Publications by authors named "Yunliang Shen"

Utilizing an automated optimization method, we propose a perfectly vertical grating coupler (PVGC) characterized by random structure, superior performance, simplified fabrication process, and increased minimum feature size (MFS). Within the range of MFS from 60 to 180 nm, the optimized PVGC exhibited a simulated coupling efficiency of approximately -2.0 dB at 1550 nm with a 34 nm 1-dB bandwidth.

View Article and Find Full Text PDF

Context: Gonorrhea, a highly communicable, sexually transmitted infection, remains a major public-health concern globally. In recent years, Zhejiang province, an eastern province, has had the highest incidence of gonorrhea in China.

Objective: The study intended to identify the geographic distribution patterns and spaciotemporal clustering characteristics of the disease's incidence in Zhejiang between 2016 and 2020, to understand the spatial epidemiology of gonorrhea and to pinpoint the locations with relatively high risks of gonorrhea, the hotspots, which could be the key areas for disease prevention and control.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates antimicrobial resistance (AMR) in Mycobacterium causing leprosy in Zhejiang Province, China, focusing on new cases from 2018 to 2021.
  • Out of 34 leprosy cases, 5.9% showed drug resistance mutations to dapsone and ofloxacin, with no significant associations found between resistance and various patient demographics.
  • The findings indicate good control of leprosy in the region, but further research is needed on the implications of identified gene mutations, as the low prevalence makes comprehensive analysis challenging.
View Article and Find Full Text PDF

Background: Leprosy is a chronic infectious disease that causes disabilities and deformities. Early detection is a major strategy for leprosy control. This study reported a new practice of suspicious symptom monitoring for early detection of leprosy.

View Article and Find Full Text PDF
Article Synopsis
  • HIV self-testing (HIVST) can enhance the frequency of HIV testing among men who have sex with men (MSM), which is vital for reducing HIV transmission risk.
  • A study in Ningbo, China found that 38.2% of MSM had used HIVST, with users showing a significantly higher frequency of HIV testing compared to non-users.
  • Factors influencing HIVST uptake included being younger, having a higher education level, using gay apps, having multiple male partners, frequent sexual contact, and a history of syphilis infection.
View Article and Find Full Text PDF

Background: After the elimination of leprosy in 1995, there were 10-30 newly detected leprosy cases every year in Zhejiang Province, and the epidemiological characteristics of the newly detected leprosy cases have changed. While most of the newly detected cases came from other provinces in China, not Zhejiang, it brought a new challenge for leprosy prevention and control in post- elimination era in Zhejiang, China. This study was aimed to understand the temporal-spatial distribution characteristics of newly detected leprosy cases, and provide the scientific rationales for the development of leprosy control strategy.

View Article and Find Full Text PDF

Purpose: Genome-wide association studies (GWAS) have identified multiple genetic variants associated with leprosy. To investigate the single and combined associations between single-nucleotide polymorphisms (SNPs) and the development of leprosy, we therefore performed generalized multi-analytical (GMDR) analysis in Chinese leprosy household contacts and constructed a risk prediction model.

Patients And Methods: This case-control study included 229 leprosy cases and 233 healthy household contacts in Zhejiang province, China.

View Article and Find Full Text PDF

Importance: Dapsone hypersensitivity syndrome (DHS) is the most serious adverse reaction associated with dapsone administration and one of the major causes of death in patients with leprosy, whose standard treatment includes multidrug therapy (MDT) with dapsone, rifampicin, and clofazimine. Although the HLA-B*13:01 polymorphism has been identified as the genetic determinant of DHS in the Chinese population, no studies to date have been done to evaluate whether prospective HLA-B*13:01 screening could prevent DHS by identifying patients who should not receive dapsone.

Objective: To evaluate the clinical use of prospective HLA-B*13:01 screening for reduction of the incidence of DHS by excluding dapsone from the treatment for patients with HLA-B*13:01-positive leprosy.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionn76qk7hnkkn54fpbc0noqt0qfbp49jvn): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once