TOPS-speed complex-valued convolutional accelerator for feature extraction and inference.

Complex-valued neural networks process both amplitude and phase information, in contrast to conventional artificial neural networks, achieving additive capabilities in recognizing phase-sensitive data inherent in wave-related phenomena. The ever-increasing data capacity and network scale place substantial demands on underlying computing hardware. In parallel with the successes and extensive efforts made in electronics, optical neuromorphic hardware is promising to achieve ultra-high computing performances due to its inherent analog architecture and wide bandwidth.

The function of the inter-alpha-trypsin inhibitors in the development of disease.

Through the formation of covalent connections with hyaluronic acid (HA), the inter-α-trypsin inhibitor (IαI) family collaborates to preserve the stability of the extracellular matrix (ECM). The five distinct homologous heavy chains (ITIH) and one type of light chain make up the IαI family. ITIH alone or in combination with bikunin (BK) has been proven to have important impacts in a number of earlier investigations.

Photonic multiplexing techniques for neuromorphic computing.

The simultaneous advances in artificial neural networks and photonic integration technologies have spurred extensive research in optical computing and optical neural networks (ONNs). The potential to simultaneously exploit multiple physical dimensions of time, wavelength and space give ONNs the ability to achieve computing operations with high parallelism and large-data throughput. Different photonic multiplexing techniques based on these multiple degrees of freedom have enabled ONNs with large-scale interconnectivity and linear computing functions.

Effective-compounds of Jinshui Huanxian formula ameliorates fibroblast activation in pulmonary fibrosis by inhibiting the activation of mTOR signaling.

Background: Jinshui Huanxian formula (JHF) ameliorates idiopathic pulmonary fibrosis patients. Active compounds, including icariin, isoliquiritigenin, nobiletin, peimine, and paeoniflorin, deriving from JHF were combined as effective-component compatibility ECC of JHF II (ECC-JHF II), which is an effective therapeutic strategy for pulmonary fibrosis (PF) induced by bleomycin (BLM) in rats.

Purpose: This study aimed to explore the underlying mechanism of ECC-JHF II on pulmonary fibrosis.

Yangqing Chenfei formula attenuates silica-induced pulmonary fibrosis by suppressing activation of fibroblast via regulating PI3K/AKT, JAK/STAT, and Wnt signaling pathway.

Background: Yangqing Chenfei formula (YCF) has been demonstrated its clinical efficiency on silicosis patients. However, the effect of YCF against silicotic fibrosis and its mechanism remain unclear.

Purpose: This study is aimed to investigate active compounds and molecular mechanism of YCF in treating silicosis.

[Digoxin alleviates pulmonary fibrosis by regulating phosphatidylinositol-3-kinase/Akt signaling through inhibiting the activation of fibroblast: an in vivo and in vitro experiment].

Objective: To investigate the effect of digoxin on bleomycin-induced pulmonary fibrosis in mice, and investigate its possible mechanism through in vitro and in vivo experiments.

Methods: (1) In vivo experiment: 60 C57/BL6J mice were randomly divided into control group, pulmonary fibrosis model group (model group), pirfenidone (300 mg/kg) group, digoxin 1.0 mg/kg and 0.

Synthesis and reactivity of a μ-1,2-dinitrogen dinickel(II) complex with a C-H activated silaamidinate pincer ligand.

Reaction of the silaamidinate nickel bromide LSi(NAr)NiBrLi(thf)(OEt) (L = PhC(NBu), Ar = 2,6-iPrCH, 1) with NaHBEt led to intramolecular C-H activation with the formation of the μ-1,2-dinitrogen dinickel pincer complex [LSi(NAr)(NAr)Ni](μ-1,2-N) (Ar = 2-C(CH)-6-iPrCH, 2). Single-crystal X-ray diffraction analysis of 2 disclosed a square planar Ni(II) atom bridged by N. Reaction of 2 with carbon monoxide and 2,6-dimethylphenyl isocyanide yielded square planar carbonyl and isocyanide complexes 3 and 4 with release of N.

Broadband dual-channel channelizer based on a microwave photonic power tunable image rejection down-conversion.

Radiofrequency (RF) channelization has potential high frequency and wideband advantages in frequency-domain channel segmentation and down-conversion reception. In this paper, we propose a compact dual-channel channelizer that can process high-frequency wideband signals. It uses double-polarization double-sideband electro-optic modulation and Hartley structure photoelectric conversion to realize down-conversion channelization of the high-frequency wideband signal.

Peimine ameliorates pulmonary fibrosis via the inhibition of M2-type macrophage polarization through the suppression of P38/Akt/STAT6 signals.

Peimine, a bioactive substance isolated from Chinese medicine Fritillaria, can potentially suppress pulmonary fibrosis (PF); however, its therapeutic mechanism remains unclear. Recent evidence suggests the participation of M2-type macrophages in the pathogenesis of PF. The present study aimed to investigate the effect of peimine on a bleomycin (BLM)-induced PF rat model and the underlying mechanism of this effect.

Identification of the active compounds and functional mechanisms of Jinshui Huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry with network pharmacology.

Background: Jinshui Huanxian formula (JHF), a traditional Chinese medicine (TCM), has been demonstrated to attenuate idiopathic pulmonary fibrosis (IPF). The active compounds and underlying mechanisms of JHF, however, are unclear.

Purpose: The purpose of This study was to aimed to identify the active compounds and pharmacological mechanism of JHF by integrating serum pharmacochemistry with a network pharmacology strategy.

Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling.

Background And Purpose: The M2 polarization of macrophages substantially contributes to the progression of pulmonary fibrosis (PF). Effective-compound combination (ECC), which is composed of isoliquiritigenin, icariin, nobiletin, peimine, and paeoniflorin, ameliorated bleomycin-induced PF in rats. Hence, we investigated the anti-PF mechanism of ECC with a focus on the suppression of M2 polarization in macrophages in vivo and in vitro.

Generation of rotational orbital angular momentum beams in the radio frequency based on an optical-controlled circular antenna array.

The orbital angular momentum (OAM) has been widely used in the wireless short-range communication system, but for long-distance communication, the huge difficulty of beam receiving is a great challenge. In this paper, to overcome this challenge, a generation system of radio-frequency rotational orbital angular momentum (RF-ROAM) beams based on an optical-controlled circular antenna array (CAA) is proposed. The ROAM beam is an OAM beam rotating at a certain speed around the beam axis.

Analog radio of fiber link of 2-Gbaud OOK/BPSK radio frequency-orbital angular momentum beam transmission over 19.4 km.

The 5G mobile communication system provides ultrareliable, low-latency communications at up to 10 Gbps. However, the scale and power consumption of 5G is tremendous owing to a large number of antenna drivers required by the massive multiple-input multiple-output technique. The 6G system will require an architectural paradigm shift to resolve this problem.

A pharmacological approach to study the active compounds in Jinshui Huanxian formula in treatment of pulmonary fibrosis.

Objective: To study the active compounds in Jinshui Huanxian formula in the treatment of pulmonary fibrosis with a pharmacological approach.

Methods: A systems pharmacology model, incorporating active compounds and targets prediction, and herbal-compound-target-disease network analysis, was established to predict the active substances and therapeutic mechanisms of Jinshui Huanxian formula. All compounds from the herbs of Jinshui Huanxian formula were obtained from drug database and the literature.

Chromatic dispersion immune microwave photonic phase shifter based on double-sideband modulation.

A chromatic dispersion (CD) immune microwave photonic phase shifter (MPPS) based on double-sideband (DSB) modulation is proposed and demonstrated. An optical spectrum processor introduces the phase shift to the MPPS. The DSB signals along two orthogonal polarizations are demodulated to two RF signals with both quadrature amplitude and phase items, transferring the CD-induced power fading to the phase item of the synthetic RF signals.

Photonic generation of background-free binary and quaternary phase-coded microwave pulses based on vector sum.

A photonic microwave phase-coded pulse generator is proposed and experimentally demonstrated based on the principle of vector sum. The key component of the proposed pulse generator is an integrated polarization-division multiplexing Mach-Zehnder modulator (PDM-MZM) and a 90° hybrid coupler. By properly setting the data sequences applied to the specially biased PDM-MZM, binary and quaternary phase-coded microwave pulses (PCMPs) that are free from the background signals can be generated.

Equivalent photonic switch for microwave frequency shift keying signal generation.

A photonic microwave frequency shift keying (FSK) signal generator is proposed and experimentally demonstrated based on an equivalent photonic switch (EPS). The EPS is constructed using a polarization-multiplexing dual-drive Mach-Zehnder modulator (PM-DMZM). By properly controlling the data sequences and RF signals applied to the PM-DMZM, microwave FSK signals with flexible frequency intervals can be obtained.

Broadband chromatic-dispersion-induced power-fading compensation for radio-over-fiber links based on Hilbert transform.

A Hilbert-transform-based broadband chromatic dispersion (CD) compensation scheme for radio-over-fiber links is proposed and experimentally demonstrated. By constructing a Hilbert transform path, CD-induced phase shifts, which initially lead to periodic power fading of the output RF signals, are transferred to the phases of the RF signals. As a result, the powers of the output RF signals are free from the effect of CD in a broadband frequency range.

An arene-tethered silylene ligand enabling reversible dinitrogen binding to iron and catalytic silylation.

An arene-tethered silylene ligand, L (L = PhC(tBuN)2SiCH2C(tBu)NAr, Ar = 2,6-iPr2C6H3), allowed the synthesis of three-coordinate Fe(ii) silylamido and piano-stool Fe(0) dinitrogen complexes LFe[N(SiMe3)2]2 (3) and LFe-N2 (4), which not only exhibit interesting bonding but also enabled the catalytic silylation of N2 to yield N(SiMe3)3 under 1 atm of N2 at room temperature with high TONs.

A Chinese Herbal Formula Ameliorates Pulmonary Fibrosis by Inhibiting Oxidative Stress via Upregulating Nrf2.

This study aimed to explore the protective effects of a Chinese herbal formula, Jinshui Huanxian formula (JHF), on experimental pulmonary fibrosis and its underlying mechanisms. After being treated with single dose of bleomycin (5 mg/kg) intratracheally, rats were orally administered with JHF and pirfenidone from day 1 to 42, then sacrificed at 7, 14, 28, or 42 days post-bleomycin instillation. JHF ameliorated bleomycin-induced pathological changes, collagen deposition in the rat lung and recovered pulmonary function at different days post-bleomycin instillation.

Long-Term Effects of TCM Yangqing Kangxian Formula on Bleomycin-Induced Pulmonary Fibrosis in Rats via Regulating Nuclear Factor-B Signaling.

Objective: We aimed to evaluate the therapeutic effects and long-term effects of YKF and dissect the potential mechanisms.

Materials And Methods: IPF rats were given YKF, prednisone, or pirfenidone, respectively, from day 1 to day 42, followed by a 28-day nonintervention interval through day 70. Forced vital capacity (FVC), histopathology, hydroxyproline (HYP) contents, lung coefficient, blood inflammatory cell populations, inflammatory cytokine levels of the lung tissues, and the expression of proteins involved in nuclear factor- (NF-) B signaling pathway were evaluated on days 7, 14, 28, 42, and 70.

Effect of Comprehensive Therapy based on Chinese Medicine Patterns on Self-Efficacy and Effectiveness Satisfaction in Chronic Obstructive Pulmonary Disease Patients.

Objective: To evaluate the effect of comprehensive therapy based on Chinese medicine (CM) patterns on self-efficacy and satisfaction with its effectiveness in patients with chronic obstructive pulmonary disease (COPD).

Methods: A total of 216 patients were randomly divided into the trial group (n =108) and the control group (n=108) based on the stratified and block randomization design. Patients in the trial group were treated with conventional Western medicine combined with Bufei Jianpi Granules (), Bufei Yishen Granules (), and Yiqi Zishen Granules () according to the CM patterns respectively, and patients in the control group were treated with conventional Western medicine.

Integrating 3-omics data analyze rat lung tissue of COPD states and medical intervention by delineation of molecular and pathway alterations.

Chronic obstructive pulmonary disease (COPD) is a serious health problem. However, the molecular pathogenesis of COPD remains unknown. Here, we explored the molecular effects of cigarette smoke and bacterial infection in lung tissues of COPD rats.

Cobalt-Catalyzed Regioselective Borylation of Arenes: N-Heterocyclic Silylene as an Electron Donor in the Metal-Mediated Activation of C-H Bonds.

C-H Borylation of arenes has been a subject of great interest recently because of its atom-economy and the wide applicability of borylated products in value-added synthesis. A new bis(silylene)cobalt(II) complex bearing a bis(N-heterocyclic silylene)-pyridine pincer ligand (SiNSi) has been synthesized and structurally characterized. It enabled the regioselective catalytic C-H borylation of pyridines, furans, and fluorinated arenes.

Effectiveness and safety of traditional Chinese medicine on stable chronic obstructive pulmonary disease: A systematic review and meta-analysis.

Objective: This study was intended to evaluate the efficacy and safety of Traditional Chinese Medicine (TCM) on stable chronic obstructive pulmonary disease (COPD).

Method: A systematic review was conducted of clinical trials that compared TCM plus conventional medicine treatment versus conventional medicine treatment alone. Randomized controlled trials (RCTs) of clinical therapeutic studies on COPD by TCM were included.