Relationship between glycemic variability and the incidence of postoperative atrial fibrillation following cardiac Surgery: A retrospective study from MIMIC-IV database.

Aims: This study aimed to explore the association between glycemic variability (GV) and postoperative atrial fibrillation (POAF) incidence.

Methods: In this retrospective study, we included patients undergoing cardiac surgeries. GV was calculated as the coefficient of variation of blood glucose and categorized into tertiles based on its distribution.

Comparative transcriptome analysis identified genes involved in ovarian development in Takifugu rubripes.

Ovarian development is a complex process involving multiple genes, but the molecular mechanisms underlying this process in Takifugu rubripes remain poorly understood. This study aimed to identify genes associated with ovarian development in T. rubripes and to investigate the regulatory mechanisms of oocyte maturation.

Efficacy of immune checkpoint inhibitors in pulmonary sarcomatoid carcinoma and predictive potential of mutated TP53.

Objective: Pulmonary sarcomatoid carcinoma (PSC) is a rare, heterogeneous subgroup of non-small cell lung cancer (NSCLC). Patients with advanced PSCs have poor survival due to resistance to chemotherapy and radiotherapy, and narrow access to targeted therapy. Immune checkpoint inhibitors (ICIs) offer new hope, whereas data on their effectiveness is limited.

Opposite effects of sevoflurane at high and low concentration on the airway inflammation in juvenile asthma rats: A TMT-based proteomics analysis study.

Background: The incidence of sevoflurane-related adverse respiratory events in children with asthma is notably high. During different phases of sevoflurane anesthesia, asthmatic children's airways are exposed to varying concentrations of the anesthetic. However, the specific effects of different concentrations of sevoflurane on the developing airways with asthmatic hyperreactivity have not been systematically studied.

Exercise electrocardiogram combined with cadmium zinc tellurium (CZT) cardiac-dedicated single photon emission computed tomography (SPECT) predicts coronary artery disease.

Aim: Coronary artery disease (CAD) is a primary cause of mortality, prompting ongoing research into noninvasive diagnostic modalities. This study aimed to evaluate the diagnostic efficacy of exercise electrocardiography testing (EET) combined with cadmium zinc tellurium cardiac-dedicated single photon emission computed tomography (CZT-SPECT) imaging for CAD.

Materials And Methods: CZT-SPECT and EET were examined in 124 patients aged 20-85 years, followed by coronary angiography to evaluate the sensitivity, specificity, positive predictive value, and negative predictive value of EET/CZT-SPECT alone and in combination.

The role of third component in coumarin-based all-small-molecule ternary organic solar cells with non-fullerene acceptor based on molecular stacking.

The power conversion efficiency (PCE) of ternary all-small-molecule organic solar cells (T-ASM-OSCs) differs significantly from that of the polymer systems (2 %), and the role of third component remains unclear. The electron donor of coumarin derivatives with simple structure and strong and broad light absorption has high PCE for T-ASM-OSCs composed of non-fullerene acceptors (Y6 and DBTBT-IC). Here, we calculated the electronic structure and interfacial properties of the binary C1-CN:Y6 and ternary C1-CN:Y6:DBTBT-IC systems using molecular dynamic (MD) simulations and density functional theory (DFT) to explore the role of the third component (DBTBT-IC).

Elevating sensory quality through a dual-acid preservation strategy in ready-to-eat crayfish (Procambarus clarkii).

This study presents a targeted dual-acid preservation strategy for ready-to-eat crayfish (Procambarus clarkii), integrating a blend of phytic and lactic acids to fortify key sensory attributes throughout the storage phase. The primary objective was to maintain the sensory attributes of the crayfish during a 30-day storage period under 40 °C. Our approach significantly bolstered color retention by suppressing Maillard reactions and lipid oxidation, thereby maintaining the product's visual allure.

Fibrous MoS/BiS/BiFeO ternary heterojunction boosts piezoelectric photocatalytic performance.

Photocatalytic removal of antibiotic such as ciprofloxacin from polluted water is of great value for eco-environment protection. To further enhance the piezoelectric effect in photocatalysis, we designed and synthesized a ternary heterojunction piezoelectric photocatalyst through uniformly loading MoS nanosheets onto BiFeO (BFO) nanofibers, namely MoS/BiS/BFO. Piezoresponse force microscopy and Kelvin probe force microscopy demonstrated its enhanced piezoelectric properties, showing a maximum amplitude displacement of 395.

An antibacterial and antioxidant rosmarinic acid hydrogel normalizes macrophage polarization to expedite diabetic wound healing.

The management of diabetic wounds (DW) is a significant challenge within the medical field. Effectively regulating the levels of reactive oxygen species (ROS) at the wound site and orchestrating the inflammatory response are effective strategies for DW treatment. In this study, a novel hydrogel was developed by cross-linking polyboronic acid-modified carboxymethyl chitosan with herbal active ingredient rosmarinic acid (RA), an active herbal ingredient, through dynamic boronic esters formation.

CpG islands: Features and distribution in the genomes of porcine parvovirus.

Porcine parvovirus disease is a reproductive disorder caused by the porcine parvovirus (PPV) in sows and is characterised by miscarriage, stillbirth and mummification in pregnant sows. Porcine parvovirus disease poses a significant threat to pork herds and seriously hinders healthy and sustainable development of the pig farming industry. Currently, there is no effective treatment for porcine parvovirus disease except for prevention and control measures.

Effects of air flow micro pulverized wheat bran dietary fiber on physicochemical, structural, and digestive properties of wheat starch.

The effects of wheat bran dietary fiber (WBDF) treated by air flow micro-pulverization on gelatinization, thermal, rheological, structural properties, and in vitro digestion of wheat starch (WS) were investigated. Different particle sizes of WBDF were obtained by conventional knife grinding and airflow micro-grinding. Compared with conventional knife grinding, the particle size of WBDF treated by air flow micro-pulverization decreased, the particle size distribution was concentrated at small particle sizes, the specific surface area increased, and the hydraulic and oil-holding power decreased, which was mainly related to the change of WBDF spatial structure and the increase of solubility.

Differential Response to Cisplatin between Co-cultured Cells and Pure Cultured Cells Based on Single-cell RNA Sequencing of Three-dimensional-cultured Breast Cancer Cells.

Objective: The current study aimed to develop an experimental approach for the direct co-culture of three-dimensional breast cancer cells using single-cell RNA sequencing (scRNA-seq).

Methods: The following four cell culture groups were established in the Matrigel matrix: the untreated Michigan Cancer Foundation (MCF)-7 cell culture group, the MCF-7 cell culture plus cisplatin group, the untreated co-culture group, and the cell co-culture plus cisplatin group. For cell co-culture, MCF-7 cells, human mammary fibroblasts, and human umbilical vein endothelial cells were mixed at a ratio of 1:1:1.

The Display between HPV Infection and Host Immunity in Cervical Cancer.

Most cervical cancers are related to the persistent infections of high-risk Human Papillomavirus (HPV) infections. Increasing evidence has witnessed the immunosuppressive effectiveness of HPV in the oncogenesis steps and progression steps. Here we review the immune response in HPV-related cervical malignancies and discuss the crosstalk between HPVs and the host immune response.

Tuning the Selectivity in the Nonoxidative Alkane Dehydrogenation Reaction by Potassium-Promoted Zeolite-Encapsulated Pt Catalysts.

The significance of the nonoxidative dehydrogenation of middle-chain alkanes into corresponding alkenes is increasing in the context of the world's declining demands on transportation fuels and the growing demand for chemicals and materials. The middle-chain alkenes derived from the dehydrogenation reaction can be transformed into value-added chemicals in downstream processes. Due to the presence of multiple potential reaction sites, the reaction mechanism of the dehydrogenation of middle-chain alkanes is more complicated than that in the dehydrogenation of light alkanes, and there are few prior studies on elucidating their detailed structure-reactivity relationship.

Structure-Based Design of "Head-to-Tail" Macrocyclic PROTACs.

Macrocyclization is a compelling strategy for conventional drug design for improving biological activity, target specificity, and metabolic stability, but it was rarely applied to the design of PROTACs possibly due to the mechanism and structural complexity. Herein, we report the rational design of the first series of "Head-to-Tail" macrocyclic PROTACs. The resulting molecule exhibited pronounced Brd4 protein degradation with low nM DC values while almost totally dismissing the "hook effect", which is a general character and common concern of a PROTAC, in multiple cancer cell lines.

Single-Cell Sequencing and Machine Learning Integration to Identify Candidate Biomarkers in Psoriasis: .

Background: Psoriasis represents a persistent, immune-driven inflammatory condition affecting the skin, characterized by a lack of well-established biologic treatments without adverse events. Consequently, the identification of novel targets and therapeutic agents remains a pressing priority in the field of psoriasis research.

Methods: We collected single-cell RNA sequencing (scRNA-seq) datasets and inferred T cell differentiation trajectories through pseudotime analysis.

Rapid and Large-Scale Synthesis of Chiral and Fluorescent Sulfur Quantum Dots for Intracellular Temperature Monitoring.

The large-scale preparation of fluorescent nanomaterials with laboratory-relevant chemical and optical properties will greatly forward their consumer market applications; however, it still remains challenging. In this work, a universal strategy was developed for the rapid and large-scale synthesis of fluorescent sulfur quantum dots that recently has drawn great attention because of their unique optical characteristics. From the fact that empty 3d orbitals of sulfide species are able to bind with lone-pair π electrons of the heteroatomic groups, many amino-group containing compounds, such as amino acid and polyethylenimine molecules, were exploited to synthesize sulfur quantum dots.

Prevalence and influencing factors of oral frailty in older adults: a systematic review and meta-analysis.

Objective: This study aimed to conduct a systematic review and meta-analysis, assessing the pooled prevalence and influencing factors of oral frailty in older people to assist healthcare professionals in enhancing their understanding of this condition and formulating efficient interventions.

Methods: This systematic review was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses Statement (PRISMA) guidelines. We searched PubMed, Web of Science, The Cochrane Library, Embase, CINAHL, ProQuest, the National Knowledge Infrastructure (CNKI), WAN FANG DATA, VIP Information, SinoMed and Scopus for literature published in English or Chinese from inception to June 19, 2024.

Examining the effects of psychological resilience and wellbeing on perceived stress and depressive symptoms among undergraduate nursing interns: testing a moderated mediation model.

Background: Perceived stress is recognized as a significant risk factor for depressive symptoms, while psychological resilience and wellbeing are considered crucial protective factors. However, the intricate relationships among these variables in undergraduate nursing interns remain largely unexplored. This study aims to investigate the mediating role of psychological resilience in the relationship between perceived stress and depressive symptoms, as well as the moderating influence of wellbeing on this mediation.

Origin, spread, and interspecies transmission of a dominant genotype of BJ/94 lineage H9N2 avian influenza viruses with increased threat.

The H9N2 subtype of avian influenza viruses (AIVs) is widely prevalent in poultry and wild birds globally, with occasional transmission to humans. In comparison to other H9N2 lineages, the BJ/94 lineage has raised more public health concerns; however, its evolutionary dynamics and transmission patterns remain poorly understood. In this study, we demonstrate that over three decades (1994-2023), BJ/94 lineage has undergone substantial expansion in its geographical distribution, interspecies transmission, and viral reassortment with other AIV subtypes, increasing associated public health risks.

MAFG-DT promotes prostate cancer bone metastasis through activation of the Wnt/β-catenin pathway.

Background: Prostate cancer (PCa) ranks as the second leading cause of cancer-related mortality among men. Long non-coding RNAs (lncRNAs) are known to play a regulatory role in the development of various human cancers. LncRNA MAFG-divergent transcript (MAFG-DT) was reported to play a crucial role in tumor progression of multiple human cancers, such as pancreatic cancer, colorectal cancer, bladder cancer, and gastric cancer.

Predicting distant metastasis of bladder cancer using multiple machine learning models: a study based on the SEER database with external validation.

Background And Purpose: Distant metastasis in bladder cancer is linked to poor prognosis and significant mortality. Machine learning (ML), a key area of artificial intelligence, has shown promise in the diagnosis, staging, and treatment of bladder cancer. This study aimed to employ various ML techniques to predict distant metastasis in patients with bladder cancer.

Age-related unstable transient states and imbalanced activation proportion of brain networks in people with autism spectrum disorder: A resting-state fMRI study using coactivation pattern analyses.

The atypical static brain functions related to the executive control network (ECN), default mode network (DMN), and salience network (SN) in people with autism spectrum disorder (ASD) has been widely reported. However, their transient functions in ASD are not clear. We aim to identify transient network states (TNSs) using coactivation pattern (CAP) analysis to characterize the age-related atypical transient functions in ASD.

S100A8 promotes tumor progression by inducing phenotypic polarization of microglia through the TLR4/IL-10 signaling pathway in glioma.

Background: S100A8 is a member of the S100 protein family and plays a pivotal role in regulating inflammation and tumor progression. This study aimed to comprehensively assess the expression patterns and functional roles of S100A8 in glioma progression.

Methods: Glioma tissues were collected from 98 patients who underwent surgical treatment at Fudan University Shanghai Cancer Center.

Sediment provenance of Late Carboniferous-Early Triassic in the Puyang area, Eastern North China Craton.

To reveal the stratigraphic age of the Shiqianfeng Formation in the eastern continental basin of the North China Craton and the provenance of its sediments from the Late Carboniferous to the Early Triassic, six sandstone samples from the Puyang area were selected for zircon U-Pb dating. The result show that the Shiqianfeng Formation in the eastern North China Craton belongs to the Early Triassic. According to the age clusters of six samples, considering the regional geological setting and the distribution of zircon ages in the potential provenance area, it can be inferred that the Inner Mongolia Paleo-uplift provided continuous provenance supply for the study area during the Late Carboniferous-Early Triassic.