D-ribose-5-phosphate inactivates YAP and functions as a metabolic checkpoint.

Background: Targeting glucose uptake by glucose transporter (GLUT) inhibitors is a therapeutic opportunity, but efforts on GLUT inhibitors have not been successful in the clinic and the underlying mechanism remains unclear. We aim to identify the key metabolic changes responsible for cancer cell survival from glucose limitation and elucidate its mechanism.

Methods: The level of phosphorylated YAP was analyzed with Western blotting and Phos-tag immunoblotting.

A review of deep learning models for the prediction of chromatin interactions with DNA and epigenomic profiles.

Advances in three-dimensional (3D) genomics have revealed the spatial characteristics of chromatin interactions in gene expression regulation, which is crucial for understanding molecular mechanisms in biological processes. High-throughput technologies like ChIA-PET, Hi-C, and their derivatives methods have greatly enhanced our knowledge of 3D chromatin architecture. However, the chromatin interaction mechanisms remain largely unexplored.

A multi-memory-augmented network with a curvy metric method for video anomaly detection.

Anomaly detection task in video mainly refers to identifying anomalous events that do not conform to the learned normal patterns in the inferring phase. However, the Euclidean metric used in the learning and inferring phase by the most of the existing methods, which cannot measure the difference between the different high-dimensional data reasonably, because the Euclidean distance between the different high-dimensional data will gradually become the same as the dimension increases. In this paper, we propose a Multi-Memory-Augmented dual-flow network with a new curvy metric method, to remove this shortcoming of Euclidean metric.

Exploring bio-remediation strategies by a novel bacteria Micrococcus sp. strain HX in Cr(VI)-contaminated groundwater from long-term industrial polluted.

Hexavalent chromium (Cr(VI)) has emerged as a contaminant of heavy metal, owing to its wide use in industry. This study focuses on elucidating the interaction between microbial communities and environmental parameters in Cr(VI)-contaminated groundwater near a factory in Henan Province, and evaluating the bio-remediation potential of microorganisms toward Cr(VI) reduction. The highest concentration of Cr(VI) in the groundwater is 208.

A flexible and energy independent fluorescence radiation fiber film dosimeter fabricated by electrostatic spinning.

Doping fluorescent substances in polymer matrices has shown promising applications in radiation dose sensing. In this work, quinoline dye based polyvinyl chloride fibrous films with fiber diameters of 123 nm, 540 nm and 864 nm were obtained by electrostatic spinning. The introduction of the fiber film structure makes the fluorescent film dosimeter flexible and lightweight compared to normal solid fluorescent films and further extends the linear range of X-ray detection to 0-350 Gy.

[A fluorescence immunochromatography method for detection of human papillomavirus type 16 E6 and L1 proteins].

This study aims to establish a time-resolved fluorescence immunochromatography method for simultaneous determination of human papillomavirus (HPV) type 16 E6 and L1 protein concentrations. The amount of lanthanide microsphere-labeled antibodies, the concentration of coated antibodies, and the reaction time were optimized, and then a test strip for the simultaneous determination of the protein concentrations was prepared. The performance of the detection method was evaluated based on the concordance of the results from clinical practice.

Witnessing Quantum Incompatibility Structures in High-Dimensional Multimeasurement Systems.

Quantum incompatibility, referred as the phenomenon that some quantum measurements cannot be performed simultaneously, is necessary for various quantum information processing tasks, such as nonlocality and steering. When these applications come to high-dimensional multimeasurement scenarios, it is crucial and challenging to witness the incompatibility of measurements with complex structures. To address this problem, we propose a modified quantum state discrimination protocol that decomposes complex compatibility structures into pairwise ones and employs noise robustness to bound incompatibility structures.

A high-resolution 3D radiochromic hydrogel photonic crystal dosimeter for clinical radiotherapy.

The precise, rapid and direct visualization of 3D topographical dose in the target tissue that is crucial for effective radiation therapy remains a challenge. Herein, by combining hydrogel photonic crystals with film stacking or 3D printing, a 3D radiochromic dosimeter with a dose sensitivity of up to 10 nm Gy, a spatial resolution <50 μm, and the ability to detect complex 3D topographical dose distribution was proposed for clinical radiation dose verification. The sensitivity and response range of the dosimeter by radiation-induced polymer cross-linking and consequent Bragg wavelength shift can be tuned the solid content and extent of acrylate modification.

Mediterranean diet and atrial fibrillation: a case-control study from China.

Objective: The aim of this study was to assess the association between adherence to Mediterranean diet and the presence of atrial fibrillation (AF) in a Northern Chinese population.

Methods: This study was a single center, case-control study. A total of 952 low risk participants in Beijing Anzhen Hospital from 2016 to 2021 were collected, including 476 patients with first diagnosed of atrial fibrillation and 476 age and sex matched controls.

Association of oral health with nutritional status of the older adults: a cross-sectional study.

Objectives: The potential association between oral health and nutritional status of the very old, has been poorly investigated. Thus, we carried out the cross-sectional study to evaluate the association of oral health with the nutritional status of the older adults.

Methods: 210 participants aged over 75 years were included in the study.

Steering-Angle Prediction and Controller Design Based on Improved YOLOv5 for Steering-by-Wire System.

A crucial role is played by steering-angle prediction in the control of autonomous vehicles (AVs). It mainly includes the prediction and control of the steering angle. However, the prediction accuracy and calculation efficiency of traditional YOLOv5 are limited.