Microplastics exposure disrupts nephrogenesis and induces renal toxicity in human iPSC-derived kidney organoids.

Microplastics (MPs) have emerged as a pervasive environmental pollutant of global concern. Their detection within the human placenta and fetal organs has prompted apprehension regarding the potential hazards of MPs during early organogenesis. The kidney, a vital multifunctional organ, is susceptible to damage from MPs in adulthood.

Development of an alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell-derived liver organoids.

Alcoholic liver disease (ALD) poses a significant health challenge, so comprehensive research efforts to improve our understanding and treatment strategies are needed. However, the development of effective treatments is hindered by the limitation of existing liver disease models. Liver organoids, characterized by their cellular complexity and three-dimensional (3D) tissue structure closely resembling the human liver, hold promise as ideal models for liver disease research.

Decentralized Dynamic Event-Triggered Output Feedback Adaptive Fixed-Time Funnel Control for Interconnection Nonlinear systems.

A decentralized dynamic event-triggered output feedback adaptive fixed-time (DDETOFAFxT) funnel controller is described for a class of interconnected nonlinear systems (INSs). A novel dynamic event-triggered mechanism is designed, which includes a triggering control input, fixed threshold, decreasing function of tracking error, and a dynamic variable. To obtain the unknown states, a decentralized linear filter is designed.

H control for time-delay systems with randomly occurring nonlinearities subject to sensor saturations, missing measurements and channel fadings.

The H control problem for a class of time-delay systems with randomly occurring nonlinearities (RONs) is addressed in this paper. Sensor saturations, missing measurements and channel fadings are governed by random variables obeying the Bernoulli distributions. The measurement output is subject to both data missing and randomly occurring sensor saturations (ROSSs) described by sector-nonlinearities as well as the channel fadings caused typically in wireless communication.

X indening oral liquid improves cardiac function of rats with chronic cardiac failure via TGF-ß1/Smad3 and p38 MAPK pathway.

Objective: Xindening oral liquid (Xin) is a widely used traditional Chinese medicine for the treatment of chronic heart failure (CHF). However, the exact mechanisms related to its therapeutic effects against CHF remain unclear. In the present study, we investigate the effects of Xin on cardiac function in CHF rats and the possible mechanisms involved.

Molecular cloning of Brassica napus TRANSPARENT TESTA 2 gene family encoding potential MYB regulatory proteins of proanthocyanidin biosynthesis.

Three members of Brassica napus TRANSPARENT TESTA 2 (BnTT2) gene family encoding potential R2R3-MYB regulatory proteins of proanthocyanidin biosynthesis were isolated. BnTT2-1, BnTT2-2, and BnTT2-3 are 1102 bp with two introns, and have a 938-bp full-length cDNA with a 260 amino acid open reading frame. They share 98.