Mogrol Regulates the Expression of ATPase Na+/K+ Transport Subunit 3, Inhibits Cardiomyocyte Apoptosis, and Plays a Protective Role Against Myocardial Infarction.

Background: With the advancements in medical technology, the death rate from myocardial infarction (MI), a prevalent heart illness, has gradually decreased; however, treatment hurdles and diagnostic issues remain. Mogrol is a naturally occurring plant extract with specific biological activities such as antioxidant, anti-inflammatory, antitumor, and hypoglycemic effects. These biological activities make it a potential therapeutic drug or research subject; however, its function in MI remains unclear.

Odor induced functional connectivity alteration of POC-anterior frontal cortex-medial temporal cortex in patients with mild cognitive impairment.

Background: Mild cognitive impairment (MCI) is associated with an increased risk of dementia in older adults. Olfactory impairment may indicate prodromal dementia, yet its underlying mechanisms are not fully understood. This study aimed to investigate the alterations in functional connectivity (FC) of odor-induced olfactory neural circuits in MCI patients.

Two New Species (Asteraceae: Pertyoideae) From Southeast China: Based on Morphological Characters and Phylogenetic Evidence.

Two new species of (Asteraceae: Pertyoideae), X.X.Su and S.

Efficacy and safety of azelastine hydrochloride and fluticasone propionate nasal spray in treating allergic rhinitis: A randomized controlled trial.

Background: MP-AzeFlu (Dymista; Meda Pharma GmbH & Co., KG), a formulation combining azelastine hydrochloride and fluticasone propionate in a single spray, is superior to fluticasone propionate alone in relieving symptoms and improving the quality of life of patients with allergic rhinitis.

Objectives: In this study, we evaluated whether the effect of AzeFlu, a generic drug manufactured from China, is equivalent to that of MP-AzeFlu.

Factors that influence participation in physical activity in Chinese teenagers: perspective of school educators and parents in respect of the social ecology model.

Introduction: The objective of this study was to explore the viewpoints of parents, teachers, and administrators on the factors influencing adolescent physical activity in China.

Methods: The study employed semi-structured interviews with school teachers, school principals, government officers, and parents. Twenty-five participants were recruited from Jiangsu Province, China, and completed the interview.

Supercritical CO Activation Enables an Exceptional Methanol Synthesis Activity Over the Industrial Cu/ZnO/AlO Catalyst.

The ternary Cu/ZnO/AlO catalyst is widely used in the industry for renewable methanol synthesis. The tenuous trade-off between the strong metal-support interaction (SMSI)-induced Cu-ZnO interface and the accessible Cu surface strongly affects the activity of the final catalyst. Successes in the control of oxide migration on adsorbate-induced SMSI catalysts have motivated this to develop a supercritical CO activation strategy to synchronously perfect the Cu-O-Zn interface and Cu-Cu surface sites through the manipulation of the adsorbate diffusion kinetics, which involves OCH and "side-on" fixed CO species.

Biological Functions and Therapeutic Potential of UBE2T in Human Cancer.

The ubiquitin-proteasome system is a fundamental regulatory mechanism that governs protein stability and intracellular signaling in eukaryotic cells. This system relies on a coordinated cascade of enzymatic activities involving activating enzymes, conjugating enzymes, and ligases to assemble distinct ubiquitin signals. These signals are subsequently edited, removed, or interpreted by deubiquitinases and ubiquitin-binding proteins.

Knockdown of FKBP12.6 may Cause Bladder Dysfunction in Mice by Affecting IP3R/TRPM4 Function.

Background: FKBP12.6 is a crucial calcium regulatory molecule involved in the regulation of bladder excitatory contraction. This study employed FKBP12.

Realizing Intrinsically Ultralow and Glass-Like Thermal Transport via Chemical Bonding Engineering.

Crystals exhibiting glass-like and low lattice thermal conductivity ( ) are not only scientifically intriguing but also practically valuable in various applications, including thermal barrier coatings, thermoelectric energy conversion, and thermal management. However, such unusual are typically observed only in compounds containing heavy elements, with large unit cells, or at high temperatures. In this study, chemical bonding principles are utilized to weaken the Ag-Ag bonds and enhance lattice anharmonicity.

Relacorilant plus nab-paclitaxel for recurrent, platinum-resistant ovarian cancer: a cost-effectiveness study.

Objective: The phase 2, open-label, randomized, 3-arm study (NCT03776812) found that intermittently dosed relacorilant + nab-paclitaxel improved progression-free survival, duration of response, and overall survival compared with nab-paclitaxel monotherapy with minimal additional toxicity. This study analyzed the cost-effectiveness of intermittent relacorilant + nab-paclitaxel (IN), continuous relacorilant + nab-paclitaxel (CN) and nab-paclitaxel monotherapy (N) from the payer's perspective over a 5-year time horizon.

Methods: The health outcome is expressed in quality-adjusted life years (QALYs).

Customized Solvation Structures for Long-Term Stable Lithium Metal Batteries.

Lithium metal batteries (LMBs) suffer from severe lithium dendrite growth and side reactions in conventional carbonate electrolytes, which are characterized by low coulombic efficiency and poor cycling stability, and electrolyte engineering is an effective method for increasing the reversibility of lithium anodes. Herein, the solubility of lithium nitrate (LiNO), which is almost insoluble in carbonate electrolyte, is improved by adding zinc trifluoroacetate (Zn(TFA)), and a competitive solvation structure is constructed, forming an anion-enriched Li solvation structure, which is conducive to the formation of stable SEI and effectively inhibits adverse side reactions. The lithium metal anode exhibits uniform lithium deposition and extended cycle life, with high reversibility over plating/stripping for 640 h.

Cardiac Organoid Model Inspired Micro-Robot Smart Patch to Treat Myocardial Infarction.

Post-myocardial infarction (MI), the rapid decrease in pH triggers myocardial cell acidosis, which compromises the therapeutic efficacy of exosomes in MI. The groundbreaking research in the human cardiac organoid MI model suggests that exosomes, when paired with pH adjustment, dramatically reduce cardiomyocyte mortality while maintaining their proliferative potential, underscoring the importance of pH regulation in myocardial preservation. Micro-robot mounted micro-needle (MN) patch is thus proposed, targeting MI-acidic microenvironmet, to deliver exosomes into deep injured tissue.

Silk Nonwoven Fabric-Based Dressing with Antibacterial and ROS-Scavenging Properties for Modulating Wound Microenvironment and Promoting Diabetic Wound Healing.

The microenvironment of diabetic wounds is exceptionally complex, characterized notably by persistent bacterial infections and the excessive production of reactive oxygen species (ROS). Traditional treatment methods often fall short of achieving ideal results. Consequently, there is an urgent need to develop and implement more advanced and efficient treatment strategies to effectively address the complexity and recalcitrance of diabetic wounds.

From Dry to Wet, the Nature Inspired Strong Attachment Surfaces and Their Medical Applications.

Strong attachment in complicated human body environments is of great importance for precision medicine especially with the rapid growth of minimal invasive surgery and flexible electronics. Natural organisms with highly evolved feet or claws can easily climb in complex environments from dry to wet and even underwater, providing significant inspiration for strong attachment research. This review summarizes the strong attachment behaviors of natural creatures in varied environments such as the gecko, tree frog, and octopus.

FOXA2 Loss in TGF-β1-Induced EMT Suppresses Bisecting-GlcNAc N-Glycan Synthesis in Lung Adenocarcinoma.

Glycosylation, a major posttranslational modification (PTM), is often dysregulated in cancer due to altered glycosyltransferase activity. Studies have shown specific changes in glycan structures associated with epithelial-mesenchymal transition (EMT) in cancer cells. However, the specific mechanism by which glycosyltransferases contribute to EMT remains unclear.

Primary Renal Neuroendocrine Tumor Demonstrated on 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT.

Primary renal neuroendocrine tumors are very rare. Herein, we report a case of imaging findings of a renal neuroendocrine tumor in a 36-year-old man. On 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT, it presented as a renal soft tissue mass with intense FAPI uptake (SUVmax: 20.

Enhanced Soil Emissions of Reactive Nitrogen Gases by Fertilization and Their Impacts on Secondary Air Pollution in Eastern China.

Nitrogen fertilizer application is accompanied by intense release of multiple reactive nitrogen (Nr) gases such as nitrous acid (HONO), ammonia (NH), and nitric oxide (NO) from the soil, influencing atmospheric chemistry and air pollution. In current emission inventories, postfertilization soil emissions are poorly characterized due to inaccurate identification of fertilization timing and location. Moreover, pre-existing studies predominantly focus on individual Nr gases, and a comprehensive understanding of simultaneously emitted Nr gases from fertilization and their impacts on air quality is still limited.

Injury risk reduction programs including balance training reduce the incidence of anterior cruciate ligament injuries in soccer players: a systematic review and meta-analysis.

Background: Anterior cruciate ligament (ACL) injuries are exceedingly common among soccer players and severely impact their careers and health. This study evaluates the effects of injury risk reduction programs, including balance training exercises, on the incidence of ACL injuries in soccer players through a meta-analysis. The aim is to promote the health of soccer players, enhance their athletic performance, and provide valuable insights for further research in the field of sports medicine.

Relationship between anterior or posterior femoral head necrosis and collapse based on MRI-defined key necrotic layer sets.

Background: Current clinical studies on femoral head necrotic lesions primarily focus on the medial and lateral regions, while detailed MRI-based methods to evaluate the relationship between anterior or posterior necrosis and collapse remain lacking.

Objective: By defining the anterior and posterior positions of the femoral head in MRI, a method was proposed for rapid clinical prognosis assessment of femoral head necrosis based on necrotic location.

Metohd: A retrospective analysis was conducted on TSE sequence T1W1 coronal plane images from 200 cases of femoral head necrosis.

Combined impact of neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and cognitive function on all-cause mortality in older adults: a population-based study.

Background: The neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) has emerged as a potential biomarker for chronic disease outcomes. Cognitive impairment is a major contributor to mortality in older adults. However, the combined effect of NHR and cognitive function on all-cause mortality remains unclear.

The efficacy of exercise prescription in patients with osteoporotic fractures: a systematic review and meta-analysis.

Background: Patients with osteoporotic fractures will further lose bone mineral density and the incidence of refractures will be greatly increased, which is one of the leading causes of death and disability in the elderly. Exercise prescription is effective in enhancing bone strength in patients with osteoporosis, but its effects on patients with osteoporotic fractures have not been systematically reviewed. The purpose of this study is to retrospectively analyze the effect of exercise prescription on bone mineral density in patients with osteoporotic fractures, so as to provide a basis for clinicians to provide postoperative guidance for fracture patients.

Survival analysis of patients with metastatic head and neck squamous cell carcinoma treated with metastasis-directed radiotherapy and immunotherapy.

Objective: Immunotherapy combined with chemotherapy is currently the first-line treatment for metastatic head and neck squamous cell carcinoma (HNSCC). This study aims to evaluate whether adding metastasis-directed radiotherapy (MDRT) to immunotherapy and chemotherapy could improve the survival rate of patients with metastatic HNSCC.

Materials And Methods: A retrospective analysis was conducted on patients with HNSCC who developed distant metastases after curative treatment.