Concomitant NAFLD Facilitates Liver Metastases and PD-1-Refractory by Recruiting MDSCs via CXCL5/CXCR2 in Colorectal Cancer.

Background & Aims: Both nonalcoholic fatty liver disease (NAFLD) and colorectal cancer (CRC) are prevalent worldwide. The effects of concomitant NAFLD on the risk of colorectal liver metastasis (CRLM) and its mechanisms have not been definitively elucidated.

Methods: We observed the effect of concomitant NAFLD on CRLM in the mouse model and explored the underlying mechanisms of specific myeloid-derived suppressor cells (MDSCs) recruitment and then tested the therapeutic application based on the mechanisms.

Using machine learning to estimate the incidence rate of intimate partner violence.

It is difficult to accurately estimate the incidence rate of intimate partner violence (IPV) using traditional social survey methods because IPV victims are often reluctant to disclose their experiences, leading to an underestimation of the incidence rate. To address this issue, we applied machine learning algorithms to predict the incidence rate of IPV in China based on data from the Third Wave Survey on the Social Status of Women in China (TWSSSCW 2010). Specifically, we examined five unbalanced sample-processing methods and six machine learning algorithms, choosing the random under-sampling ensemble method and the random forest algorithm to impute the missing data.

Effects of Sulfamethoxazole and Florfenicol on Growth, Antioxidant Capacity, Immune Responses and Intestinal Microbiota in Pacific White Shrimp at Low Salinity.

Antibiotic residue may pose a serious risk to aquaculture, and the culture of in a low-salinity environment is a growing trend over the world. Here, we aimed to understand the combined effect of low salinity and sulfamethoxazole (SMZ) and florfenicol (FLO) antibiotics on . The growth performance, immune functions, antioxidant capacity and intestinal microbiota were investigated.

Aberrant ROS Served as an Acquired Vulnerability of Cisplatin-Resistant Lung Cancer.

Lung cancer has become a global health issue in recent decades. Approximately 80-85% of cases are non-small-cell lung cancer (NSCLC). Despite the high rate of resistance, cisplatin-base chemotherapy is still the main treatment for NSCLC patients.

Exploring the Longitudinal Relationship Between Lockdown Policy Stringency and Public Negative Emotions Among 120 Countries During the COVID-19 Pandemic: Mediating Role of Population Mobility.

Background: To limit the spread of COVID-19, governments worldwide have implemented a series of lockdown policies to restrict the social activities of people. Although scholars suggest that such policies may produce negative effects on public emotions, the existing research is limited because it only provides a cross-sectional snapshot of the effect of lockdown policies in small and local samples. Using large-scale longitudinal cross-country data, the current study aims to gain a better understanding of the dynamic effect of lockdown policies on public emotions and their underlying mechanisms.

The greener, the happier? The effects of greenspace on residents' happiness in contemporary urban China.

In recent years, research has begun to touch upon the associations between the natural environment and individuals' subjective wellbeing; however, whether such associations would vary among different groups of people remains under-studied. Using four waves (2010-2013) of data from the Chinese General Social Survey, we investigate the group-specific correlation between environment-specifically, greenspace exposure-and individuals' happiness in contemporary urban China. For this study, the normalized difference vegetation index at the county level is a proxy for greenspace exposure.

PM exposure and anxiety in China: evidence from the prefectures.

Background: Anxiety disorders are among the most common mental health concerns today. While numerous factors are known to affect anxiety disorders, the ways in which environmental factors aggravate or mitigate anxiety are not fully understood.

Methods: Baidu is the most widely used search engine in China, and a large amount of data on internet behavior indicates that anxiety is a growing concern.

The Association Between PM and Depression in China.

While China has been experiencing unprecedented economic growth, depression is becoming one of the most striking social and mental health problems in recent years. Such a paradox to progress may partially be due to the notoriously poor air quality of the country. To verify this argument, we constructed an index of the prevalence of depression (IPD) using internet search query volumes in Baidu to proxy the potential depression and examined how IPD is associated with PM, the major air pollutant in China.

Starvation-induced suppression of DAZAP1 by miR-10b integrates splicing control into TSC2-regulated oncogenic autophagy in esophageal squamous cell carcinoma.

Esophageal squamous cell carcinoma (ESCC) accounts for about 90% of all incident esophageal cancers, with a 5-year survival rate of < 20%. Autophagy is of particular importance in cancers; however, the detailed regulatory mechanisms of oncogenic autophagy in ESCC have not been fully elucidated. In the present study, we address how splicing control of is involved in mTOR-regulated oncogenic autophagy.

Migration status, emotional engagement, and social exclusion in Chinese schools.

Introduction: Since migration has become one of the pressing issues of our time, the school engagement of migrant children in the destination cities has drawn increasing scholarly attention. While most existing studies have focused on the cognitive and behavioral dimensions of school engagement of migrant children compared to local children, the emotional dimension has received less scholarly attention. Using a large-scale, national representative, school-level longitudinal survey data conducted in 2014 in China, this study examined the effect of migration status on children's emotional engagement in school.

Mapping Public Concerns of Electronic Cigarettes in China.

E-cigarettes have gained growing visibility in recent years. However, there lacks a panoramic image of e-cigarette concerns, particularly in low-income countries, such as China. Studying the public concern at a macro level may help reveal the development of the e-cigarette market, and potential health burden of a province as a whole, which is crucial for the policy regulation of the e-cigarette market, and for the allocation of medical resources in the future.

The Health Consequences of Social Mobility in Contemporary China.

Although numerous studies have shown the importance of an individual's socioeconomic status on his or her self-rated health status, less well-known is whether self-perceived class mobility, a measure highly correlated with an individual's de facto social class and past mobility experiences, affects self-rated health. In this paper, we attempt to fill the gap by examining how perception of class mobility is associated with self-rated health. Using eight waves of Chinese General Social Survey data spanning the years 2005 to 2015, we conducted an analysis at the micro (individual) level and the macro (provincial) level.

International visibility as determinants of foreign direct investment: An empirical study of Chinese Provinces.

While previous studies use economic and institutional variables to explain transnational investment operations, we argue that regionally-specific international visibility can significantly influence the investment decisions of foreign firms with spatial and temporal dynamics. Empirically, we extract the usage frequency of the names of all of the Chinese provinces in millions of English-language books from Google Books N-gram corpus to construct the index of international visibility as a proxy measurement of international prominence. Results from dynamic panel data analysis (1994-2004) using the Generalized Method of Moments demonstrate that the level of international visibility of a province has a positive effect on the inflows of foreign direct investments, controlling for a set of economic and institutional factors.

Using the Baidu Search Index to Predict the Incidence of HIV/AIDS in China.

Based on a panel of 30 provinces and a timeframe from January 2009 to December 2013, we estimate the association between monthly human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) incidence and the relevant Internet search query volumes in Baidu, the most widely used search engine among the Chinese. The pooled mean group (PMG) model show that the Baidu search index (BSI) positively predicts the increase in HIV/AIDS incidence, with a 1% increase in BSI associated with a 2.1% increase in HIV/AIDS incidence on average.

Laugh and grow fat: Happiness affects body mass index among Urban Chinese adults.

Previous studies have extensively examined the relationship between body mass index (BMI) and subjective well-being (SWB) but have mainly focused on the effects of BMI on SWB, leaving the question of whether BMI can be influenced by SWB largely neglected. In this study, we present the first empirical evidence on the effects of SWB on BMI among adults, using data combined from four waves of the Chinese General Social Survey (CGSS) (2010-2013). We find that, among urban Chinese adults, those who have a higher level of happiness tend to have higher BMI, after extensively controlling for a constellation of individual sociodemographic and health attributes.

Subjective well-being in the new China: religion, social capital, and social status.

We present the first nationally representative evidence on the relationship between religion and subjective well-being for the case of China. Research on Western societies tends to find a positive association between being religious and level of well-being. China provides an interesting critical case as the religious population is growing rapidly and the religious and socioeconomic environments are profoundly different from Western societies, implying different mechanisms might be at work.

Clinical and Virological Characteristics of Ebola Virus Disease Patients Treated With Favipiravir (T-705)-Sierra Leone, 2014.

Background:  During 2014-2015, an outbreak of Ebola virus disease (EVD) swept across parts of West Africa. No approved antiviral drugs are available for Ebola treatment currently.

Methods:  A retrospective clinical case series was performed for EVD patients in Sierra Leone-China Friendship Hospital.

Economic performance and public concerns about social class in twentieth-century books.

What is the association between macroeconomic conditions and public perceptions of social class? Applying a novel approach based on the Google Books N-gram corpus, this study addresses the relationship between public concerns about social class and economic conditions throughout the twentieth century. The usage of class-related words/phrases, or "literary references to class," in American English-language books is related to US economic performance and income inequality. The findings of this study demonstrate that economic conditions play a significant role in literary references to class throughout the century, whereas income inequality does not.

Application of the yeast-surface-display system for orally administered salmon calcitonin and safety assessment.

High manufacturing costs and oral delivery are the constraints in clinical application of calcitonin. We selected surface-displayed Saccharomyces cerevisiae as a low-cost and safe carrier for oral delivery of salmon calcitonin (sCT). The sCT DNA fragment, optimized according to the codon preference of S.

Anti-hypercalcemic effect of orally administered recombinant Saccharomyces cerevisiae expressing salmon calcitonin on hypercalcemic rats.

Oral delivery of salmon calcitonin (sCT) to rats via a recombinant Saccharomyces cerevisiae was assessed. A synthetic sCT gene was cloned and expressed in S. cerevisiae yAGA2-sCT.