Publications by authors named "Yunsoo Choe"
Background: Previous studies on the associations of per- and polyfluoroalkyl substances (PFASs) and heavy metals with lipid profiles among adolescents have been scarce. We sought to investigate the associations of PFASs and heavy metals with blood lipid levels in a representative sample of Korean adolescents.
Methods: Data from the Korean National Environmental Health Survey (2018-2020) were used.
Purpose: Few data on the clinical course after levothyroxine (L-T4) discontinuation in pediatric patients with Hashimoto thyroiditis (HT) are available. We investigated outcomes and predictors for successful withdrawal from L-T4 among children with HT.
Methods: Among 168 patients diagnosed with HT between January 2000 and March 2021 at Seoul National University Children's Hospital and in whom L-T4 therapy was initiated during childhood, we attempted to discontinue this therapy in 47, 3 boys and 44 girls.
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Article Synopsis
- The study investigates how exposure to endocrine-disrupting chemicals (EDCs) during pregnancy and childhood affects early breast development (thelarche) in girls, specifically before age 8.
- Researchers analyzed data from 211 girls, focusing on chemicals like cadmium, lead, mercury, bisphenol-A (BPA), and others from prenatal samples and assessed breast development through Tanner staging.
- Results revealed that higher prenatal exposure to cadmium increased the likelihood of early thelarche, while prenatal exposure to BPA appeared to lower this risk; however, no significant associations were found with chemical exposures at age 8.
Effects of the COVID-19 pandemic on serum vitamin D concentration in Korean children.
Ann Pediatr Endocrinol Metab
August 2024
Article Synopsis
- The study examines the impact of COVID-19-induced social distancing on vitamin D levels in South Korean children and adolescents aged 3-18 years.
- A total of 506 matched subjects were assessed, revealing no significant differences in overall vitamin D levels or deficiency rates between pre-COVID-19 and during the pandemic.
- However, a decrease in vitamin D levels was noted during the winter/spring seasons of the pandemic, highlighting the importance of monitoring and potential supplementation, especially during these high-risk seasons.
Monthly versus daily administration of vitamin D3 in children: a retrospective propensity score-matched study.
Front Endocrinol (Lausanne)
February 2024
Objectives: We aimed to evaluate the efficacy and safety of monthly vitamin D3 administration compared to a daily dosing regimen in healthy children with vitamin D deficiency.
Methods: This retrospective study included vitamin D deficient (serum 25-hydroxyvitamin D [25(OH)D] < 20 ng/mL) children with precocious puberty who received gonadotropin-releasing hormone agonist every 4 weeks between December 2019 and November 2022. We used propensity scores to 1:1 match daily (1,000 IU daily) and monthly (25,000 IU per 4 weeks) administration of vitamin D3 based on age, sex, body mass index Z-scores, season of blood collection, and baseline serum 25(OH)D concentrations.
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- The study examines how climate change has affected the annual variations in fungal spore concentrations and allergic sensitization rates in the Seoul Metropolitan Area over 25 years (1998-2022).
- Researchers analyzed fungal spores and pollen, along with the allergic responses of over 21,000 patients, finding a significant decrease in allergenic fungal sensitization rates while pollen concentrations increased.
- The results suggest that climate changes may be linked to reduced fungal spore levels and allergic reactions, highlighting the need for further research to confirm these trends and understand the broader implications of climate change on allergies.
Objectives: This study aimed to investigate the effect of rapid weight gain (RWG) on the incidence of central precocious puberty (CPP) using nationwide population-based data.
Methods: A total of 253,967 children (101,841 boys and 152,126 girls) who underwent regular health consultations under the National Health Insurance Service from 2007 to 2010 were followed up until the age of 10 years for boys and 9 years for girls. We calculated differences in the weight Z-scores from 4-6 months to 9-12 months (infancy) and from 9-12 months to 18-24 months or 30-36 months (toddlerhood) using the lambda-mu-sigma method.
Article Synopsis
- The study explored the relationship between 25-hydroxyvitamin D (25OHD) levels and type 1 diabetes (T1DM), focusing on vitamin D deficiency potentially contributing to T1DM and diabetic ketoacidosis (DKA).
- It involved 84 T1DM patients and matched healthy controls, measuring total, free, and bioavailable 25OHD using advanced laboratory techniques.
- The results indicated that T1DM patients had lower total and vitamin D binding protein (VDBP) levels but higher free 25OHD levels compared to controls, and those with DKA had significantly lower bioavailable 25OHD levels, correlating with increased severity of acidosis.
Autosomal recessive hypophosphatemic rickets type 2 (ARHR2) is a rare form of hereditary rickets, which is characterized by defective bone mineralization and renal phosphate wasting due to a loss-of-function variant in the ectonucleotide pyrophosphatase/phosphodiesterase 1 () gene. Although pathogenic variant of has been known to manifest other phenotypes including arterial calcification, hearing loss, ossification of posterior longitudinal ligament, or pseudoxanthoma elasticum, there have been few reports including systematic examination in individuals diagnosed with ARHR2 to date. Herein, we report a case of ARHR2 with a bi-allelic pathogenic variant of , in which the patient presented with gait abnormalities with severe genu varum at 26 months of age.
View Article and Find Full Text PDFPurpose: Hypoparathyroidism (hypoPTH) is the most common complication following thyroidectomy. We investigated the frequency and risk factors of hypoPTH after total thyroidectomy (TT) in pediatric patients with thyroid cancer.
Methods: This retrospective study included 98 patients younger than 20 years who were diagnosed with thyroid cancer after T T during 1990-2018 and followed for more than 2 years at Seoul National University Hospital.
There is increasing use of modern devices in the management of patients with type 1 diabetes (T1D). We investigated temporal trends for diabetes management and outcomes in Korean pediatric T1D patients over 10 years. We retrospectively collected the data from 752 participants (boys: 311, 41.
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