Role and mechanism of IL-33 in bacteria infection related gastric cancer continuum: From inflammation to tumor progression.

Gastric cancer, a globally prevalent malignant tumor, is characterized by low early diagnosis rate, high metastasis rate, and poor prognosis, particularly in East Asia, Eastern Europe, and South America. Helicobacter pylori (H. pylori) is recognized as the primary risk factor for gastric cancer.

Comprehensive review on leucine-rich pentatricopeptide repeat-containing protein (LRPPRC, PPR protein): A burgeoning target for cancer therapy.

Leucine-rich pentatricopeptide repeat-containing (LRPPRC), known as the gene mutations that cause Leigh Syndrome French Canadian, encodes a high molecular weight PPR protein (157,905 Da), LRPPRC. LRPPRC binds to DNA, RNA, and proteins to regulate transcription and translation, leading to changes in cell fate. Increasing evidence indicates that LRPPRC plays a pivotal role in various human diseases, particularly cancer in recent years.

Design, synthesis, and biological evaluation of novel 5,7,4'-trimethoxyflavone sulfonamide-based derivatives as highly potent inhibitors of LRPPRC/STAT3/CDK1.

Leucine-rich pentatricopeptide repeat-containing protein (LRPPRC), signal transducer and activator of transcription 3 (STAT3), and cyclin-dependent kinase 1 (CDK1) are promising therapeutic targets for cancer treatment. However, there is a lack of effective inhibitors of LRPPRC, STAT3, and CDK1 in clinic. Our previous study has proved that 5,7,4'-Trimethoxyflavone (TMF) is a novel inhibitor of LRPPRC/STAT3/CDK1.

Construction and excellent photoelectric synergistic anticorrosion performance of Z-scheme carbon nitride/tungsten oxide heterojunctions.

The use of heterojunctions for metal corrosion protection is a highly innovative and challenging task. Based on the composition and structure of tungsten oxide-based heterojunctions, Z-scheme heterojunctions were designed and synthesized by the electrostatic self-assembly method using energy band-matched g-CN and WO materials. Applied in the field of anticorrosion, they overcame the problems of poor reduction ability and transmission inefficiency of traditional materials.

Downregulation of reelin predicts poor prognosis for glioma.

In the present study, we studied the relationship between and prognosis in glioma. Expression profiles and methylation data of were obtained from bioinformatic datasets. Correlations between and clinicopathological features and overall survival were respectively assessed using chi-square test and Kaplan-Meier analysis.