Publications by authors named "Yunxi Zhao"

Underlying surface in lake watersheds and mercury concentrations in lake inflows are key factors affecting the accumulation of mercury in lake sediments. Lake characteristics play a crucial role in the process of mercury methylation in sediments. Lakes in cold regions have unique environmental features, including a long ice-cover period, during which mercury undergoes complex physicochemical processes.

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Article Synopsis
  • - The study examines how lake ice affects the movement and transformation of mercury (Hg) and methylmercury (MeHg) in high-latitude lakes during winter, specifically focusing on Wuliangsuhai Lake in China.
  • - Researchers measured mercury and methylmercury levels in lake ice for the first time and found that while the lake ice and water are not polluted, some sediment areas show slight pollution levels, with notable correlations between mercury levels and ice thickness.
  • - The study reveals that methylmercury levels in water are higher during the freezing period compared to non-freezing times, indicating a stronger migration ability for methylmercury, largely due to changes in light intensity affecting methylation processes. *
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Mercury and arsenic are two highly toxic pollutants, and many researchers have explored the effects of the two substances on the environment. However, the research content of toxic substances in frozen periods is relatively small. To explore the spatial and vertical distribution of mercury and arsenic in the ice, water, and sediments of Wuliangsuhai Lake under ice conditions, and to assess the harm degree of the two toxic substances to human beings.

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Heavy metals (HMs) in aquatic environments are characterized by high toxicity, a propensity for bioaccumulation, and non-degradability, and pose significant risks to biological communities. Previous studies of HMs in lakes have shown that the physical and chemical characteristics of the lake water may control both the migration of HMs in the sediments and the concentration of heavy metals in the lake water. In fact, the change in aquatic environments changes the heavy metal fraction in the sediment, which controls the release of HMs.

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Predicting individual behavior is a crucial area of research in neuroscience. Graph Neural Networks (GNNs), as powerful tools for extracting graph-structured features, are increasingly being utilized in various functional connectivity (FC) based behavioral prediction tasks. However, current predictive models primarily focus on enhancing GNNs' ability to extract features from FC networks while neglecting the importance of upstream individual network construction quality.

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The early stages of human development are increasingly acknowledged as pivotal in laying the groundwork for subsequent behavioral and cognitive development. Spatiotemporal (4D) brain functional atlases are important in elucidating the development of human brain functions. However, the scarcity of such atlases for early life stages stems from two primary challenges: (1) the significant noise in functional magnetic resonance imaging (fMRI) that complicates the generation of high-quality atlases for each age group, and (2) the rapid and complex changes in the early human brain that hinder the maintenance of temporal consistency in 4D atlases.

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Acute lung injury (ALI) and inflammatory bowel disease (IBD) are common inflammatory illnesses that seriously affect people's health. Herein, a series of 4-hydroxylcoumarin (4-HC) derivatives were designed and synthesized. The inhibitory effects of these compounds on LPS-induced interleukin-6 (IL-6) release from J774A.

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Article Synopsis
  • Ecological pollution from heavy metals like lead (Pb) and chromium (Cr) released from sediments is a global issue, with this study focusing on changes in sediment speciation during the ice period of Wuliangsuhai.
  • The research found that the total concentration of Pb ranged from 11.17 to 24.25 mg/kg and Cr from 42.26 to 69.68 mg/kg, indicating mild contamination, while the release of these metals is affected by factors like temperature, pH, and salinity.
  • Specifically, higher temperatures increased the release of Pb and Cr by altering their sediment forms, while higher pH usually reduced their release, and salinity had a more complex impact on their release dynamics
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Hydrogen therapy shows great promise as a versatile treatment method for diseases associated with the overexpression of reactive oxygen and nitrogen species (RONS). However, developing an advanced hydrogen therapy platform that integrates controllable hydrogen release, efficient RONS elimination, and biodegradability remains a giant technical challenge. In this study, we demonstrate for the first time that the tungsten bronze phase HWO (HWO) is an exceptionally ideal hydrogen carrier, with salient features including temperature-dependent highly-reductive atomic hydrogen release and broad-spectrum RONS scavenging capability distinct from that of molecular hydrogen.

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Background Myocardial infarction (MI) is a cardiovascular disease with high morbidity and mortality. PI16 (peptidase inhibitor 16), as a secreted protein, is highly expressed in heart diseases such as heart failure. However, the functional role of PI16 in MI is unknown.

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Reactive oxygen species (ROS) play an essential role in macrophage polarization. However, the adverse effects of ROS reduction by influencing epigenetics are often ignored. In this study, lipopolysaccharide (LPS) was used to stimulate macrophages to increase the ROS in cells, and N-acetylcysteine (NAC) was used to reduce ROS.

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Ginkgolide A (GA), a main terpenoid extracted from Ginkgo biloba, possesses biological activities such as anti-inflammatory, anti-tumor, and liver protection. However, the inhibitory effects of GA on septic cardiomyopathy remain unclear. This study aimed to explore the effects and mechanisms of GA in countering sepsis-induced cardiac dysfunction and injury.

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In a recent study, the PD-1 inhibitor has been widely used in clinical trials and shown to improve various cancers. However, PD-1/PD-L1 inhibitors showed a low response rate and were effective for only a small number of cancer patients. Thus, it is important to figure out the issue about the low response rate of immunotherapy.

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Acute lung injury (ALI) refers to a common and life-threatening disease attributed to inflammation. However, effective drug treatments have been rare for ALI. Natural products have been considered as a vital source of drug discovery which indicates that it's a workable method to find new anti-inflammatory drugs in natural products.

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Objective: To observe the therapeutic effect of acupuncture for slimming.

Methods: Eighty cases of simple obesity were randomly divided into an acupuncture group and a medication group, 40 cases in each group. The acupuncture group were treated with body acupuncture, electroacupuncture and auricular acupoint taping and pressing, with Tianshu (ST 25), Guanyuan (CV 4), Sanyinjiao (SP 6) etc.

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