Gestational exposure to ambient fine particulate matter disrupts maternal hepatic lipid metabolism.

Pregnancy is a unique physiological stage for females as well as a vulnerable period for pollutant exposure. The effect of gestational ambient fine particulate matter (PM) exposure on maternal lipid metabolism during pregnancy is rarely observed, and the mechanism is unknown. In the current study, pregnant C57BL/6 mice were randomly assigned to either ambient PM or filtered air exposure chambers since gestational day (GD) 0.

Lipidomics and transcriptomics insight into impacts of microplastics exposure on hepatic lipid metabolism in mice.

Microplastics (MPs), the emerging environmental pollutants, have attracted global attention due to the potential public health challenge and ecological security risk. Recent studies suggested liver as a vulnerable organ to MPs exposure, evidenced by abnormal hepatic lipid metabolism upon MPs intake in multiple animal species. However, the specific changes of lipid metabolism in mammalian livers, as well as the underlying mechanisms, remain to be elucidated.

Sex difference in effects of intermittent heat exposure on hepatic lipid and glucose metabolisms.

Global climate warming has drawn worldwide attention. However, the health impact of heat exposure is still controversial. This study aimed to explore the exact effects and sex differential vulnerability under intermittent heat exposure (IHE) patterns and tried to elucidate the potential mechanisms by which IHE modulated hepatic lipid and glucose homeostasis.

Ambient fine particulate matter exposure disrupts placental autophagy and fetal development in gestational mice.

Recent studies have shown that some adverse pregnancy outcomes, especially intrauterine growth restriction (IUGR), are associated with gestational exposure to ambient fine particulate matter (PM). However, potential mechanism remains to be elucidated. In the present study, pregnant C57BL/6 mice were randomly assigned to be exposed to either filtered air or ambient PM in the gestation period via a concentrated whole-body exposure system.

Effect of GEN1 interference on the chemosensitivity of the breast cancer MCF-7 and SKBR3 cell lines.

Chemotherapy is a notable method for the treatment of breast cancer. Numerous genes associated with the sensitivity of cancer to chemotherapy have been found. In recent years, evidence has suggested that a particular structure termed Holliday junction (HJ) plays a crucial role in cancer chemosensitivity.

Inhibition of Mus81 by siRNA enhances sensitivity to 5-FU in breast carcinoma cell lines.

Purpose: One of the most challenging aspects of breast carcinoma chemotherapy is the rapid acquirement of drug resistance. Improving the sensitivity to chemotherapeutic drugs is very important for successful treatment. Mus81 plays an important role in maintaining the stability of the genome and DNA repair.

A comparison of biochars from lignin, cellulose and wood as the sorbent to an aromatic pollutant.

Biochars' performance as the sorbent to pollutants is dependent on their compositions and surface characteristics, which are then related to the feedstock used for biochar preparation. The objective of this work is to probe the feedstock's influence on biochar's sorption property through a comparative study on biochars from lignin, cellulose and wood prepared at 400°C and 600°C, respectively. Elemental and spectral analyses demonstrated that the wood biochar had a composition and carbonization degree close to the cellulose biochar but much different from the lignin biochar prepared at the same temperature, suggesting that lignin is not dominant to properties of plant-derived biochars.