Revealing sources for synergistic control of PM, O, and CO in China: Based on social costs of air pollution and climate impact.

China is concurrently facing the dual challenges of air pollution and climate change. Here, we established a coupled modeling framework that integrated a chemical transport model with a health impact assessment model and the human capital method, to quantify the contributions of 150 emission sources (five sectors in 30 provinces) to the CO emissions, and the mortality burdens attributed to O and PM. We found that, in 2019, the estimated premature deaths in China attributed to PM and O pollution were 1,499,073 and 143,420, respectively.

Non-additive effects of leaf-litter flammability on eight subtropical tree species: Implications for forest species composition and fire susceptibility.

The readiness of leaf-litter to burn in the presence of fire differs greatly between species. Thus, forests composed of different species vary in their susceptibility to fire. Fire susceptibility of forests may also differ from the arithmetic means of flammability of their component species, i.

Effects of pristine and photoaged tire wear particles and their leachable additives on key nitrogen removal processes and nitrous oxide accumulation in estuarine sediments.

Despite growing attention to the environmental pollution caused by tire wear particles (TWPs), the effects of pristine and photoaged TWPs (P-TWPs and A-TWPs) and their TWP leachates (TWPLs; P-TWPL and A-TWPL) on key nitrogen removal processes in estuarine sediments remain unclear. This study explores the responses of the denitrification rate, anammox rate, and nitrous oxide (NO) accumulation to P-TWP, A-TWP, P-TWPL, and A-TWPL exposure in estuarine sediments, and assesses the potential biotoxic substances present in TWPLs. P-TWPs reduced the denitrification rate by 17.

Distinguishing the botanical origins of rare honey through untargeted metabolomics and machine learning interpreting flavonoid profiles.

Distinguishing the botanic origins of monofloral honey is the foremost concern in ensuring its authentication. In this work, an innovative, green, and comprehensive approach was developed to distinguish the botanic origins of four types of rare honey, and the strategy involved in the following aspects: Based on theoretical design, suitable natural deep eutectic solvent (NADES) was screened to extract flavonoids from honey samples; after NADES extracts were directly analyzed by high-resolution mass spectrometry, the discrimination models of monofloral honey were established by untargeted metabolomics combined with machine learning. Based on the comparison of various models, the Random Forest algorithm had higher prediction accuracy for four types of monofloral honey, and characteristic compounds for each rare monofloral honey were screened based on SHapley Additive exPlanations values.

Variation of biogenic VOC contribution to ozone formation with reduced anthropogenic precursor emissions: Coupling online observation and future scenario simulation.

As an essential component of urban natural sources, isoprene has strong interactions and synergies with anthropogenic precursors (volatile organic compounds and nitrogen oxides) of ozone (O), influencing O formation in urban areas. However, the variability of these effects under different anthropogenic emission scenarios has not been fully understood. This study, utilizing observational data from Dezhou (a medium-sized city in the center of North China Plain) from May to September in both 2019 and 2020, and incorporating four future scenarios based on Shared Socioeconomic Pathways (SSP1-2.

Mechanism-guided engineering of a minimal biological particle for genome editing.

The widespread application of genome editing to treat and cure disease requires the delivery of genome editors into the nucleus of target cells. Enveloped delivery vehicles (EDVs) are engineered virally derived particles capable of packaging and delivering CRISPR-Cas9 ribonucleoproteins (RNPs). However, the presence of lentiviral genome encapsulation and replication proteins in EDVs has obscured the underlying delivery mechanism and precluded particle optimization.

Identification of biomarkers associated with ferroptosis in macrophages infected with Mycobacterium abscessus using bioinformatic tools.

Mycobacterium abscessus is a rapidly growing nontuberculous mycobacterium that causes severe pulmonary infections. Recent studies indicate that ferroptosis may play a critical role in the pathogenesis of M. abscessus pulmonary disease.

Using a visual attentional task and eye-tracking to investigate the effects of pre-takeover resource engagement on attention restoration in conditionally automated driving.

Objective: Attention forms the foundation for the formation of situation awareness. Low situation awareness can lead to driving performance decline, which can be dangerous in driving. The goal of this study is to investigate how different types of pre-takeover tasks, involving cognitive, visual and physical resources engagement, as well as individual attentional function, affect driver's attention restoration in conditionally automated driving.

Covalent Grafting of Graphene Quantum Dots onto Stepped TiO-Mediated Electronic Modulation for Electrocatalytic Hydrogen Evolution.

The interaction between electrocatalytic active centers and their support is essential to the electrocatalytic performance, which could regulate the electronic structure of the metal centers but requires precise design. Herein, we report on covalent grafting of graphene quantum dots (GQDs) on stepped TiO as a support to anchoring cobalt phosphide nanoparticles (CoP/GQD/S-TiO) for electrocatalytic hydrogen evolution reaction (HER). The covalent ester bonds between GQDs and TiO endow enlarged anchoring sites to achieve highly dispersed electroactive CoP nanoparticles but, more importantly, provide an efficient electron-transfer pathway from TiO to GQDs which could regulate the electronic structure of CoP.

Successful treatment of epidermal growth factor receptor exon 19 deletion non-small cell lung cancer with almonertinib after osimertinib-induced interstitial lung disease: A case report.

Osimertinib, a third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), has revolutionized one of the standard most efficient treatments for EGFR mutation-positive non-small cell lung cancer (NSCLC). Osimertinib, a third-generation EGFR-TKI, is currently one of most efficient treatments in clinical practice. However, it has a potentially fatal side effect: interstitial lung disease (ILD).

Chemodivergent and Enantioselective Synthesis of Spirobi[dihydrophenalene] Structures.

The development and enantioselective synthesis of two types of -symmetric spirobi[dihydrophenalene] structures is reported. The reaction proceeds via rhodium-catalyzed 2-fold asymmetric conjugate arylation of dienones followed by BF·OEt-promoted spirocyclization to give the enantiopure spiro products. Additive-dependent chemodivergent synthesis of 3,3'-diarylated 2,2',3,3'-tetrahydro-1,1'-spirobi[phenalene]-9,9'-diols (3,3'-Ar-SPHENOLs) and the corresponding spiro diary ethers from the same intermediate is achieved.

Exploration and computational assessment of ochrocephalamine G from as an anti-HBV candidate.

Three compounds, including a novel quinolizidine alkaloid, ochrocephalamine G (), were isolated from . Structural elucidation was achieved through spectroscopic analysis and electronic circular dichroism. Biological assays showed that ochrocephalamine G (100 μM) inhibited HBsAg and HBeAg by 8.

Nonlinear Optics in Two-Dimensional Magnetic Materials: Advancements and Opportunities.

Nonlinear optics, a critical branch of modern optics, presents unique potential in the study of two-dimensional (2D) magnetic materials. These materials, characterized by their ultra-thin geometry, long-range magnetic order, and diverse electronic properties, serve as an exceptional platform for exploring nonlinear optical effects. Under strong light fields, 2D magnetic materials exhibit significant nonlinear optical responses, enabling advancements in novel optoelectronic devices.

The Effect of Molten Salt Composition on Carbon Structure: Preparation of High Value-Added Nano-Carbon Materials by Electrolysis of Carbon Dioxide.

The electrochemical conversion of CO into high value-added carbon materials by molten salt electrolysis offers a promising solution for reducing carbon dioxide emissions. This study focuses on investigating the influence of molten salt composition on the structure of CO direct electroreduction carbon products in chloride molten salt systems. Using CaO as a CO absorber, the adsorption principle of CO in LiCl-CaCl, LiCl-CaCl-NaCl and LiCl-CaCl-KCl molten salts was discussed, and the reasons for the different morphologies and structures of carbon products were analyzed, and it was found that the electrolytic efficiency of the whole process exceeded 85%.

Nanosized κ-Carbide and B2 Boosting Strength Without Sacrificing Ductility in a Low-Density Fe-32Mn-11Al Steel.

High-performance lightweight materials are urgently needed because of energy savings and emission reduction. Here, we design a new steel with a low density of 6.41 g/cm, which is a 20% weight reduction compared to the conventional steel.

Review: Animal-assisted intervention for children with attention-deficit/hyperactivity disorder - a systematic review and meta-analysis.

Background: Animal-assisted interventions (AAIs) have emerged as a promising nonpharmacological intervention option for children diagnosed with attention-deficit/hyperactivity disorder (ADHD). However, recent systematic reviews have been primarily narrative. Additionally, the pooled effectiveness of AAIs was absent from these systematic reviews.

Ancient DNA elucidates the migration and evolutionary history of northern and southern populations in East Asia.

Over the past decade, the continuous development of ancient genomic technology and research has significantly advanced our understanding of human history. Since 2017, large-scale studies of ancient human genomes in East Asia, particularly in China, have emerged, resulting in a wealth of ancient genomic data from various time periods and locations, which has provided new insights into the genetic history of East Asian populations over tens of thousands of years. Especially since 2022, there emerged a series of new research progresses in the genetic histories of the northern and southern Chinese populations within the past 10,000 years.

Functional response of two Mesocomys species on factitious host Antheraea pernyi and their biocontrol potential against the Japanese giant silkworm Caligula japonica.

Background: The Japanese giant silkworm (JGS) Caligula japonica is a significant defoliator pest in East Asia, causing severe economic losses in forest and fruit production. To establish a cost-effective biological control program against JGS, the age-stage, two-sex life table method was used to accurately assess the potential efficacy of two Mesocomys species (M. albitarsis and M.

Discovery, Characterization, and Anti-XOD Activity of Calcium Metallophore from .

In this work, coixalkyne A (), a natural polynuclear calcium complex with a novel cross-shaped molecular architecture, was isolated from L. along with the undescribed analogue coixalkyne B (). Their structures were identified by means of NMR spectroscopy, ECD calculations, and single-crystal X-ray diffraction.

Neural structural alterations correlates of quadriceps muscle strength deficits in patients after anterior cruciate ligament reconstruction.

Background: Persistent maladaptive changes of corticospinal tract (CST) and quadriceps strength deficits exist in patients with anterior cruciate ligament reconstruction (ACLR). This study aimed to investigate the relationships between the structural alterations of CST and quadriceps muscle strength deficits in patients with ACLR.

Methods: Twenty-nine participants who had undergone unilateral ACLR (29 males; age = 32.

Assessing the impact of evolocumab on thin-cap fibroatheroma and endothelial function in patients with very high-risk atherosclerotic cardiovascular disease: a study protocol for a randomized controlled trial.

Background: The prevalence of very high-risk atherosclerotic cardiovascular disease (ASCVD) is significant in China, with suboptimal rates of low-density lipoprotein cholesterol (LDL-C) compliance exacerbating plaque instability and causing a higher incidence of major adverse cardiac events (MACEs). Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are effective in reducing LDL-C levels, increase the stability of vulnerable plaque, and influence the progression of atherosclerosis through multiple mechanisms as demonstrated in animal studies. However, there is currently a lack of evidence regarding the efficacy and safety of high-intensity statin therapy combined with PCSK9i in the secondary prevention of ASCVD in the Chinese population.

Biomimetic Diselenide-Sonosensitizer Nanoplatform for Enhanced Sonodynamic Therapy and In Situ Remodeling Immunosuppressive Microenvironment via Activating Innate and Adaptive Immunotherapy.

Sonodynamic therapy (SDT), which is non-invasive and controllable has the potential to treat triple-negative breast cancer (TNBC). However, the hypoxia and immunosuppressive tumor microenvironment (TME) often block the production of reactive oxygen species and the induction of SDT-activated immunogenic cell death, thus limiting the activation of adaptive immune responses. To alleviate these challenges, we proposed the development of a multifunctional biomimetic nanoplatform (mTSeIR), which was designed with diselenide-conjugated sonosensitizers and tirapazamine (TPZ), encapsulated within M1 macrophage membrane.

Pressure regulated CO electrolysis on two-dimensional BiOSe.

The electrochemical reduction of carbon dioxide (CORR) offers potential for sustainable production and greenhouse gas mitigation, particularly with renewable energy integration. However, its widespread application is hindered by expensive catalysts, low selectivity, and limited current density. This study addresses these challenges by developing a low-mass-loading two-dimensional (2D) BiOSe catalyst chemical vapor deposition (CVD).

Visible-light-mediated selenocyclization of -vinylanilides with diselenides.

Herein, we describe a visible-light-mediated selenocyclization of -vinylanilides with diselenides, which provides a mild and effective method for the synthesis of selenylated 4-3,1-benzoxazines. This reaction proceeds under metal-free conditions, without the need for a chemical oxidant or a controlled O atmosphere and shows a broad substrate scope with yields of up to 98%. Additionally, the process is easily scalable to the gram scale.

Classifying and Characterising Unmet Integrated Care Needs of Older Adults With Multimorbidity: A Latent Profile Analysis.

Aims: To classify the unmet integrated care needs of older adults with multimorbidity and to explore the factors associated with different categories of unmet integrated care needs among the target population.

Design: A cross-sectional survey using the statistical method of latent profile analysis.

Methods: From July 2022 to March 2023, 397 older adults with multimorbidity, aged 60 years or older, were recruited from one primary healthcare setting and from four secondary and tertiary hospitals to participate in face-to-face questionnaire surveys.