Sinulariapeptide F, a new peptide from culture broth of marine-derived fungus Simplicillium sp. SCSIO 41222.

One new compound named sinulariapeptide F (1) together with one known butyrolactone (2) and seven known peptides (3-9) were isolated from the fungus Simplicillium sp. SCSIO 41222. Their structures and absolute configurations were established using HRESIMS, NMR spectroscopy (H, C, HSQC, HMBC) and marfey's method.

Antimicrobial Isochroman-Derived Atropo-Diastereomeric Dimers from Penicillium Steckii SCISO 41228.

A pair of unidentified atropo-diastereomeric dimers, penicisteckins G (1) and H (2), and twelve known compounds (3-16) were isolated from the marine coral-derived fungus Penicillium steckii SCISO 41228. Their structures including the absolute configuration were determined by HR-ESI-MS, ECD, 1D-, and 2D-NMR spectra. Compounds 1 and 2 exhibited moderate antibacterial activity against most tested pathogenic strains, especially for methicillin-resistant Staphyloccocus aureus (MASA) and Micrococcus luteus, with MIC values of 4.

Novel Metabolites from the Marine-Derived Fungus sp. SCSIO41203 Show Promising In Vitro Antitumor Activity as Methuosis Inducers in PC-3 Cells.

Two new cytochalasin derivatives, peniotrinins A () and B (), three new citrinin derivatives, peniotrinins C-E (, , ), and one new tetramic acid derivative, peniotrinin F (), along with nine structurally related known compounds, were isolated from the solid culture of sp. SCSIO41203. Their structures, including the absolute configurations of their stereogenic carbons, were fully elucidated based on spectroscopic analysis, quantum chemical calculations, and the calculated ECD.

A new indole alkaloid from sp. SCSIO41205.

A new indole compound, -hydroxy--(2-(1-hydroxy-2-methoxy-1-indol-3-yl)ethyl acetamide (), together with four known compounds, -(2-(1-indol-3-yl)ethylacetamide (), -acetylamicoumacin C (), -(2-phenylethyl)acetamide (), and (2 ,3)-1-(4-hydroxyphenyl)butane-2,3-diol () were isolated from sp. SCSIO41205. Their structures were established by detailed analysis of the NMR and HR-ESI-MS data.

Dankasterone A induces prostate cancer cell death by inducing oxidative stress.

Oxidative stress plays a dual role in tumor survival, either promoting tumor development or killing tumor cells under different conditions. Dankasterone A is a secondary metabolite derived from the fungus Talaromyces purpurogenu. It showed good potential in a screen for anti-prostate cancer compounds.

A torus source and its application for non-primary radiation evaluation.

. Non-primary radiation doses to normal tissues from proton therapy may be associated with an increased risk of secondary malignancies, particularly in long-term survivors. Thus, a systematic method to evaluate if the dose level of non-primary radiation meets the IEC standard requirements is needed.

Monitoring the Micro-Structural Evolution Mechanism of Next-Generation Ultra-High-Energy All-Nitrogen Materials: A Molecular Dynamic Study.

Micro-structural evolution mechanisms of next-generation ultra-high-energy all-nitrogen materials under the extreme conditions of high temperature coupled with high pressure were revealed by state-of-the-art ab initio molecular dynamics studies based on highest-nitrogen-content energetic material 2,2'-azobis(5-azidotetrazole). The results indicate that there are three primary initial uni-molecular decomposition pathways, namely, tetrazole ring opening, azido group elimination, and the breaking of the N-N bond between the azo group and azidotetrazole. In complicated global decomposition reactions, there exists the formation of nitrogen-rich clusters and all-nitrogen species.

Bioactive secondary metabolites isolated from the soft coral derived sp. SCSIO 41038.

Chemical investigation of the sp. SCSIO 41038 led to the isolation and characterization of one new cyclopiazonic acid-type alkaloid, speradine I (), and one new phloroglucinol derivative, speradine J (), along with 13 known compounds. Their structures were determined on the basis of extensive spectroscopic analysis, and by a comparison with data from the literature.

Effects of Europium Complex on Thermal and Photoluminescence Properties of Polyurethane-Europium Materials.

A europium complex with double bonds was synthesized with crotonic acid as the ligand and a europium ion as the center ion. Then, the obtained europium complex was added to synthesized poly(urethane-acrylate) macromonomers to prepare the bonded polyurethane-europium materials by the polymerization of the double bonds in the complex and the poly(urethane-acrylate) macromonomers. The prepared polyurethane-europium materials had high transparency, good thermal stability and good fluorescence.

Phase transition-induced initial decomposition of nitrogen-rich binary CN compound 2,2'-azobis(5-azidotetrazole) and its precursor 2-amino-5-azidotetrazole tetrazole ring opening under external electric fields: a comparative DFT-D study.

A comparative DFT-D study was performed to investigate the external electric field-induced crystal structures, electronic features, Hirshfeld surfaces, vibrational properties and initial decomposition mechanisms of nitrogen-rich binary CN compound 2,2'-azobis(5-azidotetrazole) (CN) and its precursor 2-amino-5-azidotetrazole (CHN). The results show that there exist phase transitions at the critical points of 0.006 a.

LncRNA NR120519 Blocks KRT17 to Promote Cell Proliferation and Migration in Hypopharyngeal Squamous Carcinoma.

Background: Hypopharyngeal carcinoma is the worst type of head and neck squamous cell carcinoma. It is necessary to identify the key molecular targets related to the carcinogenesis and development of hypopharyngeal carcinoma.

Methods: Differentially expressed lncRNAs in hypopharyngeal carcinoma were selected by microarray, and lncRNA-associated proteins were found by RIP assay.

Phase transition induced by an external electric field as a buffer to facilitate the initial decomposition of a series of catenated nitrogen energetic systems: a first-principles study.

The effect of an external electric field on the crystal and electronic structures, Hirshfeld surfaces, hydrogen-bonding network, mechanical properties, vibrational properties and initial decomposition mechanisms of a series of chain-catenated N ( = 4, 8, 10) energetic crystals was investigated a first-principles study. The results indicate that the response behaviors to the external electric field show a great dependence on the nitrogen chain length and the intensity of the external electric field. The critical points of the phase transition were found and are embodied in various properties of all the compounds.

Diversified Chaetoglobosins from the Marine-Derived Fungus sp. SCSIO41202.

Two undescribed cytochalasins, emeriglobosins A () and B (), together with nine previously reported analogues (-) and two known tetramic acid derivatives (, ) were isolated from the solid culture of sp. SCSIO41202. Their structures, including the absolute configurations of their stereogenic carbons, were fully elucidated based on spectroscopic analysis and the calculated ECD.

Azaphilones and Meroterpenoids from the Soft Coral-Derived Fungus Penicillium glabrum glmu003.

Two new azaphilone compounds, daldinins G (1) and H (2), together with nine known compounds daldinin D (3), sargassopenilline B (4), austalide V (5), austalide K (6), austalide P (7), austalide P acid (8), austalide H (9), 13-O-deacetyaustalide I (10), and 17-O-demethylaustalide B (11), were isolated from the soft coral-derived fungus Penicillium glabrum glmu003. The new structures of 1 and 2 were elucidated on the basis of 1D and 2D NMR, mass spectra, and electronic circular dichroism (ECD) data analysis. Compound 5 showed weak inhibitory activity against pancreatic lipase (PL) with IC value of 23.

Arthriniumsteroids A-D, four new steroids from the soft coral-derived fungus Simplicillium lanosoniveum SCSIO41212.

Four new steroids derivatives, namely arthriniumsteroids A - D (1-4), together with two known compounds, were isolated from the soft coral-derived fungus Simplicillium lanosoniveum SCSIO41212. Their structures were elucidated by spectroscopic analysis and by comparison with those reported in the literature. The absolute configuration of 2 was confirmed by single-crystal X-ray diffraction.

Ellagitannins and Oligomeric Proanthocyanidins of Three Polygonaceous Plants.

The aim of this study was to characterize hydrolyzable tannins in Polygonaceous plants, as only a few plants have previously been reported to contain ellagitannins. From , a new hydrolyzable tannin called persicarianin was isolated and characterized to be 3--galloyl-4,6-()-dehydrohexahydroxydiphenoyl-d-glucose. Interestingly, acid hydrolysis of this compound afforded ellagic acid, despite the absence of a hexahydroxydiphenoyl group.

Structurally diverse polyketides and phenylspirodrimanes from the soft coral-associated fungus Stachybotrys chartarum SCSIO41201.

Four undescribed polyketide derivatives, named arthproliferins A-D (1-4), and one undescribed phenylspirodrimane derivative, named arthproliferin E (7), along with 11 known metabolites (5, 6, 8-16) were isolated from the soft coral-associated fungus Stachybotrys chartarum SCSIO41201. Their structures were determined through spectroscopic methods, X-ray crystallography, and ECD analysis. Compounds 1 and 3-15 were evaluated for their cytotoxic, and antibacterial activities.

Two new bioactive polyphenols from the soft coral-derived fungus sp. SCSIO 041201.

Two new polyphenols, talaversatilis A () and B (), together with fifteen known compounds (-) were isolated from the extract of the culture broth of a soft coral-derived fungus sp. SCSIO 041201. The structures of these compounds were elucidated by the extensive analyses of spectroscopic data and by comparison with the reported literature.

Synthesis, Morphology, and Luminescence Properties of Poly(urethane-acrylate) Nanowires Bonding with the Eu(III) Complex.

Photoluminescent poly(urethane-acrylate) (PUA) nanowires are designed and synthesized through copolymerization of a presynthesized-europium (Eu) complex with active vinyl groups and a vinyl functionalized PUA macromonomer matrix, initiated by azobisisobutyronitrile. This procedure provides a method to prepare PUA-Eu nanowires through in situ polymerization. Based on this, a series of PUA-Eu nanowires with diameters of 80-300 nm are successfully obtained in templates of anodized aluminum oxide by in situ polymerization.

The proinflammatory cytokines IL-1β and TNF-α modulate corneal epithelial wound healing through p16 suppressing STAT3 activity.

The proinflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) are involved in the corneal inflammatory response and wound healing following corneal injuries. However, the mechanism by which proinflammatory cytokines modulate corneal epithelial wound healing remains unclear. In this study, we found that IL-1β or TNF-α was transiently elevated during corneal epithelial wound healing in mice.

Four new steroids from the marine soft coral-derived fungus Penicillium sp. SCSIO41201.

Penicildiones A-D (1-4), four new steroids derivatives together with three known compounds including 16α-methylpregna-17α,19-dihydroxy-(9,11)-epoxy-4-ene-3,18-dione-20-acetoxy (5), stachybotrylactone B (6) and stachybotrin (7) were isolated from the soft coral-derived fungus Penicillium sp. SCSIO41201, cultured in the 1% NaCl PDB substrate. Their structures were determined through spectroscopic methods and X-ray crystallography.

Retraction Note: Inhibition of airway inflammation in a cockroach allergen model of asthma by agonists of miRNA-33b.

This article has been retracted.

A new griseofulvin derivative from a soft coral-derived fungus sp. SCSIO41208.

A new griseofulvin derivative, eupenigriseofulvin (), together with six known compounds, griseofulvin (), dechlorogriseofluvin (), dechloroisogriseofulvin (), trichopyrone (), 2-(4-hydroxyphenyl)-ethanol (), and 1-phenylethane-1,2-diol (), were isolated from the EtOAc extract of sp. SCSIO41208. The structures of these compounds were elucidated by spectroscopic methods including NMR and mass spectrometry.