Parental influence on Chinese childhood cancer survivors' physical activity: a mixed methods study.

Parents influence the physical activity (PA) of the childhood cancer survivors (CCS). This mixed-methods study, aiming to obtain an understanding of Chinese parents' perceptions of PA in CCS and how the cancer experience changes their views, which may affect these children's PA engagement. A mixed methods study was conducted at two hospitals in Hangzhou.

Applied theory of planned behavior to explore associated factor of physical activity level among Chinese childhood cancer survivors.

Objective: Low physical activity (PA) levels are common among childhood cancer survivors (CCS) and have a serious negative impact on their physical recovery and long-term health. This study aimed to explore the factors that contribute to low levels of PA from the perspective of children themselves and how these factors affect their PA.

Methods: In this cross-sectional survey, CCS were recruited by purposive sampling from several children's medical centers nationwide.

Promoting Parental Loyalty Through Social Responsibility: The Role of Brand Trust and Perceived Value in Chinese Kindergartens.

The role of social responsibility in kindergartens is critical for fostering parental loyalty, especially amid declining enrollment rates in China. However, the relationship between kindergarten social responsibility, brand trust, perceived value, and parental loyalty is not well understood. This study investigates the influence of kindergarten social responsibility on parental loyalty, focusing on the mediating roles of brand trust and perceived value.

Conjugated Coordination Polymer Aerogels with Increased Accessibility of Well-Defined Single-Atom Metal Sites as a New Paradigm of Electrocatalysts.

Developing high-performance single-atom catalysts (SACs) with maximum metal utilization efficiency is of significance, which presents enormous potentials to be extensively applied. It is desired yet challenging to elaborately tailor the coordination structures of active sites in SACs and simultaneously enable sufficient accessibility of these active sites to reactants. Here, a facile and general strategy to prepare conjugated coordination polymer aerogels (CCPA) with porous architectures that can markedly increase the accessibility of their elaborately-tailored active sites, which as a new electrocatalyst paradigm can fully present both the structural advantages of SACs and aerogel materials, is reported.

LncRNA-Associated ceRNA Network Revealing the Potential Regulatory Roles of Ferroptosis and Immune Infiltration in Osteosarcoma as well as Construction of the Prognostic Model.

Background: Osteosarcoma (OS) is the most common primary bone malignancy in the world. Increasing studies indicate that long non-coding RNAs (lncRNAs) are involved in ferroptosis and OS progression. Therefore, this study aims to identify ferroptosis- related lncRNAs (frlncRNAs), explore potential competing endogenous RNA (ceRNA) networks, and establish a new model for predicting OS prognosis.

Correction: Wu et al. Synthesis of Spirooxindole--Naphthoquinone-Tetrazolo[1,5-]Pyrimidine Hybrids as Potential Anticancer Agents. 2018, , 2330.

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Branched-chain amino acids promote hepatic Cyp7a1 expression and bile acid synthesis via suppressing FGF21-ERK pathway.

Branched-chain amino acids (BCAAs) including leucine, isoleucine and valine have been linked with metabolic and cardiovascular diseases. BCAAs homeostasis is tightly controlled by their catabolic pathway. BCKA dehydrogenase (BCKD) complex is the rate-limiting step for BCAA catabolism.

Exploring the spatiotemporal effects of meteorological factors on hand, foot and mouth disease: a multiscale geographically and temporally weighted regression study.

The influence of meteorological factors on hand, foot, and mouth disease (HFMD) is not on the same scale, it's rare for previous studies to measure and recognize the independent regression relationship between each variable in space and time scale. This study used a multiscale geographically and temporally weighted regression (MGTWR) model to explore the relationship between the incidence of HFMD and related meteorological factors in Shandong Province, China, during 2015-2019 and attempted to quantify the influence of meteorological factors on HFMD under different spatiotemporal effects. Meanwhile, we used the Global Moran's I statistic and Local Moran's I statistic to test the spatial autocorrelation of the incidence of HFMD.

Circ_0001741 exerts as a tumor promoter in ovarian cancer through the regulation of miR-491-5p/PRSS8 axis.

Background: Circular RNAs (circRNAs) are important regulators for ovarian cancer (OC). Circ_0001741 has been found to be highly expressed in OC samples and is involved in regulating paclitaxel resistance in OC cells. Therefore, circ_0001741 may play a vital role in OC process, and its potential molecular mechanism is worth further revealing.

Accelerating the reaction kinetics of NiO/Ni(OH)/NF by defect engineering for urea-assisted water splitting.

Developing electrocatalysts with fast reaction kinetics for the urea oxidation reaction (UOR) in the field of sustainable hydrogen production through urea-assisted water splitting remains challenging. Here, NiO/Ni(OH) supported on nickel foam (NiO/Ni(OH)/NF) is prepared a defect engineering strategy by combining Zn doping and acid etching. The doped Zn species are partially removed, facilitating the formation of NiOOH during acid etching.

Constructing a Nomogram for Predicting Pelvic Osteosarcoma: A Retrospective Study Based on the SEER Database and a Chinese Cohort.

Generally, pelvic osteosarcoma has a worse prognosis compared with limb osteosarcoma. This study aims to create and validate a new nomogram for predicting the prognosis of pelvic osteosarcoma. Clinical data of 62 patients derived from the Surveillance, Epidemiology, and End Results (SEER) database and 31 Chinese patients diagnosed with pelvic osteosarcoma were gathered.

Adapting cytoskeleton-mitochondria patterning with myocyte differentiation by promyogenic PRR33.

Coordinated cytoskeleton-mitochondria organization during myogenesis is crucial for muscle development and function. Our understanding of the underlying regulatory mechanisms remains inadequate. Here, we identified a novel muscle-enriched protein, PRR33, which is upregulated during myogenesis and acts as a promyogenic factor.

Atomically Dispersed Iridium on Polyimide Support for Acidic Oxygen Evolution.

Designing a high-performing iridium (Ir) single-atom catalyst is desired for acidic water electrolysis, which shows enormous potential given its high catalytic activity toward acidic oxygen evolution reaction (OER) with minimum usage of precious Ir metal. However, it still remains a substantial challenge to stabilize the Ir single atoms during the OER operation without sacrificing the activity. Here, we report a high-performing OER catalyst by immobilizing Ir single atoms on a polyimide support, which exhibits a high mass activity on a carbon paper electrode while simultaneously achieving outstanding stability with negligible decay for 360 h.

Lethal Immune-Related Pneumonitis after Durvalumab Therapy for Small Cell Lung Cancer: A First Case in China.

Introduction: Although programmed death ligand 1 (PD-L1) inhibitor plus chemotherapy regimen is a promising strategy for malignant tumors, it can induce significant immune-related adverse events, such as immune-related pneumonitis. Here, we report the first case of lethal immune-related pneumonitis in an Asian patient receiving anti-PD-L1 treatment.

Case Presentation: A 68-year-old man was diagnosed with small cell lung cancer and interstitial pneumonia.

Glucagon Receptor Antagonist for Heart Failure With Preserved Ejection Fraction.

Background: Heart failure with preserved ejection fraction (HFpEF) is an emerging major unmet need and one of the most significant clinic challenges in cardiology. The pathogenesis of HFpEF is associated with multiple risk factors. Hypertension and metabolic disorders associated with obesity are the 2 most prominent comorbidities observed in patients with HFpEF.

High-Entropy Perovskite Oxides as a Family of Electrocatalysts for Efficient and Selective Nitrogen Oxidation.

Electrocatalytic nitrogen oxidation reaction (NOR) can convert nitrogen (N) into nitrate (NO) under ambient conditions, providing an attractive approach for synthesis of NO, alternative to the current approach involving the harsh Haber-Bosch and Ostwald oxidation processes that necessitate high temperature, high pressure, and substantial carbon emission. Developing efficient NOR catalysts is a prerequisite, which remains a formidable challenge, owing to the weak activation/dissociation of N. A variety of NOR electrocatalysts have been developed, but their NOR kinetics are still extremely sluggish, resulting in inferior Faradaic Efficiencies.

Effects of a novel regimen of repetitive transcranial magnetic stimulation (rTMS) on neural remodeling and motor function in adult male mice with ischemic stroke.

Neuroinflammation caused by excessive microglial activation plays a key role in the pathogenesis of ischemic stroke. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulatory technique that has recently been reported to regulate microglial functions and exert anti-inflammatory effects. The intermittent burst stimulation (iTBS) regimen in rTMS improves neuronal excitability.

Heterogeneous Oxidase-Type Catalysis for H Generation at Low Temperatures.

The long-term objective in the field of heterogeneous catalysis is to develop an enzyme-like catalytic pathway that can achieve exceptional catalytic performance even at low temperatures. Herein, we have demonstrated a heterogeneous oxidase-type catalysis on the ZnO-supported Ru clusters (Ru/ZnO) for efficient H generation from an aqueous solution of formaldehyde (HCHO) at low temperatures. Due to its unique reaction pathway, the Ru/ZnO catalysts exhibited a temperature-insensitive activity for H generation at the temperature of 15 to 45 °C.

Evaluating the spatial accessibility and spatial layout optimization of HIV/AIDS healthcare services in Shandong Province, China.

Improving access to HIV/AIDS healthcare services is of great concern to government and policymakers striving to strengthen overall public health. How to reasonably allocate HIV/AIDS healthcare resources and maximize the equality of access to healthcare services across subdistrict areas has become an urgent problem to be solved. However, there is limited research on this topic in China.

Highly Active and Sintering-Resistant Pt Clusters Supported on FeO-Hydroxyapatite Achieved by Tailoring Strong Metal-Support Interactions.

The catalytic performance of supported metal catalysts is closely related to their structure. While Pt-based catalysts are widely used in many catalytic reactions because of their exceptional intrinsic activity, they tend to deactivate in high-temperature reactions, requiring a tedious and expensive regeneration process. The strong metal-support interaction (SMSI) is a promising strategy to improve the stability of supported metal nanoparticles, but often at the price of the activity due to either the coverage of the active sites by support overlay and/or the too-strong metal-support bonding.

Targeting DNMT3A-mediated oxidative phosphorylation to overcome ibrutinib resistance in mantle cell lymphoma.

The use of Bruton tyrosine kinase (BTK) inhibitors such as ibrutinib achieves a remarkable clinical response in mantle cell lymphoma (MCL). Acquired drug resistance, however, is significant and affects long-term survival of MCL patients. Here, we demonstrate that DNA methyltransferase 3A (DNMT3A) is involved in ibrutinib resistance.

Independent Validation of the BRENDA-Score Breast Cancer Prognosis Prediction Tool In Chinese Patients.

Background: The BRENDA-Score was developed and used to predict the prognosis of patients with breast cancer (BC). This study was performed to validate the use of this tool in Chinese patients with primary invasive BC patients.

Methods: Patients underwent surgery for BC from January 2009 to December 2016.

Circular RNA hsa_circ_0051246 acts as a microRNA-375 sponge to promote the progression of gastric cancer stem cells YAP1.

Background: Gastric cancer (GC) stem cells play an important role in GC progression. Circular RNAs (circRNAs) act as microRNA (miRNA) sponges and inhibit the biological function of miRNAs in GC cytoplasm. MiRNAs also participate in GC progress.