Assessment of Food Effect and pH-Dependent Drug-Drug Interactions of Fruquintinib in Healthy Subjects.

This two-sequence, three-period study (NCT04645940) was designed to evaluate the effect of food and concomitant rabeprazole, a proton pump inhibitor, on the pharmacokinetics (PK) and safety of fruquintinib and its metabolite M11 after a single oral dose of fruquintinib 5 mg in healthy subjects. In the food effect treatment periods, 14 subjects were randomized in a 1:1 ratio utilizing a two-sequence (fed/fasted vs. fasted/fed), two-period, cross-over design.

Smartphone-Manipulated Mild-Temperature Photothermal Control of the TfR-LYTAC Platform for Tumor Treatment.

A lysosome-targeting chimera (LYTAC) offers a novel strategy for degrading extracellular proteins previously considered to be undruggable by hijacking the lysosomal degradation system. However, clinical use of LYTAC has been limited due to the potential for uncontrolled degradation and systemic toxicity. Based on our previously developed genetically encoded TfR-LYTAC, here, we introduce a photothermal-inducible switch in the engineered bacterium to enable spatiotemporal expression of TfR-LYTAC.

A Parameter-Driven Approach to Modulating Chemical Composition in Prussian Blue Analogues Cathodes for Sodium-ion Batteries.

This study explores how various experimental factors, such as temperature, viscosity, and stirring speed, affect Prussian blue analogues (PBAs) material's structural properties and electroneutrality. These factors influence key attributes like sodium ions, vacancies, and water content, which is governed by electroneutrality. Higher temperatures, faster stirring, low viscosity, and high Na+ concentration enhance Na+ incorporation because of the sufficient Na+ supplement, leading to a dense monoclinic structure with fewer vacancies and lower water content.

A Community-Engaged Scoping Review of Affordable Housing Models for LGBTQ+ Older Adults.

Background And Objectives: LGBTQ+ older adults have heightened needs for affordable housing, given structural and systemic barriers and inequities across their lives. Little is known about affordable housing models for LGBTQ+ older adults.

Research Design And Methods: This study presents the first comprehensive review of LGBTQ+ affordable housing to date.

Spray-Dried Inhalable Favipiravir Dry Powder Formulation for Influenza Therapy: Preparation and In vivo Evaluation.

Background: Influenza, a seasonal infectious disease, has consistently posed a formidable challenge to global health in recent years. Favipiravir, an RNA-dependent RNA polymerase inhibitor, serves as an anti-influenza medication, currently administered solely in oral form for clinical use. However, achieving an effective therapeutic outcome often necessitates high oral doses, which can be accompanied by adverse effects and suboptimal patient adherence.

Clinical Evaluation of Spore Oil for Triglyceride Reduction: A Randomized, Double-Blind, Crossover Study.

: spore oil (GLSO) is widely recognized for its notable medicinal and nutritional properties. This study aimed to systematically evaluate the efficacy and safety of GLSO extract in individuals with dyslipidemia. : In a randomized, double-blind, placebo-controlled trial, 110 participants were enrolled and randomly assigned to either the intervention group or the placebo group.

A Cross-Sectional Study of Iodine Nutritional Status Among School-Age Children in Chongqing, China.

: The aim of the present study was to evaluate the iodine nutritional statuses of children aged 8 to 10 years in Chongqing Municipality in 2023. : In this study, we employed multi-stage stratified cluster sampling of non-boarding children aged 8 to 10 years in all 39 counties (districts). The levels of iodine in household salt and those in random urine samples collected from the subjects were tested.

Dietary Guidance, Sensory, Health and Safety Considerations When Choosing Low and No-Calorie Sweeteners.

The growing global focus on the adverse health conditions associated with excessive sugar consumption has prompted health and policy organizations as well as the public to take a more mindful approach to health and wellness. In response, food and beverage companies have proactively innovated and reformulated their product portfolios to incorporate low and no-calorie sweeteners (LNCSs) as viable alternatives to sugar. LNCSs offer an effective and safe approach to delivering sweetness to foods and beverages and reducing calories and sugar intake while contributing to the enjoyment of eating.

Therapeutic Potential of Extract for Hair Health Enhancement: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Hair health critically influences both aesthetic appearance and psychological well-being. Existing treatments often show limited efficacy and may cause side effects. (GP), known for its antioxidant and anti-inflammatory properties, has emerged as a promising botanical agent, although clinical evidence regarding its hair health benefits remains limited.

Tissue-Specific Ablation of Liver Fatty Acid-Binding Protein Induces a Metabolically Healthy Obese Phenotype in Female Mice.

Obesity is associated with numerous metabolic complications including insulin resistance, dyslipidemia, and a reduced capacity for physical activity. Whole-body ablation of liver fatty acid-binding protein (LFABP) in mice was shown to alleviate several of these metabolic complications; high-fat (HF)-fed LFABP knockout (LFABP) mice developed higher fat mass than their wild-type (WT) counterparts but displayed a metabolically healthy obese (MHO) phenotype with normoglycemia, normoinsulinemia, and reduced hepatic steatosis compared with WT. Since LFABP is expressed in both liver and intestine, in the present study, we generated LFABP conditional knockout (cKO) mice to determine the contributions of LFABP specifically within the liver or within the intestine, to the whole-body phenotype of the global knockout.

Dynamics Changes in Physicochemical Properties, Antioxidant Activity, and Non-Volatile Metabolites During Bulang Pickled Tea Fermentation.

The present study investigated the dynamics changes in physicochemical properties and non-volatile metabolites during Bulang pickled tea fermentation. A combination of artificial sensory evaluation, chemical-physical analysis, ultra performance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry (UPLC-QTOF-MS), and multivariate statistical analysis were employed to examine the differences among four fermentation stages of Bulang pickled tea. The bitterness, astringency, sweetness after taste, sourness and fermentation taste tended to increase with fermentation.

Analysis of Potential Markers of Pork Freshness Based on Volatile Organic Compounds.

Bacteria and endogenous enzymes generate volatile organic compounds (VOCs), which are posited to be the primary source of undesirable flavors in spoilt pork. Headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS) was employed to assess the fluctuations in VOC concentrations in pork stored under tray packaging at 6-8 °C for 10 days, while total volatile basic nitrogen (TVB-N) and total viable counts (TVCs) were used to determine the quality of the pork. During storage, TVCs steadily increased, reflecting the growth of spoilage-related microorganisms, while TVB-N levels surpassed the spoilage threshold early, indicating an acceleration of the degradation process.

Characteristic Changes and Potential Markers of Flavour in Raw Pu-Erh Tea with Different Ageing Cycles Analysed by HPLC, HS-SPME-GC-MS, and OAV.

To investigate the flavour evolution mechanism of raw Pu-erh tea (RPT) during storage, the volatile and non-volatile compounds of RPT with different storage years (1-10 years) from the same raw material origin, manufacturer, and storage location in Wenshan Prefecture, Yunnan Province, were systematically analysed by HPLC, HS-SPME-GC-MS, and OAV. The results showed that both cluster analyses based on non-volatile and volatile compounds could classify RPT of different storage years into three ageing cycles, with key turning points in the third and eighth years of storage, which is also accompanied by the colour changing from green to orange or brown, the aroma changing from a faint scent to woody and ageing, the astringency diminishing, and the sweet and mellow increasing. Theophylline was identified as the potential marker of RPT stored 1-3 years, while (-)-catechin gallate, (-)-gallocatechin gallate, quercetin, and rutin as those for a storage of 9-10 years.

Influence of Different Shaping Techniques on the Aroma Quality and Volatile Metabolites of Green Tea Revealed by Gas Chromatography Electronic Nose and Gas Chromatography-Tandem Mass Spectrometry.

The shaping process is recognized as a crucial step in the manufacturing of green tea. However, its influence on aroma quality remains unclear. In this study, the effects of four shaping techniques, including flat green tea (FGT), straight green tea (SGT), phoenix green tea (PGT), and curled green tea (CGT), on the aroma quality and volatile metabolites of green tea were investigated by gas chromatography electronic nose (GC-E-Nose) and gas chromatography-tandem mass spectrometry (GC-MS/MS).

Development of a Magnetic Solid-Phase Extraction-Liquid Chromatography Targeted to Five Fluoroquinolones in Food Based on Aptamer Recognition.

Fluoroquinolones (FQs) are present in trace amounts in the environment, from where they enter animal- and plant-derived food products. Long-term exposure to low-dose drugs poses a risk to human health and increases the pressure on antibiotic selection. Based on previous aptamer screening with high FQs specificity, this study combined a new aptamer recognition probe with a metal-organic framework (MOF) to obtain a sample pretreatment composite material with strong FQs specificity for multi-target analysis.

Effects of Dietary Pretreatment with All- Lycopene on Lipopolysaccharide-Induced Jejunal Inflammation: A Multi-Pathway Phenomenon.

This study was conducted to investigate the effects and mechanisms of all- lycopene on intestinal health by establishing lipopolysaccharide-induced (LPS-induced) jejunal inflammation model. Dietary lycopene supplementation enhanced serum and jejunum antioxidant capacity. Lycopene significantly reduced LPS-induced upregulation of toll-like receptor-4 (TLR-4) and nuclear factor kappa-B (NF-κB), suggesting that lycopene reduced the activation of TLR-4/NF-κB signaling pathway induced by LPS challenge, and further protected mice from LPS induced jejunal inflammation.

Dynamic Changes in Physicochemical Properties and Microbial Diversity During the Fermentation of Mao-Tofu.

Mao-tofu is famous for its unique flavour and texture in Anhui Province, China. The physicochemical properties and microbial diversity of Mao-tofu during different fermentation periods were studied. The pH of the tofu was acidic, the moisture gradually decreased, and the hardness, viscosity, and chewiness gradually increased, while the elasticity gradually decreased.

Analysis of Differences in Volatile Components of Rucheng Baimao () Black Tea in Different Seasons.

At present, there are few studies on seasonal differences in the aroma quality and volatile components of Rucheng Baimao () black tea. In this study, sensory evaluation and volatile component analysis were carried out on one sample of Rucheng Baimao black tea corresponding to spring, summer, and autumn, respectively. The results of sensory evaluation showed that the black teas of all three seasons had floral aromas.

Dynamic Compressive Behavior, Constitutive Modeling, and Complete Failure Criterion of 30 Vol.% BC/2024Al Composite.

This study investigated the compressive behavior of 30 vol.% boron carbide (BC)/2024 aluminum (Al) composites under quasi-static and dynamic loading at different temperatures. Building on the experimental findings, the Johnson-Cook (JC) model was modified, and a complete failure criterion was proposed.

Effect of Quenching Temperature on Microstructure and Hydrogen-Induced Cracking Susceptibility in S355 Steel.

S355 steels are widely used in various applications. However, they may be affected by hydrogen, which can induce hydrogen-induced cracking (HIC). The effects of the quenching temperature () on the microstructure variation and HIC susceptibility of S355 steel was investigated by microstructural characterization, hydrogen permeation (HP) test, slow strain rate tensile (SSRT) test, hydrogen microprint technique (HMT) test, and hydrogen-charged cracking test.

Analysis of the Motion Characteristics of Coarse Aggregate Simulated by Smart Aggregate During the Compaction Process.

Asphalt pavement has become a vital component of modern highway construction due to its high wear resistance, short construction period, economic viability, and excellent skid resistance. However, increasing traffic volume has heightened the structural performance requirements of asphalt pavement, especially during compaction. The compaction degree of asphalt mixtures has emerged as a key indicator for assessing construction quality.

Porous Glass with Layered Morphology Prepared by Phase Separation.

In this study, porous glass with controllable layered structure was successfully prepared by the phase-separation method, with the aim to develop a high-performance high-temperature catalytic (denitrification) material. Glass compositions with different R values (n (NaO)/n (BO)) were designed based on the phase diagram of sodium borosilicate glass. The layered porous structure was obtained by heat treatment in the phase-separation temperature range and acid-leaching treatment to remove the boron-rich phase.

Effect of Annealing Time on Corrosion Behaviours of ZrCuNiAlNb in Hank Solution.

The microstructures of the as-cast and annealed ZrCuNiAlNb were investigated by X-ray diffraction (XRD) and scanning electron microscopy (SEM), their microhardness values were tested, and their corrosion behaviours in Hank solution were studied. XRD results and SEM analysis showed that the as-cast sample was amorphous, and crystallisation occurred in the samples annealed at 923 K for 5-30 min with crystals of ZrCu and ZrNi. Microhardness gradually increased and then levelled off, due to higher crystallisation degree with longer annealing time.

Study on the Robust Bridge Deck Pavement System Based on Horseshoe-Shaped Shear Keys.

Traditional concrete bridge decks often incorporate steel mesh to ensure connection and prevent cracking. However, the cracking in the connecting layer, low bond strength, misalignment of steel mesh, and settling at the bottom often appear. In this study, fiber-reinforced concrete was used for the bridge deck overlay, and a horseshoe-shaped shear key was employed to connect it with the beam body, forming a robust composite bridge deck system.

Preparation of Phosphate Glass by the Conventional and Microwave Melt-Quenching Methods and Research on Its Performance.

In this study, various phosphate glasses (PGs) within the CaO-NaO-PO and SiO-CaO-NaO-PO systems were synthesized using both conventional and microwave melt-quenching techniques. The physical, thermal, and structural properties of these phosphate glasses, as well as their dissolution behaviors under varying temperatures and solvent conditions, were thoroughly examined. Additionally, the influence of scale inhibitor dosage, temperature, and pH on the rate of scale inhibition was assessed using a static scale inhibition test.