Neural mechanisms of non-pharmacological interventions in patients with mild cognitive impairment and Alzheimer's disease: An ALE meta-analysis.

Non-pharmacologic interventions are effective for persons showing mild cognitive impairment (MCI) and Alzheimer's disease (AD). We used activation likelihood estimation (ALE) meta-analysis to systematically quantify the results of 19 neuroimaging studies in order to identify brain regions in which patients showed stable increases or decreases in activation after interventions. We also tested the moderating effects of disease stage (MCI vs.

Neural evidence of implicit emotion regulation deficits: An explorative study of comparing PTSD with and without alcohol dependence.

Background: Previous studies have identified psychiatric comorbidity, including alcohol dependence (AD), as a significant factor in treating posttraumatic stress disorder (PTSD), there is a lack of evidence on how best to treat comorbid PTSD and AD. Poor emotion regulation may be a key potential mechanism of PTSD and AD comorbidity.

Methods: Seventy-four participants (48 women and 26 men) include three groups: a healthy control group (HC group, N = 20), a PTSD without alcohol dependence group (PTSD without AD group, N = 36), and a PTSD with alcohol dependence group (PTSD with AD group, N = 18).

Intrinsic disruption of white matter microarchitecture in major depressive disorder: A voxel-based meta analysis of diffusion tensor imaging.

Background: Major depressive disorder (MDD) is a prevalent and disabling mood disorder, thought to be linked with brain white matter (WM) alterations. Prior diffusion tensor imaging (DTI) studies have reported inconsistent changes in fractional anisotropy (FA) across different brain regions in MDD patients. However, none of these studies utilized raw t-map data for WM meta-analysis in MDD.