MicroRNA-145 attenuates IL-6-induced enhancements of sensitivity to UVB irradiation by suppressing MyD88 in HaCaT cells.

MicroRNAs (miRNAs/miRs) play vital roles in various immune diseases including systemic lupus erythematosus (SLE). The current study aimed to assess the role of miR-145 in interleukin-6 (IL-6)-treated HaCaT cells under ultraviolet B (UVB) irradiation and further explore the potential regulatory mechanism. HaCaT cells were pretreated with IL-6 and then exposed to UVB to assess the effect of IL-6 on sensitivity of HaCaT cells to UVB irradiation.

MicroRNA-139-5p alleviates UVB-induced injuries by regulating TLR4 in si-IL-6-treated keratinocyte cells.

Lupus erythematosus (LE) is an autoimmune disease that is often exacerbated by ultraviolet B (UVB) irradiation. MicroRNAs (miRNAs) play vital roles in response to UVB damage to keratinocyte cells. Herein, our study aimed to explore the functions of miR-139-5p in UVB-induced injuries in keratinocyte cells.

[Behavioral characteristics of men who have sex with men with sadomasochism associated with bleeding].

Objective: To investigate the behavioral characteristics of men who have sex with men (MSM)with sadomasochism associated bleeding and to analyze the relationship with HIV/AIDS high risk behavior.

Methods: Using modified snowball sampling methods (target sampling methods) to carry out a cross-sectional study on persons with behavior of sadomasochism that associated with bleeding in MSM, using a valid questionnaire. Another control group without the related behavior was set up.