and analysis of TC, and research on CTC is relatively scarce.

Proton pump inhibitor-enhanced nanocatalytic ferroptosis induction for stimuli-responsive dual-modal molecular imaging guided cancer radiosensitization.

Although radiotherapeutic efficiency has been revealed to be positively correlated with ferroptosis, the neutral/alkaline cytoplasm pH value of tumor cells remains an intrinsic challenge for efficient Fenton/Fenton-like reaction-based ferroptosis induction. Herein, PEGylated hollow mesoporous organosilica nanotheranostics (HMON)-GOx@MnO nanoparticles (HGMP NPs) were designed as a ferroptosis inducer, which could specifically release Mn in tumor cells to activate the Fenton-like reaction for ferroptosis induction. Proton pump inhibitors (PPIs) were synchronously administered for cytoplasm pH level regulation by inhibiting V-H-ATPases activity, enhancing Fenton-like reaction-based ferroptosis induction.

Synthesis of fluorescent probe based on molecularly imprinted polymers on nitrogen-doped carbon dots for determination of tobramycin in milk.

Tobramycin (TOB) plays a considerable role in combating milk spoilage and preventing disease in dairy cows. However, overuse of TOB can lead to nephrotoxicity, ototoxicity, neuromuscular blockade, and hypersensitivity reactions. Here, nitrogen-doped carbon dots (N-CDs) were prepared with ethylenediamine and citric acid, then molecularly imprinted layers were obtained by imprinting of surface on the N-CDs to prepare Nitrogen-doped carbon dot-based molecularly imprinted polymers (N-CDs@MIPs).

Rapid synthesis of 'yolk-shell'-like nanosystem for MR molecular and chemo-radio sensitization.

Though amounts of attempts about nanomedicine for chemo-radiotherapy have been made, more efficient strategies for chemo-radio therapy enhancement still need to be studied and perfected. Herein, a 'yolk-shell'-like nanostructure (BiS@mBiMnO nanosystem) was facilely constructed by directly using radiosensitizer BiS nanorods (NRs) as a partial sacrificial template. Then, the chemotherapeutic drug doxorubicin (DOX) loaded PEGylated BiS@mBiMnO nanosystem (PBmB-DOX) was constructed, which could realize tumor microenvironment (TME)-responsive drug release for chemotherapy sensitivity enhancement.

Functionalized Au@Cu-Sb-S Nanoparticles for Spectral CT/Photoacoustic Imaging-Guided Synergetic Photo-Radiotherapy in Breast Cancer.

Background: Radiotherapy (RT) is clinically well-established cancer treatment. However, radioresistance remains a significant issue associated with failure of RT. Phototherapy-induced radiosensitization has recently attracted attention in translational cancer research.

Noninvasively visualize the expression of LAPTM4B protein using a novel F-labeled peptide PET probe in hepatocellular carcinoma.

Objective: Lysosomal protein transmembrane 4 beta (LAPTM4B) is selectively expressed in hepatocellular carcinoma (HCC) cells and thus a potential biomarker for diagnosing HCC. In this study, we designed a novel F-labeled PET probe to non-invasively visualize LAPTM4B expression in mouse model of HCC tumor.

Methods: A PET targeting tracer named [F]FP-LAP2H was radio-synthesized using a LAPTM4B targeting peptide, LAP2H, coupled with 4-nitrophenyl-2-[F]fluoropropionate ([F]NFP).

[F-FDG PET/CT manifestations of massive type active pulmonary tuberculosis and its differentiation from lung cancer].

Objective: To investigate F-FDG PET/CT manifestations of massive type active tuberculosis and lung cancer and the differential diagnosis of the two diseases based on F-FDG PET/CT findings.

Methods: We retrospectively collected the data from 74 patients with active tuberculosis and 64 patients with lung cancer, whose lesions presented as solid masses on CT. The demographic and clinical data of the patients, F-FDG PET characteristics including SUVmax, F-FDG uptake (higher than mediastinal blood pool or not), radioactive defect within the lesion, and the CT findings including the lesion size, signs of cavity, vacuoles, lobulation, smooth border, and mediastinal/lung window ratio (M/L ratio) of the lesions were analyzed.

Synthesis and Evaluation of F-Labeled Peptide for Gonadotropin-Releasing Hormone Receptor Imaging.

The gonadotropin-releasing hormone (GnRH) receptor is overexpressed in the majority of tumors of the human reproductive system. The purpose of this study was to develop an F-labeled peptide for tumor GnRH receptor imaging. In this study, the GnRH (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH) peptide analogues FP-d-Lys-GnRH (FP = 2-fluoropropanoyl) and NOTA-P-d-Lys-GnRH ( = ethylene glycol) were designed and synthesized.

Utility of Maximum Standard Uptake Value as a Predictor for Differentiating the Invasiveness of T1 Stage Pulmonary Adenocarcinoma.

Background: The present study was performed to investigate the maximum standardized uptake value (SUVmax) in 2-[fluorine-18]-fluoro-2-deoxy-d-glucose (F-FDG) positron emission tomography/computed tomography (PET/CT) to preoperatively distinguish invasive from less-invasive pulmonary adenocarcinoma.

Patients And Methods: A total of 106 patients with resectable pulmonary adenocarcinoma (≤ 3 cm) who had undergone whole-body F-FDG PET/CT were enrolled. The SUVmax, diameter, and consolidation/tumor (C/T) ratio of the lung tumors were measured with F-FDG PET/CT and regional thin-section CT.

Prognostic value of F-fluorodeoxyglucose PET parameters and inflammation in patients with nasopharyngeal carcinoma.

The aim of the present study was to investigate the association between positron emission tomography (PET) parameters and peripheral inflammatory markers, and assess their prognostic value in nasopharyngeal carcinoma (NPC). A total of 121 patients with non-disseminated NPC were recruited. Pretreatment maximum standardized uptake values (SUVmax) of PET and peripheral inflammatory factors (leukocyte, neutrophil and monocyte counts) were recorded.

[Combined use of thin-section CT and F-FDG PET/CT for characterization of solitary pulmonary nodules].

Objective: To investigate whether fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) combined with thin-section CT improves the diagnostic performance for solitary pulmonary nodules (SPNs).

Methods: A total of 267 patients underwent examinations with 18F-FDG PET/CT and thin-section CT for evaluating the SPNs with undetermined nature, which was further confirmed by pathological examination or clinical follow-up. The performance of two diagnostic criteria based on findings in PET/CT alone (Criterion 1) and in PET/CT combined with thin-section CT (Criterion 2) were compared.

18F-FDG super bone marrow uptake: A highly potent indicator for the malignant infiltration.

The present study was performed to investigate whether the markedly 2-deoxy-2-(fluorine-18) fluoro-D-glucose (F-FDG) uptake in the bone marrow (BM) is a presentation of malignant infiltration (MI).Super bone marrow uptake (super BMU) was used to name the markedly F-FDG uptake on BM, which was similar to or higher than that of the brain. From April 2008 to December 2015, 31 patients with such presentation were retrospectively reviewed.