Publications by authors named "Yunxiao Ge"

Gastric cancer, a globally prevalent malignant tumor, is characterized by low early diagnosis rate, high metastasis rate, and poor prognosis, particularly in East Asia, Eastern Europe, and South America. Helicobacter pylori (H. pylori) is recognized as the primary risk factor for gastric cancer.

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Leucine-rich pentatricopeptide repeat-containing (LRPPRC), known as the gene mutations that cause Leigh Syndrome French Canadian, encodes a high molecular weight PPR protein (157,905 Da), LRPPRC. LRPPRC binds to DNA, RNA, and proteins to regulate transcription and translation, leading to changes in cell fate. Increasing evidence indicates that LRPPRC plays a pivotal role in various human diseases, particularly cancer in recent years.

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Leucine-rich pentatricopeptide repeat-containing protein (LRPPRC), signal transducer and activator of transcription 3 (STAT3), and cyclin-dependent kinase 1 (CDK1) are promising therapeutic targets for cancer treatment. However, there is a lack of effective inhibitors of LRPPRC, STAT3, and CDK1 in clinic. Our previous study has proved that 5,7,4'-Trimethoxyflavone (TMF) is a novel inhibitor of LRPPRC/STAT3/CDK1.

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Article Synopsis
  • The JAK2/STAT3/MYC signaling pathway is altered in about 70% of human cancers, making it a challenging target for cancer treatment.
  • A study identified the gene LRPPRC as significant in this context, acting as an independent prognostic marker and affecting the RNA modification process of JAK2, STAT3, and MYC.
  • The research also highlights a compound, 5,7,4'-trimethoxyflavone, that disrupts interactions within the LRPPRC-JAK2-STAT3 complex, leading to reduced tumor growth in preclinical models of esophageal squamous cell carcinoma (ESCC).
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The use of heterojunctions for metal corrosion protection is a highly innovative and challenging task. Based on the composition and structure of tungsten oxide-based heterojunctions, Z-scheme heterojunctions were designed and synthesized by the electrostatic self-assembly method using energy band-matched g-CN and WO materials. Applied in the field of anticorrosion, they overcame the problems of poor reduction ability and transmission inefficiency of traditional materials.

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In the present study, we studied the relationship between and prognosis in glioma. Expression profiles and methylation data of were obtained from bioinformatic datasets. Correlations between and clinicopathological features and overall survival were respectively assessed using chi-square test and Kaplan-Meier analysis.

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Article Synopsis
  • * MGARP has a unique structure with additional amino acid repeats found in mouse and rat versions, and is localized in mitochondria, suggesting it plays a crucial role in maintaining mitochondrial shape and function.
  • * Analysis indicates that MGARP may be involved in assembling ion channels in mitochondrial membranes and could influence retinal energy metabolism, making it a valuable target for further research in retinal health.
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