Palmitic acid-induced microRNA-143-5p expression promotes the epithelial-mesenchymal transition of retinal pigment epithelium via negatively regulating JDP2.

Background: The epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is the most crucial step in the etiopathogenesis of proliferative vitreoretinopathy. This study aimed to investigate the role of miR-143-5p in the EMT of RPE cells induced by palmitic acid (PA).

Methods: ARPE-19 cells were treated with PA to induce EMT, followed by E-cadherin and α-smooth muscle actin (α-SMA) expression and the microRNA expression profile analyses.

Sulfiredoxin-1 protects retinal ganglion cells from high glucose-induced oxidative stress and inflammatory injury by potentiating Nrf2 signaling via the Akt/GSK-3β pathway.

Sulfiredoxin-1 (Srxn1) has been acknowledged as a remarkable pro-survival factor in the protection of cells against stress-induced damage. The persistent exposure of retinal ganglion cells (RGCs) to high glucose (HG) in diabetes induces cellular damage, which contributes to the onset of diabetic retinopathy, a severe complication of diabetes. So far, little is known about the role of Srxn1 in regulating HG-induced injury of RGCs.

Adaptive Resilient Event-Triggered Control Design of Autonomous Vehicles With an Iterative Single Critic Learning Framework.

This article investigates the adaptive resilient event-triggered control for rear-wheel-drive autonomous (RWDA) vehicles based on an iterative single critic learning framework, which can effectively balance the frequency/changes in adjusting the vehicle's control during the running process. According to the kinematic equation of RWDA vehicles and the desired trajectory, the tracking error system during the autonomous driving process is first built, where the denial-of-service (DoS) attacking signals are injected into the networked communication and transmission. Combining the event-triggered sampling mechanism and iterative single critic learning framework, a new event-triggered condition is developed for the adaptive resilient control algorithm, and the novel utility function design is considered for driving the autonomous vehicle, where the control input can be guaranteed into an applicable saturated bound.

Higher serum level of myoglobin could predict more severity and poor outcome for patients with sepsis.

Background: There have been sporadic case reports published focusing on myoglobin and sepsis. However, there are no systematic studies evaluating the correlation between myoglobin level and sepsis. This study investigated the correlation between the serum myoglobin level and the severity of septic patients.

Clinical evaluation of circulating microRNA-25 level change in sepsis and its potential relationship with oxidative stress.

Objective: To investigated the circulating microRNA expression profile in sepsis and its clinical evaluation.

Methods: 70 patients with sepsis and 30 patients with SIRS were selected and their blood samples were collected. Using liquid bead array with 3 statistical analysis approaches analyzed the circulating microRNA expression profiles, for confirming the data of liquid bead array, qRT-PCR was performed.